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| 1 | 鞘内注射吗啡预处理激活大鼠δ、κ、μ受体致心肌保护显示文摘背景鞘内注射小剂量吗啡可产生与静脉注射吗啡相似的心肌保护作用,但鞘内注射吗啡预处理(IT—MPC)与缺血预处理(IPC)作用强度的差别还未知,IT-MPC是否由阿片类受体所介导也未阐明。因此,本实验比较IT—MPC与IPC作用强度差别并探讨阿片类受体的作用。方法80只SD大鼠麻醉后开胸,成功置入鞘内导管后随机分为13组(n=6—7)。IPC组接受3次5分钟缺血-5分钟再灌注的心肌IPC(阻闭左冠状动脉),随之给予30分钟缺血-2小时再灌注诱导心肌缺血再灌注(IR)损伤。IT-MPC组按剂量不同分为4个亚组(分别是0.03、0.3、3及30μg/kg),以3次5分钟注射-5分钟间停的模式平均注入鞘内,随之诱导IR损伤。静脉注射吗啡预处理组(IV-MPC)组经静脉给予吗啡300μg/kg,对照组鞘内给予10μl生理盐水。受体阻滞剂组选择在IT—MPC(3μg/kg)前分别给予选择性δ、κ、μ受体阻滞剂NTD、nor-BNI及CTOP,以评价阿片类受体亚型的作用。通过2,3,5-tripheny ltetrazolium染色,计算心肌梗死面积(IS),即梗死心肌占缺血危险区(AAR)的百分比。结果与对照组相比,鞘内注射0.3~30μg/kg吗啡降低心肌IS,3组IS/AAR分别为33%±10%(0.3μg/kg)、29%±10%(3μg/kg)、29%±16%(30μg/kg),对照组为53%±8%(P〈0.01)。IT-MPC降低心肌IS/AAR程度与IV-MPC(33%±6%,P=0.84)及IPC(22%±4%,P=0.41)相近。注射选择性受体阻滞剂后,由IT-MPC(3μg/kg)产生的心肌预处理效果降低(NTD+IT-MPC,50%±9%:nor-BNI+IT-MPc,43%±6%;CTOP+IT—MPC,53%±9%;与对照组相比,P=0.14)。结论IT—MPC产生与IPC及IV—MPC相近的心肌保护作用,其机制涉及到δ、κ、μ受体。 | Rui Li Gordon T. C. Wong Tak Ming Wong Ye Zhang, MD Zhengyuan Xia Michael G. Irwin 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 2 |
| 2 | A Review of Mucinous Cystic Neoplasms of the Pancreas Defined by Ovarian-type Stroma: Clinicopathological Features of 344 Patients显示文摘 | Brian K. P. Goh MBBS MMed (Surgery) MRCS Yu-Meng Tan BSc (Hons) MBBS FRCS Yaw-Fui A. Chung MBBS FRCS Pierce K. H. Chow MBBS FRCS PhD Peng-Chung Cheow MBBS FRCS Wai-Keong Wong MBBS FRCS London L. P. J. Ooi MBBS FRCS MD | 2006 | World Journal of Surgery2006，，12： | 2 |
| 3 | Perforation of the Gastrointestinal Tract Secondary to Ingestion of Foreign Bodies显示文摘 | Brian K.P. Goh MBBS MMed(Surgery) Pierce K.H. Chow MBBS PhD Hak-Mien Quah MBChB MMed(Surgery) Hock-Soo Ong MBBS Kong-Weng Eu MBBS London L.P.J. Ooi MBBS MD Wai-Keong Wong MBBS | 2006 | World Journal of Surgery2006，，3： | 2 |
| 4 | Implementation of Efficient B2G and V2G in Practical Cases显示文摘In this paper, building to grid(B2G) and vehicle to grid(V2G) have been defined with clear and practical understanding. Both of them are new generation technologies which are the essential part of smart city living and crowd energy clustering. Firstly, an in-detailed overview has been provided with an introduction to B2G and V2G followed by a historical overview and theoretical analysis in respect to smart city planning. Next, a review is conducted on current and previous smart living research, which deals with B2G and V2G. Efficient B2G and V2G implementations in practical cases then have been discussed. Lastly, both of these technical prospects have been analyzed in crowd energy diagram. | MD Shahrukh Adnan Khan Kazi Mahtab Kadir Md.Ibrahim Ibne Alam Md.Khairul Alam Jianhui Wong Aseef Iqbal | 2018 | Journal of Electronic Science and Technology2018，16，4： | 2 |
