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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Dendrite crystallization: Numerical study &the one-sided model显示文摘 | SAITO Y WOOD G HMULLER K | 1987 | Phys Rev Lett1987，58，： | 1 |
| 3 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Kumar A Roberts D Wood K E | 2006 | Crit Care Med2006，34，6： | 1 |
| 4 | The sand erosion performance of coatings 显示文摘 | Wood R J K | 1999 | Mater1999，20，： | 1 |
| 5 | Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast显示文摘 | VOTrERO E BALGI A WOODS K | 2006 | Biotechnol J2006，1，3： | 1 |
| 6 | Exporting Manufacture: Human Resources, Natural Resources and Trade Policy显示文摘 | Wood A Bcrge K | 1997 | Journal of Development Studies1997，，34： | 1 |
| 7 | Regulatory T cells in transplantation tolerance显示文摘 | Wood K J Sakaguchi S | 2003 | Nat Rev Immunol2003，3，3： | 1 |
| 8 | Development of a Functional Basis for Design显示文摘 | Stone R B Wood K L | 2000 | Journal of Mechanical Design2000，122，4： | 1 |
| 9 | Strain softening and parameter for sand modeling显示文摘 | WOOD D M BELKHEIR K SHEN C K | 1994 | Geo- technique1994，44，2： | 1 |
| 10 | Suppression of tu- morigenicity of breast cancer cells by an epithelial cell adhe- sion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains显示文摘 | LUO W WOOD C G EARLEY K | 1997 | Oncngene1997，14，14： | 1 |
| 11 | Modifiable risk factors for asthma morbidity in Bronx versus other inner - city children 显示文摘 | Warman K Silver EJ Wood PR | 2009 | J Asthma2009，46，10： | 1 |
| 12 | Film formation and detachment during anodizing of Al-Mg alloys显示文摘 | ZHOU X THOMPSON G E SKELDON P WOOD G C SHIMIZU K HABAZAKI H | 1999 | Corrosion Science1999，41，8： | 1 |
| 13 | Effects of spatial variabilily and scale with implication to hydrologic modeling显示文摘 | Wood E F Sivapalan M Bern K J el at | 1988 | Journal of Hydrology1988，102，： | 1 |
| 14 | Association between blood pressure: the treatment of hypertension,and cardiovascular risk factors in women 显示文摘 | Nanchahal K Ashton WD Wood DA | 2000 | J Hypertens2000，18，： | 1 |
| 15 | In situ hybridization studies of metalloproteinases 2 and 9 and TIMP-1 and TIMP-2 expression in human prostate cancer显示文摘 | Wood M Fudge K Mohler JL | 1997 | Clin Exp Metastasis1997，15，3： | 1 |
| 16 | Inhibitting sulfate-reducing bacteria in biofilms by expressing the antimibrobial peptides indolicidin and bactenecin显示文摘 | Jayaraman A Mansfeld FB Wood T K | 1999 | J Ind Microb1999，22，3： | 1 |
| 17 | Toward a Theory of Stakeholder Identification And Salience:Defining The Principle of Who and What Really Counts显示文摘 | RONALD K MITCHELL BRADLEY R AGLE DONNA J WOOD | 1997 | Academy of Management Review1997，22，4： | 1 |
| 18 | The use of bivalves as bio-indicators in the assessment of marine pollution along a coastal area 显示文摘 | Yusof A M Yanta N F Wood A K H | 2004 | Journal of Radioanalytical and Nuclear Chemistry2004，259，1： | 1 |
| 19 | Flow analysis of natural rubber in a capillary rheometer( 1 ) : Rheological behavior and flow visualization in the barrel显示文摘 | Sombatsompop N Tan M C Wood A K | 1997 | Polym Eng Sci1997，37，2： | 1 |
| 20 | Optimum tests conditions for attaining u- niforrn rolling abrasion in ball cratering tests on hard coating 显示文摘 | Bose K Wood R J K | 2005 | Wear2005，258，： | 1 |
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