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| 1 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 2 | A Pooled Analysis of Advanced Colorectal Neoplasia Diagnoses After Colonoscopic Polypectomy显示文摘 | María Elena Martínez John A. Baron David A. Lieberman Arthur Schatzkin Elaine Lanza Sidney J. Winawer Ann G. Zauber Ruiyun Jiang Dennis J. Ahnen John H. Bond Timothy R. Church Douglas J. Robertson Stephanie A. Smith–Warner Elizabeth T. Jacobs David S. Alb | 2009 | Gastroenterology2009，，3： | 2 |
| 3 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 4 | Identification of novel Smad binding proteins 显示文摘 | Warner D R Roberts E A Greene R M | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 5 | Targeting Axl and Mer Kinases in Cancer显示文摘 | Verma A Warner SL Vankayalapati H | 2011 | Mol Cancer Ther2011，10，10： | 1 |
| 6 | Upward lightning observa- tions from towers in Rapid City, South Dakota and comparison with National Lightning Detection Network data, 2004-2010显示文摘 | Warner T A Cummins K L Orville R E | 2012 | Journal of Geophysical Research: Atmospheres2012，117，19： | 1 |
| 7 | Structure and flexibility of the complete periplasmic domain of BamA:the protein insertion machine of the outer membrane显示文摘 | Gatzeva-Topalova PZ Warner LR Pardi A Sousa MC | | 0，，11： | 1 |
| 8 | Partners in crime:the TGFβ and MAPK pathways in cancer progression显示文摘 | Douglas A Chapnick Lisa Warner Jennifer Bemet | | 0，，： | 1 |
| 9 | The c-myc x E2F-1/p21 interactive gene expression index augments cytomorphologic diagnosis of lung cancer in fine-needle aspirate specimens显示文摘 | Crawford EL Zaher A | 2003 | J Mol Diagn2003，5，3： | 1 |
| 10 | Male and female alternative reproductive behaviors in fishes: a new approach using intersexual dynamies显示文摘 | HENSON S A WARNER R R | 1997 | Annual Review of Ecology and Systematics1997，28，： | 1 |
| 11 | Ecology of testate amoebae (Protozoa: Rhizopoda) in Sphagnum peatlands in the Jura mountains, Switzerland and France显示文摘 | Mitchell E A D Buttler A J Warner B G | 1999 | Ecoscicnce1999，6，： | 1 |
| 12 | Lifetime cooecurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the national comorbidity survey 显示文摘 | Kessler R C Crum R M Warner L A | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 13 | Parametric investigation of load-induced structure remodeling in the proximal femur显示文摘 | Marzban A Canavan P Warner G | 2012 | Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine2012，226，6： | 1 |
| 14 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 15 | The Shc-related adaptor protein, Sck, forms a complex with the vascularendothelial growth-factor receptor KDR in transfected cells显示文摘 | Warner A J Lopez-Dee J Knight E L | 2000 | Biochem J2000，347，2： | 1 |
| 16 | The curse of natural resources 显示文摘 | Sachs J D Warner A M | 2001 | European economic review2001，45，4： | 1 |
| 17 | Trends in regional inequality in China显示文摘 | Jian T Sachs J D Warner A M | 1996 | China Economic Review1996，7，1： | 1 |
| 18 | The curse of natural resources显示文摘 | Sachs J Warner A | 2001 | European Economic Review2001，，45： | 1 |
| 19 | Loss of myosin Ⅵ reduces secretion and the size of the Golgi in fibroblasts from Snell' s waltzer mice显示文摘 | WARNER C L STEWART A LUZIO J P | 2003 | EMBO J2003，22，3： | 1 |
| 20 | Microbial mercury transformation in anoxic freshwater sediments under iron-reducing and other electron-accepting conditions显示文摘 | Warner K A Roden E E Bonzongo J C | 2003 | Environmental Science & Technology2003，37，10： | 1 |
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