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| 1 | 儿童重症监护中血糖控制与器官功能衰竭和病死率的关系显示文摘目的研究机械通气患几发生高血糖与器官功能衰竭的关系;介绍澳大利亚和新西兰PICU控制血糖的方法与实践。设计前瞻性队列研究。场所澳大利亚和新西兰的全部9家专业PICU病房。对象机械通气〉12h的患儿,但除外以下情况:合并糖尿病酮症酸中毒;家庭机械通气;入院时经积极心肺复苏;签有“不予复苏”医嘱。干预无。测量指标和主要结果所有患儿的血糖最长监测时间为14d,用临床和实验室指标计算儿童logistic器官功能障碍评分(PELOD)。研究中共有409例患儿使用了胰岛素。50%的患儿血糖值〉6.1mmol/L,同时89%患儿的血糖峰值〉6.1mmol/L,达到峰值的时间中位数是7h。在血糖-时间曲线上,采样时间中位数对应的曲线下面积〉6.1mmol/睹被定义为高血糖。高血糖患儿病死率为13%,而无高血糖者病死率为3%。高血糖和高PELOD(≥10)呈独立相关(OR值为3.41,95%CI:1.91~6.10)。高血糖与病死率也呈独立相关(OR值为3.31,95%CI:1.26~7.70)。早期高血糖(最初48h内)与上述预后亦相关,但与1d后PELOD加重和2d后PELOD≥10无关。5%的息儿接受了胰岛素治疗。结论高血糖在PICU较常见,通常出现较早,并与器官功能衰竭和死亡呈独立相关。但早期高血糖与晚发或加重的器官功能衰竭无关。澳大利亚和新西兰的PICU很少使用胰岛素。 | Yung M Wilkins B Slater A | 2008 | 中国小儿急救医学2008，15，2： | 8 |
| 2 | Percutaneous balloon dilatation of the mitral valve:an analysis of echocardiographic variables related to outcome and the mechanism of dilatiation显示文摘 | WILKINS G T WEYMAN A Z ABASCAL V M | 1988 | Br Heart J1988，60，4： | 2 |
| 3 | Medical student depression and its correlates across three international medical schools显示文摘BACKGROUND Medical students have high rates of depression, anxiety, and burnout that have been found to affect their empathy, professional behaviors, and performance as a physician. While studies have examined predictors for burnout and depression in the United States (US), no study, to our knowledge, has compared depression in medical students cross-culturally, or has attempted to examine the effect of factors influencing rates including burnout, exercise, stress, unmet mental health needs, and region. AIM To examine rates of depression in three international cohorts of medical students, and determine variables that may explain these differences. METHODS Convenience samples of medical students from three countries (US, China, and a Middle Eastern country whose name remains anonymous per request from the school) were surveyed in this observational study. Using the Patient Health Questionnaire-2 (PHQ-2) and a modified Maslach Burnout Inventory, depression and burnout were examined among medical students from the three cohorts (n = 473). Chi-square test and analysis of variance were used to examine differences in demographics, behavioral, and psychological variables across these three schools to identify potentially confounding descriptive characteristics. Analysis of covariance compared depression and the emotional exhaustion component of burnout identified through Principal Component Analysis across countries. Multiple linear regression was used to analyze the impact of demographic, behavioral, and psychological variables on screening positive for depression. RESULTS Medical students from the Middle Eastern country had the highest rates of positive depression screens (41.1%), defined as a PHQ-2 score of ≥ 3, followed by China (14.1 %), and then the US (3.8%). More students in the Middle Eastern school had unmet mental health needs (50.8%) than at the medical school in China (34.8%) or the school in the US (32.8%)(Pearson chi-square significance < 0.05). Thus, PHQ-2 scores were adjusted for unmet mental health needs;however, the Middle Eastern country continued to have the highest depression. Adjusting for PHQ-2 score, medical students from the US scored the highest on emotional exhaustion (a measure of burnout). Demographic variables did not significantly predict medical student depression;however, lack of exercise, unmet mental health needs, stress, and emotional exhaustion predicted nearly half of depression in these cohorts. In comparison to the US, coming from the Middle Eastern country and China predicted higher levels of depression. CONCLUSION Depression rates differ in three international cohorts of medical students. Measured factors contributed to some observed differences. Identifying sitespecific prevention and intervention strategies in medical student mental health is warranted. | Jessica A Gold Xinran Hu Gan Huang Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Mickey Trockel Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Robert M Rohrbaugh Kirsten M Wilkins | 2019 | World Journal of Psychiatry2019，9，4： | 2 |
