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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Further aspects of design by P-Delta method显示文摘 | Wood B R Beaulieu D Adams P F | 1976 | Journal of the Structural Division ASCE1976，102，3： | 1 |
| 4 | Effects of nitrogen and sulfur fertilizer on protein composition,mixing requirements,and dough strength of four wheat cultivars显示文摘 | Wooding A R Kavale S Macritchie F | 2000 | Cereal Chem2000，77，6： | 1 |
| 5 | Laparoscopic partial nephrectomy of solid renal masses without hilar clamping using a monopolar radio frequency device显示文摘 | Urena R Meudez F Woods M | 2004 | J Urol2004，171，3： | 1 |
| 6 | Effects of age of acquisi- tion, and repetition priming on object naming 显示文摘 | Barry C Johnston R A Wood R F | 2006 | Visual Cognition2006，13，7： | 1 |
| 7 | Increasing flexural capacity of reinforced concrete beams using carbon fibre-reinforced polymer composites 显示文摘 | Brena S F Bramblett R M Wood S L | 2003 | ACI Structure Journal2003，100，1： | 1 |
| 8 | Gold enhanced spectroelectrochemical investigation of 2-mercaptobenzothiazole, isopropyl xanthate and butylethoxycarbonylthiourea adsorption on minerals显示文摘 | HOPE G A BUCKLEY F M MUNCE C G WOODS R | 2007 | Minerals Engineering2007，20，10： | 1 |
| 9 | Hydro-climatological trends in the continental United States: 1948 -88 显示文摘 | Lettenmaier D P Wood E F Wallis J R | 1994 | Journal of Climate1994，7，： | 1 |
| 10 | Light-dependent GTP-hinding protein in squid photoreceptors显示文摘 | RPBOMSPN P R WOOD S F SZUTS E Z | 1990 | Biochemical Journal1990，272，： | 1 |
| 11 | Modern approaches to marine antifouling coatings显示文摘 | Chambers L D Stokes K R Walsh F C Wood R J K | 2006 | Surface and Coatings Technology2006，201，： | 1 |
| 12 | Logistics planning under uncertainty for disposition of radioactive wastes 显示文摘 | List George F Wood Bryan Turnquist Mark A Nozick Linda K Jones Dean A Lawton Craig R | 2006 | Computers and Operations Research2006，33，3： | 1 |
| 13 | Isolation and characterization of a Vibrio alginolyticus mutant that overproduces extracellular proteases显示文摘 | DEANE S M ROBB F T WOODS D R | 1986 | Gen Microbio1986，132，： | 1 |
| 14 | Increasing flexural capacity of reinforced concrete beams using carbon fiber-reinforced polymer composites显示文摘 | S F Brena R M Bramblett S Wood | 2003 | ACI Structural Journal2003，100，1： | 1 |
| 15 | Production and activation of an SDS-resistant alkaline serine exoprotease of Vibrio lginolyticus显示文摘 | DEANE S M ROBB F T WOODS D R | 1987 | Gen Microbiol1987，133，： | 1 |
| 16 | Spatial organization of calcium signaling involved in cell volume control in the Fucus rhizoid 显示文摘 | Taylor A R Manison N F H Fernandez C Wood J B C | 1996 | The Plant Cell1996，8，11： | 1 |
| 17 | Hydroclimatologieal trends in the continental United States 1948--1988 显示文摘 | Lettenmaier D P Wood E F Wallis J R | 1994 | Journal of Climate1994，7，： | 1 |
| 18 | Effects of breed diet and muscle on fat deposition and eating quality in pigs 显示文摘 | Wood D Nute G R Richardson R I Whittington F M Southwood O Plastow G Mansbridge R da Costa N Chang K C | 2004 | Meat Science2004，67，4： | 1 |
| 19 | Evaluation of AMSR-E soil moisture results using the in-situ data over the Little River Experimental Watershed, Georgia显示文摘 | Alok K Sahoo Paul R Houser Craig Ferguson Erlc F Wood | 2008 | Remote Sensing of Environment2008，112，： | 1 |
| 20 | Virtual network computing显示文摘 | RICHARDSON T STAFFORD F Q WOOD K R | 1998 | IEEE Internet Computing1998，2，1： | 1 |
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