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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 3 | 巨噬细胞、细胞因子和脓毒症显示文摘巨噬细胞激活以及巨噬细胞因子白介素1(IL-1)、白介素6(IL-6)和肿瘤坏死因子(TNF)分泌的增加与脓毒症的发生发展有着密切的联系。采用这些细胞因子的桔抗物(如TNF单抗、消炎痛等)以及用小剂量内毒素诱导内毒素耐受性均能降低巨噬细胞因子分泌反应并提高脓毒症动物的生存率。本文对有关进展作综合介绍。 | Walsh CJ León P O'Riordain MG Ayala A 密磊 | 1993 | 国外医学(创伤与外科基本问题分册)1993，14，1： | 3 |
| 4 | Comparison of Digital Subtraction Angiography with Gadolinium-Enhanced Magnetic Resonance Angiography in the Diagnosis of Renal Artery Stenosis显示文摘 | Thornton J O'Callaghan J Walshe J | 1999 | Eur Radiol1999，9，5： | 1 |
| 5 | Augmented Hopfield Network for Unit Commitment and Economic Dispatch显示文摘 | Walsh M P O'Malley M J | 1997 | IEEE Trans on Power Systems1997，12，4： | 1 |
| 6 | Asymptotic Behavior of Nonlinear Networked Control Systems显示文摘 | Walsh G C Beldiman O Bushnell L G | 2001 | IEEE Transactions on Automatic Control (S0018-9286)2001，46，7： | 1 |
| 7 | The insulin-like growth factor- Ⅰ receptor is regulated by CD28 and protects activated Tcells from apoptosis 显示文摘 | Walsh PT O'Connor R | 2000 | Eur J Immunol2000，30，4： | 1 |
| 8 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 9 | Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism显示文摘 | Criona M Walshe John G Laffey Leo Kevin Daniel O’Toole | 2015 | Intensive Care Medicine Experimental2015，，1： | 1 |
| 10 | Resection of sternal tumors:extent,reconstruction,and survival显示文摘 | Soysal O Walsh CL Nesbitt JC | 1995 | Ann Thorac Surg1995，60，： | 1 |
| 11 | Asymptotic Behavior of Nonlinear Networked Control Systems显示文摘 | Walsh G C Beldiman O Bushnell L G | 2001 | IEEE Trans on Automatic Control2001，46，7： | 1 |
| 12 | The Synergraft valve:A new acellular(nonglutaraldehyde-fixed) tissue heart valve for autologous recellularization first experimental studies before clinical implantation显示文摘 | Goldstein S Walsh S | 1999 | Semin Thora Cardiovasc Surg1999，111，41： | 1 |
| 13 | Transcranial magnetic stimulation显示文摘 | O'Shea J Walsh V | | 0，，6： | 1 |
| 14 | Mutations in an auxin receptor homolog AFB5 and in SGT1bconfer resistance to synthetic picolinate auxins and not to 2,4-D or IAA in Arabidopsis显示文摘 | WALSH T A NEAL R MERLO A O HONMA M HICKS G R WOLFF K MATSUMURA W DAVIES J P | 2006 | Plant Physiology2006，142，： | 1 |
| 15 | Sensory comparison of commercial low and high oxygen modified atmosphere packed sirloin beef steaks 显示文摘 | IAKRYS-WALIWANDER P I O'SUHIVAN M G H WALSH | 2011 | Meat Science2011，88，1： | 1 |
| 16 | The views of patients with severe chronic obstructive pulmonary disease on advance care planning:A qualitative study显示文摘 | MacPherson A Walshe C O'Donnell V | | 0，，3： | 1 |
| 17 | The SynerGraft valve: a new acellular (nonglutaraldehyde-fixed) tissue heart valve for autologous recellularization:first experimental studies before clinical implantation显示文摘 | Goldstein S Walsh S | 1999 | Semin Thorac Cardiovasc Surg1999，11，41： | 1 |
| 18 | Resection of sternal tumors: extent, reconstruction, and survival 显示文摘 | Soysal O Walsh GL Nesbitt JC | 1995 | Ann Thorac Surg1995，60，5： | 1 |
| 19 | Multi-channel surface NMR instrumentation and software for 1D/2D groundwater investigations显示文摘 | Walsh D O | 2008 | Journal of Applied Geophysics:2008，66，： | 1 |
| 20 | Evaluation of cholesterol additions to soybean meal-based diet for juvenile Pacific white shrimp, Penaeus vannamei(Boone) , in an outdoor growth trial显示文摘 | Duerr E O Walsh W A | 1996 | Aquaculture nutrition1996，2，： | 1 |
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