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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Sorption of polynuclear aromatic hydrocarbons by sediments and soil 显示文摘 | MEANS J C WOOD S HASSETT J J | 1980 | Environ Sci Technol1980，14，12： | 1 |
| 3 | Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment 显示文摘 | Dennog C Gedik C Wood S | 1999 | Mutat Res1999，431，2： | 1 |
| 4 | Effects of dimethyl sulfoxide and glycine on cryopreservation induced damage ot plasma membranes and mitochondria to striped bass (Morone saxatilis) sperm显示文摘 | He S Woods L C | 2004 | Cryobiology2004，48，3： | 1 |
| 5 | The influence of diabetes mellitus in patients undergoing coronary artery bypass graft surgery: a prospective cohort study显示文摘 | Woods S E Eppley C Engel A | 2008 | Am Surg2008，74，9： | 1 |
| 6 | Central nervous system control of food intake显示文摘 | Schwartz M W Woods S C Porte D Jr | 2000 | Nature2000，404，： | 1 |
| 7 | The limits of resolution of Zero-phase wavelets显示文摘 | Kalweit R S Wood L C | 1982 | Geophysics1982，47，7： | 1 |
| 8 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | Marx M C Wood M Jarvis S C | 2001 | Soil Biology & Biochemistry2001，，33： | 1 |
| 9 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 10 | An Automated Method to Calibrate Industrial Robots Using a Virtual Closed Kinematic Chain显示文摘 | Gatla C S Lumia R Wood J Starr G | 2007 | IEEE transactions on robotics and automation2007，11，23： | 1 |
| 11 | A microplate fluorimetric assay for the study of enzyme diversity in soils显示文摘 | Marx M C Wood M Jarvis S C | 2001 | Soil Biology and Biochem- istry2001，33，1213： | 1 |
| 12 | Hyper-X research vehicle experimental aerodynamics test program overview显示文摘 | HOLLAND S D WOODS W C ENGELUND W C | 2001 | Journal of Spacecraft and Rockets2001，38，6： | 1 |
| 13 | Does dietary Ca protect against toxicity of a low dietborne Cd exposure to the rainbow trout?显示文摘 | Ng T Y T Klinck J S Wood C M | 2009 | Aquatic Toxicology2009，91，1： | 1 |
| 14 | Growth hormone receptor and serum binding protein : purification, cloning and expression 显示文摘 | Leung D W Spencer S A Cachianes G Hammonds R G Collins C Henzel W J Bamant R Waters M J Wood W I | 1987 | Nature1987，330，： | 1 |
| 15 | Effect of urea and by-products on the in vitro fermentation of untreated and urea treated finger millet straw显示文摘 | Sampath K T Wood C D Prasad C S | 1995 | J Sci Food Agric1995，67，： | 1 |
| 16 | Erosion and erosion-corrosion performance of cast and thermally sprayed nickel-aluminium bronze显示文摘 | BARIK R C WHARTON J A WOOD R J K TAN K S STOKES K R | 2005 | Wear2005，259，： | 1 |
| 17 | Physi- cal and numerical modelling of thunderstorm damburst 显示文摘 | Wood G S Kwok K C S Motteram N A | 2001 | Journal of Wind Engineering and Inolustrial Aero- dynamics2001，89，6： | 1 |
| 18 | A least error square technique for determine power system frequency显示文摘 | SACHDEV M S WOOD H C JOHNSON N | 1985 | IEEE Trans on Power Apparatus and Systems1985，104，2： | 1 |
| 19 | Ego depletion and the strength model of self-eontrol:A meta-analysis显示文摘 | HAGGER M S WOOD C STIFF C | 2010 | Psyehol Bull2010，136，4： | 1 |
| 20 | Idendfication,properties,anddifferential counts of cell populations using electron microscopy of dry cows secretions, colostrum and milk from normal cows 显示文摘 | Lee C S Wooding F B Kemp P | 1980 | J Dairy Res1980，47，： | 1 |
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