|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 3 | Behavioral correlates of individual differences in road traffic rash risk: an examination of methods and findings 显示文摘 | ELANDER J WEST R FRENCH D | 1993 | Psychology Bull1993，113，： | 1 |
| 4 | The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched - related gene, TRC8 显示文摘 | Gemmill R M West J D Boldog F | 1998 | Proceedings of the Na- tional Academy of Sciences of the United States of Ameri- ca1998，95，16： | 1 |
| 5 | Prospective cohort study of the effectiveness of varenicline versus nicotine replacement therapy for smoking cessation in the'real world'显示文摘 | Kotz D Brown J West R | 2014 | BMC Public Health2014，14，1： | 1 |
| 6 | Laser surface cladding of satellite and satellite-SiC composite deposits for enhanced hardness and wear显示文摘 | Abbas G West D R F | 1991 | Wear1991，143，2： | 1 |
| 7 | Tumour-infihra- ting FOXP3 ( + ) lymphocytes are associated with cytotox- ic immune responses and good clinical outcome in oestro- gen receptor-negative breast cancer 显示文摘 | West N R Kost S E Martin S D | 2013 | Br J Cancer2013，108，1： | 1 |
| 8 | Novel high capacitance materials:BaTiO3:La and CaCu3Ti4O12显示文摘 | West A R Adams T B Morrison F D | 2004 | J Euro Cera Soci2004，24，： | 1 |
| 9 | Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene ( KISS1 ) 显示文摘 | Vojta P J Welch D R | 1998 | Genomics1998，54，1： | 1 |
| 10 | Decisionmaking Style,Driving Style,and Self-reported Involvement in Road Traffic Accidents显示文摘 | French D J West R J Elander J | | 0，，6： | 1 |
| 11 | Computational thermodynamic modelling of direct to blister copper smelting显示文摘 | SW1NBOURNE D R WEST R C REED M E SHEERAN A | 2011 | Mineral Processing and ExtractiveMetallurgy2011，120，1： | 1 |
| 12 | Review of crystalline lithium - ion conductors suitable for high temperature battery applications 显示文摘 | Robertson A D West A R Ritchie A G | 1997 | Solid State Ionics1997，104，12： | 1 |
| 13 | Heritability of refractive error and familial aggregation of myopia in an elderly American population 显示文摘 | Wojciechowski R Congdon N Bowie H Munoz B Gilbert D West SK | 2005 | Invest Ophthalmol Vis Sc/2005，46，5： | 1 |
| 14 | Effects of initial graft tension on knee stability after anterior cruciate ligament reconstruction using hamstring tendons: A cadaver study 显示文摘 | Boylan D Greis P E West J R | 2003 | Arthroscopy2003，19，7： | 1 |
| 15 | Behavioural characteristics and involvement in different types of traffic accident显示文摘 | Parker D West R Stradling S | 1995 | Accident Analysis & Prevention1995，27，4： | 1 |
| 16 | Giant barrier layer ca- pacitance effects in CaCu3Ti40 ceramics 显示文摘 | Adams T 13 Sinclair D C West A R | 2002 | Advanced Materials2002，14，： | 1 |
| 17 | Laser surface melting of some alloy steel 显示文摘 | Christodoulou G Walker A West D R F | 1983 | Met Technol1983，，10： | 1 |
| 18 | An upper ontology based on ISO 15926显示文摘 | BATRES R WEST M LEAL D | 2007 | Computers and Chemical Engineering2007，31，： | 1 |
| 19 | Chromosome localiza- tion and genomic structure of the Kiss-1 metastasis suppres- sor gene (Kissl) 显示文摘 | West A Vojta P J Welch D R | 1998 | Genomies1998，54，： | 1 |
| 20 | Giant barrier layercapacitance effects in CaCi^TUOu ceramics 显示文摘 | ADAMS T B SINCLAIR D C WEST A R | 2002 | Adv Mater2002，14，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员