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| 1 | Current concepts in total femoral replacement显示文摘Total femoral replacement(TFR) is a salvage arthroplasty procedure used as an alternative to lower limb amputation. Since its initial description in the mid-20^(th) century, this procedure has been used in a variety of oncologic and non-oncologic indications. The most compelling advantage of TFR is the achievement of immediate fixation which permits early mobilization. It is anticipated that TFR will be increasingly performed as the rate of revision arthroplasty rises worldwide. The existing literature is mainly composed of a rather heterogeneous mix of retrospective case series and a wide assortment of case reports. Numerous TFR prostheses are currently available and the surgeon must understand the unique implications of each implant design. Long-term functional outcomes are dependent on adherence to proper technique and an appropriate physical therapy program for postoperative rehabilitation. Revision TFR is mainly performed for periprosthetic infection and the severe femoral bone loss associated with aseptic revisions. Depending on the likelihood of attaining infection clearance, it may sometimes be advisable to proceed directly to hip disarticulation without attempting salvage of the TFR. Other reported complications of TFR include hip joint instability, limb length discrepancy, device failure, component loosening, patellar maltracking and delayed wound healing. Further research is needed to better characterize the long-term functional outcomes and complications associated with this complex procedure. | Deepak Ramanathan Marcelo BP Siqueira Alison K Klika Carlos A Higuera Wael K Barsoum Michael J Joyce | 2015 | World Journal of Orthopedics2015，6，11： | 6 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | Construction and performance of a thermoacoustic refrigerator显示文摘 | Tijani M E H Zeegers J C H de Waele A T A M | 2002 | Cryogenics2002，42，1： | 1 |
| 4 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 5 | Intra-abdominal hypertension and abdominal compartment syndrome 显示文摘 | De Waele J J De Laet 1 Kirkpatrick AW | 2011 | Am J Kidney Dis2011，57，1： | 1 |
| 6 | Phenytoin intoxication in critically ill patients显示文摘 | de Schoenmakere G de Waele J Terryn W | 2005 | Am J Kidney Dis2005，45，1： | 1 |
| 7 | Temporary abdominal clo- sure techniques显示文摘 | de Waele J J Leppaniemi A K | 2011 | Am Surg2011，77，1： | 1 |
| 8 | The impact of body position on intra - abdominal pressure measurement: a multi - center analysis 显示文摘 | CHEATHAM ML DE WAELE J J DE LAET I | 2009 | Crit Care Med2009，37，7： | 1 |
| 9 | |ntra-abdominal hypertension in acute pancreatitis 显示文摘 | De Waele J J Leppaniemi AK | 2009 | World J Surg2009，33，6： | 1 |
| 10 | The effect of different reference transducer positions on intra-abdominal pressure measurement: a multicenter analysis显示文摘 | De Waele J J De Laet I De Keulenaer B | 2008 | intensive Care Med2008，34，7： | 1 |
| 11 | Geomorphology and geomorphological heritage of the Ifrane~Azrou region (Middle Atlas, Morocco)显示文摘 | Waele J D Melis M T | 2009 | Environmental Geology2009，58，3： | 1 |
| 12 | Steatohepatitis in obese individuals显示文摘 | Wael I Youssef Arthur J McCullough | 2002 | Best Practice & Research Clinical Gastroenterology2002，，5： | 1 |
| 13 | Intra- abdominal Hypertension and Abdominal Compartment Syndrome显示文摘 | De Waele J J De Laet I Kirkpatrick AW | 2011 | Am J Kidney Dis2011，57，1： | 1 |
| 14 | Direct observation of plasmonic modes in Au nanowires using high-resolution cathodoluminescence spectroscopy 显示文摘 | VESSEUR E J R DE WAELE R KUTTGE M | 2007 | Nano Lett2007，7，9： | 1 |
| 15 | lntra-abdominal hy- pertension and the abdominal compartment syndrome: updated con- sensus definitions and clinical practice guidelines from the World So- ciety of the Abdominal Compartment Syndrome'显示文摘 | Kirkpatrick AW Roberts DJ De Waele J | 2013 | Intensive Care Med2013，39，7： | 1 |
| 16 | Extrapancreatic inflammation on abdominal computed tomography as an early predictor of disease severity in acute pancreatitis: evaluation of a new scoring system显示文摘 | De Waele J J Delrue L Hoste E A | 2007 | Pancreas2007，34，2： | 1 |
| 17 | Intra-abdominal hypertension and the abdominal compartment syndrome:up- dated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome 显示文摘 | Kirkpatrick AW Roberts DJ De Waele J | 2013 | Intensive Care Med2013，39，7： | 1 |
| 18 | Nonoperative management of intra-abdominal hypertension and abdominal compartment syndrome: Evolving concepts 显示文摘 | De Keulenaer BL De Waele J J Malbrain ML | 2011 | Am Surg2011，77，1： | 1 |
| 19 | Intra - abdomi- nal hypertension and the abdominal compartment syndrome: upda- ted consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome 显示文摘 | Kirkpatrick AW Roberts DJ De Waele J | 2013 | Intensive Care Med2013，39，7： | 1 |
| 20 | Optical measurement of target displacement and velocity in bird strike simulation experiments显示文摘 | DEGRIECK J VERLEYSEN P WAELE W D | 2003 | Measurement Science and Technology2003，，14： | 1 |
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