| 5 | Pancreatic Serous Oligocystic Adenomas: Clinicopathologic Features and a Comparison with Serous Microcystic Adenomas and Mucinous Cystic Neoplasms显示文摘 | Brian K.P. Goh MBBS MMed Yu-Meng Tan BSc MBBS Wai-Ming Yap MBBS Peng-Chung Cheow MBBS Pierce K.H. Chow MBBS PhD Yaw-Fui Alexander Chung MBBS Wai-Keong Wong MBBS London L.P.J. Ooi MBBS MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 6 | Risk factors for alcohol use, frequent use, and binge drinking among young men who have sex with men显示文摘 | Wong CF Kipke MD Weiss G | 2008 | Addict Behav2008，33，8： | 1 |
| 7 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Liu JJ Wong MD Toy WC | 2013 | J Diabetes Complications2013，27，4： | 1 |
| 8 | Relationship between his- tone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment 显示文摘 | Stewart MD Li J Wong J | 2005 | Mol Cell Biol2005，25，7： | 1 |
| 9 | The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy显示文摘 | Sandra L. Wong MD Michael J. Edwards MD Celia Chao MD Todd M. Tuttle MD R. Dirk Noyes MD David J. Carlson MD Alison L. Laidley MD Terre Q. McGlothin MD Philip B. Ley MD C. Matthew Brown MD Rebecca L. Glaser MD Robert E. Pennington MD Peter S. Turk MD Dian | 2002 | Annals of Surgical Oncology2002，，3： | 1 |
| 10 | The risk of the hemolytic - uremic syndrome after antibiotic treatment of Escheichia coli O157 :H 7 infections显示文摘 | Craig S Wong MD Srdjan Jelacic BS | 2000 | New Eng J Med2000，342，： | 1 |
| 11 | p16 INK4 and p15 INK4B alterations in primary gynecologic malignancy显示文摘 | F Wong MD Cheng TKH Cheng TH | 1997 | Gynecologic Oncology1997，65，： | 1 |
| 12 | Molecular mechanisms of germline stem cell regulation显示文摘 | Wong MD Jin Z Xie T | 2005 | Annu Rev Genet2005，39，11： | 1 |
| 13 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Liu J J Wong MD Toy WC | 2013 | J Diabetes Complications2013，27，： | 1 |
| 14 | Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment显示文摘 | Stewart MD Li J Wong J | 2005 | Mol Cell Biol2005，25，7： | 1 |
| 15 | Lower circulating irisin is associated with type 2 diabetes meUitus 显示文摘 | Liu JJ Wong MD Toy WC | 2013 | J Diabetes Complications2013，27，4： | 1 |
| 16 | Clinical ex- perience with a microvascular anastomotic device in head and neck reconstruction 显示文摘 | Delacure MD Wong RS Markowitz BL | 1995 | Am J Surg1995，170，： | 1 |
| 17 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Liu JJ Wong MD Toy WC ct al | 2013 | J Diabetes Com- plications2013，27，4： | 1 |
| 18 | Lower circulating irisinis associated with type 2 diabetes mellitus显示文摘 | Liu JJ Wong MD Toy WC | 2013 | J DiabetesComplications2013，27，4： | 1 |
| 19 | Surface motion of a semi-elliptical alluvial valley for incident plane SH waves显示文摘 | Wong HL Trifunac MD | 1974 | Bulletin of The Seismological Society of america1974，64，5： | 1 |
| 20 | Differential response of primary alveolar type Ⅰ and type Ⅱ cells to LPS stimulation显示文摘 | Wong MH Johnson MD | | 0，，： | 1 |
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