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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | A regulatory role for TRAF1 in antigen-induced apoptosis of T cells 显示文摘 | Speiser DE Lee SY Wong B | 1997 | J Exp Med1997，185，10： | 2 |
| 3 | Mutations in gidB confer low- level streptomycin resistance in Mycobacterium tuberculosis 显示文摘 | Wong SY Lee JS Kwak HK | 2011 | An- timicrob Agents Chemother2011，55，： | 1 |
| 4 | Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma 显示文摘 | Ko SY Lin SC Wong YK | 2007 | Cancer Lett2007，245，12： | 1 |
| 5 | Association of dilated retinal arteriolar caliber with early age-related macular degeneration:the Handan Eye Study显示文摘 | Yang K Zhan SY Liang YB Duan X Wang F Wong TY | | 0，，5： | 1 |
| 6 | Pharmacokinetics of zileuton and it metabolites in subjects with renal impairment显示文摘 | Wong S Chu SY | 1997 | Clin Pharmacol Ther1997，61，2： | 1 |
| 7 | Novel mutations in ndh in Isoniazidresistant Mycobacterium tuberculosis Isolates 显示文摘 | Lee AS Teo AS Wong SY | 2001 | Antimicrob Agents Chmother2001，45，7： | 1 |
| 8 | A prospective con- trolled double - blind of great auricular never p reservation at parotidectomy显示文摘 | Yau Hui David SY Wong Ling - Wong | 2003 | The American Journal of Surgery2003，185，： | 1 |
| 9 | High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease显示文摘 | Ng FH Wong SY Chang CM | 2003 | Aliment Pharmacol Ther2003，18，： | 1 |
| 10 | Study on refrigerant circuitry of condenser coils with an energy destruction analysis显示文摘 | Liang SY Wong TN Nathan GK | 2000 | Applied Thermal Engineering2000，20，6： | 1 |
| 11 | Assessment of the se verity of dementia: validity and reliability of the Chinese (Cantonese) version of the Hierarchic Dementia Scale (CV- HDS) 显示文摘 | Poon VW Lam LC Wong SY | 2008 | IntJ Geriatr Psychiatry2008，23，9： | 1 |
| 12 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 13 | Hypofractionated stereotactic radio- therapy for medically inoperable stage I non-small cell lung cancer- report on clinical outcome and dose to critical organs显示文摘 | Ng AW Tung SY Wong VY | 2008 | Radiother On- col2008，87，1： | 1 |
| 14 | QF-PCR-based prenatal detection of aneuploidy in a southeast Asian population 显示文摘 | Quaife R Wong LF Tan SY | 2004 | Prenat Diagn2004，24，： | 1 |
| 15 | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium -dependent relaxation in rat aorta显示文摘 | Wong WT Ng CH Tsang SY | 2009 | Nutr Metab Cardiovase Dis2009，21，3： | 1 |
| 16 | Gastrointestinal bleed ing in patients receiving a combination of aspirin, clopi dogrel,and enoxaparin in acute coronary syndrome 显示文摘 | Ng FH Wong SY Lam KF | 2008 | Am J Gastroenterol2008，103，4： | 1 |
| 17 | High incidence of clopidogrel associated gastrointestinal bleeding in patients with previous peptic ulcer disease显示文摘 | Ng FH Wong SY Chang CM | 2003 | Aliment Pharmacul Ther2003，18，4： | 1 |
| 18 | Thoracic myelopathy secondary to ligamen- tum flavum ossification显示文摘 | Fong SY Wong HK | 2004 | Ann Acad Med Singapore2004，33，3： | 1 |
| 19 | Exon3 polymorph is ms of dopamine D4receptor (DRD4) gene and attention deficit hyperactivity disor- der in Chinese children 显示文摘 | Cheuk DK Li SY Wong V | 2006 | Am J Med Genet B Neuropsychiatr Genet2006，141，8： | 1 |
| 20 | Aberrant promoter methylation of the retinoic acid receptor alpha gene in acμte promyelocytic leμkemia显示文摘 | Chim CS Wong SY Pang A | 2005 | Leμkemia2005，19，12： | 1 |
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