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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 3 | Evaluation of fatty acid amides in the carrageenan-induced paw edema model显示文摘 | Laura E Wise Roberta Cannavacciulo Benjamin F Cravatt | | 0，，01： | 1 |
| 4 | Effects of stress on susceptibility of native channel catfish in immersion challenge with Edwardsiella ictalui显示文摘 | WISE D J SCHWEDLER T E OTIS D L | 1993 | Aquat Anim Health1993，，5： | 1 |
| 5 | Chronological gene hormone -related protein (PTHrP) in the stellate reticulum of the rat: implications for tooth eruption 显示文摘 | YAO S PAN F WISE expression of parathyroid G E | 2007 | Arch Oral Biol2007，52，3： | 1 |
| 6 | Repeated low-dose ad- ministration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotcc- tive effects显示文摘 | Steven G Kinsey Laura E Wise Divya | 2013 | J Pharmacol Exper Ther2013，345，3： | 1 |
| 7 | Placental p-gly coprotein deficiency enhance ssusceptibiliy to chemically induced birth defects in mice 显示文摘 | Lankas G R Wise L D Cartwright M E | 1998 | Reprod Toxicol1998，12，4： | 1 |
| 8 | Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle 显示文摘 | LIU D YAO S WISE G E | 2006 | Eur J Oral Sci2006，114，1： | 1 |
| 9 | Effects of Positive end-expiratory pressure on the canine venous return curve 显示文摘 | FESSLER H E BROWER R G WISE R A | 2003 | Am Rev Respir Dis2003，146，1： | 1 |
| 10 | Constitutive modeling of nanotube-reinforced polymer composites显示文摘 | Odegard G M Gates T S Wise K E | 2003 | Composites Science and Technology2003，63，： | 1 |
| 11 | Stability of cultured dental follicle cells 显示文摘 | YAO S NORTON J WISE G E | 2004 | Cell Prolif2004，37，3： | 1 |
| 12 | Choosing between Professionalism and Amateurism显示文摘 | WISE A E | 1994 | The Education Forum1994，58，： | 1 |
| 13 | Effect of number of receptors for gonadotropin-releasing hormone on the release of luteinizing hormone显示文摘 | Wise M E Nieman D Stewart J | 1984 | Biology of Reproduc- tion1984，31，5： | 1 |
| 14 | The ehemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor显示文摘 | MEISER A MUELLER A WISE E L | 2008 | J Immunol2008，180，67： | 1 |
| 15 | Interaction of ventral and orbital prefrontal cortex with inferotemporal cortex in conditional visuomotor learning显示文摘 | Bussey T J Wise S P Murray E A | 2002 | Behav Neurosci2002，116，4： | 1 |
| 16 | Synthesis of high surface area molybdenum nitride in mixtures of nitrogen and hydrogen显示文摘 | WISE R S MARKEL E J | 1994 | J Catal1994，145，2： | 1 |
| 17 | Constitutive modeling of nanotube-reinforced polymer composites显示文摘 | Odegard G M Gates T S Wise K E Park C Siochi E J | 2003 | Composites Science and Technology2003，63，： | 1 |
| 18 | The cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human lung cells显示文摘 | Sr W J Wise S S Little J E | 2002 | Mutation Research/fundamental&Molecular Mechanisms of Mutagenesis2002，517，12： | 1 |
| 19 | Tei- choic acid hydrolase activity in soil bacteria 显示文摘 | WISE E M WISE J R GLICKMAN R S | 1972 | Pro- ceedings of the National Academy of Sciences of the United States of America1972，69，1： | 1 |
| 20 | A wetlandaquifer interaction test显示文摘 | Wise W R Annable M D Walser J A E | 2000 | Journal of Hydrology2000，227，： | 1 |
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