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| 1 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Dietary cation-anion balance and cation source effets on production and acid-base status heated stressed Cows显示文摘 | West J W Haydon K D Mullinix B G | 1992 | J Dairy Sci1992，75，： | 1 |
| 3 | Structural, spectral and thermal studies of N-2 - (4-picolyl) -and N-2 - (6-picolyl) -N' - (2-chlorophenyl) thioureas and N-2 - (6-picolyl) -N' - (2-bromophenyl) thiourea 显示文摘 | ACKERMAN L J SWEARINGEN J K WEST D X | 2002 | J Mol Struct2002，610，13： | 1 |
| 4 | Automatic detection of yellow rust in wheat using reflectance measurements and neural network显示文摘 | Moshou D Brav C West J | 2004 | Computers and Electronics in Agricultural2004，44，： | 1 |
| 5 | A ma- jor SNP haplotype of the arginine vasopressin 1B recep- tor protects against recurrent major depression 显示文摘 | Van West D Del-Favero J Aulchenko Y | 2004 | Molecular Psychiatry2004，9，3： | 1 |
| 6 | Introduction of a new rotary endodon tics system: progressively tapering files显示文摘 | West J D | 2001 | Dent T oday2001，20，： | 1 |
| 7 | TAN-1, the human homo-log of the Drosophila notch gene, is broken by chromosomaltranslocations in T lymphoblastic neoplasms显示文摘 | Ellisen L W Bird J West D C | 1991 | Cell1991，664，： | 1 |
| 8 | Behavioral correlates of individual differences in road traffic rash risk: an examination of methods and findings 显示文摘 | ELANDER J WEST R FRENCH D | 1993 | Psychology Bull1993，113，： | 1 |
| 9 | The effect of temperature on salt uptake by tomato plants with diurnal and nocturnal waterlogging of salinized rootzones显示文摘 | West D W Taylor J A | 1980 | Plant Soil1980，56，： | 1 |
| 10 | Epidemi- ology and management of Leptosphaeria maculans ( phoma stem canker) on oilseed rape in Australia, Canada and Europe显示文摘 | West J S Kharbanda P D Barbetti M 1 | 2001 | Plant Pathology2001，50，1： | 1 |
| 11 | The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched - related gene, TRC8 显示文摘 | Gemmill R M West J D Boldog F | 1998 | Proceedings of the Na- tional Academy of Sciences of the United States of Ameri- ca1998，95，16： | 1 |
| 12 | Prospective cohort study of the effectiveness of varenicline versus nicotine replacement therapy for smoking cessation in the'real world'显示文摘 | Kotz D Brown J West R | 2014 | BMC Public Health2014，14，1： | 1 |
| 13 | Delayed Newcastle disease virus replication using RNA interference to target the nucleoprotein显示文摘 | Hutcheson J M Susta L Stice S L Afonso C L West F D | 2015 | Biologicals2015，43，4： | 1 |
| 14 | Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment显示文摘 | Wang Y Risacher S L West J D | 2013 | J Alzheimers Dis2013，35，4： | 1 |
| 15 | Processing materials with microwave energy显示文摘 | Clark D E Folz D C West J K | 2000 | Materials Science & Engineering2000，287，： | 1 |
| 16 | A comparison of methods to test me- diation and other intervening variable effects 显示文摘 | MacKinnon D P Lockwood C M Hoffman J M West S G Sheets V | 2002 | Psychological Methods2002，7，1： | 1 |
| 17 | Calcium-activated tenderization of strip loin,top sirloin,and top round steaks in diverse genotypes of cattle显示文摘 | Pringle T D Harrelson J M West RL | 1999 | J Anim Sci1999，78，： | 1 |
| 18 | Preferential flow and pedotransfer functions for transport properties in sandy Kandiudults 显示文摘 | Shaw J N West L T Radcliffe D E | 2000 | Soil Science Society America Journal2000，64，： | 1 |
| 19 | Molecular pathophysiology of Parkinson's disease 显示文摘 | MOORE D J WEST A B DAWSON V L | 2005 | Annu Rev Neurosci2005，28，： | 1 |
| 20 | Effect of dietary elec- trolyte balance on performance and blood parameters of grow- ing finishing swine fed in high ambient temperatures 显示文摘 | Haydon K D West J W McCarter M N | 1990 | J Ani- mal Science1990，68，： | 1 |
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