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| 1 | Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong显示文摘 | Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong Siu Wai Tang | 2016 | Journal of Geriatric Cardiology2016，13，5： | 5 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo显示文摘胀大导致 Cl 电流的激活(我 Cl,胀大 ) 在新生的组织缺氧局部缺血期间(嗨) 可以导致大脑损坏。Hypoxic-ischemic 大脑损害在出生不满一月的婴儿以及尖锐死亡引起长期的神经病学的病态。在这研究,我们调查了角色我 Cl,胀大在用选择 blocker 的 hypoxic-ischemic 大脑损害的 , 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl ) oxybutyric 酸(DCPIB ) 。在主要有教养的外皮的神经原, 30% 张力减退的答案的灌注激活我 Cl,胀大是的 , 完全由 DCPIB (10 mol/L ) 的申请堵住了。角色我 Cl,胀大在在 vivo 的新生的 hypoxic-ischemic 大脑损害的 在一个修改新生的 hypoxic-ischemic 大脑损害模型被评估。在收到 ischemic 侮辱前,老鼠小狗与 DCPIB 被注射(10 mg/kg, ip ) 。我们发现有 DCPIB 的那个预告的处理显著地减少了用 TTC 染色, Nissl 染色和整个大脑成像估计的大脑损坏,并且改进了在 neurobehavioural 测试评估的感觉运动、门厅的恢复结果(即趋地性 reex,和峡谷回避 reex ) 。这些结果证明 DCPIB 在新生的 hypoxic-ischemic 大脑损害上有 neuroprotective 效果,并且 I Cl,胀大 可以为 hypoxic-ischemic encephalopathy 的处理用作一个治疗学的目标。 | Raymond WONG Ahmed ABUSSAUD Joseph WH LEUNG Bao-feng XU Fei-ya LI Sammen HUANG Nai-hong CHEN Guan-lei WANG Zhong-ping FENG Hong-shuo SUN | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 4 | Significance of a positive oesophageal margin in stomach cancer 显示文摘 | Chan WH Wong WK Khin IW | 2000 | Ausl NIJ Surg2000，70，10： | 1 |
| 5 | Relationship between autoantibody clustering and clinical subsets in SLE: clus- ter and ssociation analyses in Hong Kong Chinese 显示文摘 | Li PH Wong WH Lee TL | 2013 | Rheumatology (Oxford)2013，52，2： | 1 |
| 6 | Sulphite oxidase gene expression in human brain and in other human and rat tissues 显示文摘 | Woo WH Yang H Wong KP | 2003 | Bioehem Biophys Res Commun2003，305，3： | 1 |
| 7 | Epidermal growth factor and it receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobactor pylori eradication显示文摘 | Wong BC Wong WP So WH | 2001 | Alimnt Pharmacol Ther2001，15，9： | 1 |
| 8 | Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart显示文摘 | Tang WH Wu S Wong TM | | 0，，5： | 1 |
| 9 | Association of interleukin-10 pro- moter polymorphisms with systemic lupus erythematosus 显示文摘 | Chong WP Ip WK Wong WH | 2004 | Genes Immun2004，5，6： | 1 |
| 10 | Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment显示文摘 | Cheong KF Wong WH | 2000 | Br J Anaesth2000，84，1： | 1 |
| 11 | Association between antiphospholipid antibodies and cardiac abnormalities in pa tients with systemic lupus erythematosus显示文摘 | Leung WH Wong KL Lau CP | 1990 | Am J Med1990，89，： | 1 |
| 12 | One pot phase transfer synthesis of O-alkyl, S-methyl dithioearbonates (xanthates) 显示文摘 | Lee AWM Chan WH Wong HC | 1989 | Synth Commun1989，19，34： | 1 |
| 13 | Filtering of ineffective siRNAs and improved siRNA design tool显示文摘 | SM Yiu Prudence WH Wong TW Lam | 2005 | Bioinformatics2005，21，2： | 1 |
| 14 | One week ranitidine bismuth citrate - based triple therapy for the eradication of Helicobacter pylori in Hong Kong with hing prevalence of metronidazole resistance显示文摘 | Wong BCY Wong WM Wang WH | 2001 | Aliment Pharmacology2001，15，： | 1 |
| 15 | Pain on injection of rocuronium : influence of two doses of lidocaine pretreatment 显示文摘 | Cheong KF Wong WH | 2000 | Br J Anaesth2000，84，1： | 1 |
| 16 | Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus显示文摘 | Leung WH Wong KL Lau CP | 1990 | Am J Med1990，89，： | 1 |
| 17 | Chylothorax in children after congenital heart surgery显示文摘 | Chan SY Lau W Wong WH | 2006 | Ann Thorac Surg2006，82，5： | 1 |
| 18 | Gene expressions during the development and sexual differentiation of the olfactory bulb in rats显示文摘 | Wong CC Pooh WH Tsim TY | 2000 | Brain Res Dev Brain Res2000，119，2： | 1 |
| 19 | Model- based analysis of oligonucleotlde arrays: expression index computation and outlier detection显示文摘 | Li C Wong WH | 2001 | Proc Natl Acad Sci USA2001，98，1： | 1 |
| 20 | Beneficial effects of cholesterol-lowering therapy on coronary endotheliurn-de-pendent relaxation in hypercholesterolaemic patients显示文摘 | Leung WH Lau CP Wong CK | 1993 | Lancet1993，41，8859： | 1 |
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