| 4 | Complications in post-mastectomy breast reconstruction: two year results of the Michigan breast reconstruction outcome study 显示文摘 | Alderman AK Wilkins E Kim M | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 5 | Controlled release of a herbicide from matrix granules based on solvent-fractionated organosolv lignins显示文摘 | ZHAO J WILKINS R M | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 6 | From proteins to Proteomes: large scale protein identification by two dimensional electorphoresis and amino acid analysis显示文摘 | Wilkins M R Williams K L AppelR D | 1996 | Biotechnology1996，14，： | 1 |
| 7 | Should fluorescence alteration replace vitrinite reflectance as a major tool for thermal maturity determination in oil exploration? 显示文摘 | Wilkins R W T Wilmshurst J R Hladky G Ellacott M V Buckingham C P | 1995 | Organic Geochemistry1995，22，： | 1 |
| 8 | From pro- teins to proteomes:large scale protein identiWcation by two-dimensional electrophoresis and amino acid analysis 显示文摘 | Wilkins M R Pasquali C Appel R D | 1996 | Biotechnology (NY)1996，，14： | 1 |
| 9 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 10 | Progress with proteome projects:why all proteins expressed by a geneme should be identified and how to do it显示文摘 | Sanchez JC Gooley AA | 1996 | Biotechnol Genet Eng Rev1996，13，： | 1 |
| 11 | Temperature dependence of chiral discrimination in superitical fluid chromatography and high-performance liquid chromatography显示文摘 | ]Simith R J Taylor D R Wilkins S M | 1995 | J Chromatography A1995，697，： | 1 |
| 12 | H1 receptor-mediated vasodilatation contributes to postexercise hy potension显示文摘 | LOCKWOOD J M WILKINS B W HALLIWILL J R | 2005 | J Physiol2005，563，2： | 1 |
| 13 | Use of an extended Kalman filter as a robust tyre force estimator 显示文摘 | WILKIN M A MANNING W J CROLLA D C | 2006 | Vehicle System Dynamics Supplement2006，44，1： | 1 |
| 14 | Internal Control Disclosures, Monitoring, and the Cost of Debt 显示文摘 | Dhaliwal D C Hogan R Trezevant M Wilkins | 2011 | The Accounting Review2011，86，4： | 1 |
| 15 | History of water- column anoxia in the Black Sea indicated by pyrite framboids size distributions显示文摘 | WILKIN R T ARTHUR M A DEAN W E | 1997 | Earth and Planetary Science Letters1997，148，34： | 1 |
| 16 | Progress with proteome projects:why all proteins expressed by a genome should be identified and how to do it显示文摘 | Wilkins M R | | 0，，： | 1 |
| 17 | Hydrolysis of grapefruit peel waste with cellulase and pectinase enzymes显示文摘 | Wilkins M R Widmer W W Grohmann K | | 0，，08： | 1 |
| 18 | Changes in the rates of awareness,treatment and control of hypertension in Canada over the past two decades显示文摘 | Mc Alister FA Wilkins K Joffres M | 2011 | CMAJ2011，183，9： | 1 |
| 19 | Insights into the pan - microbiome: skin microbial communities of Chinese individuals differ from other racial groups 显示文摘 | Leung M H Y Wilkins D and H Lee P K | 2015 | Scientific Reports2015，5，11： | 1 |
| 20 | Protein identification and analysis tools on the ExPASy server显示文摘 | WILKINS M R GASTEIGER E BAIROCH A | 1999 | Methods Mol Biol1999，112，： | 1 |
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