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| 1 | Vegetation and soil carbon storage in China显示文摘This study estimated the current vegetation and soil carbon storage in China using a biogeochemical model driven with climate, soil and vegetation data at 0.5°latitude-longitude grid spatial resolution. The results indicate that the total carbon storage in China's vegetation and soils was 13.33 Gt C and 82.65 Gt C respectively, about 3% and 4% of the global total. The nationally mean vegetation and soil carbon densities were 1.47 kg C/m2 and 9.17 kg C/m2, respectively, differing greatly in various regions affected by climate, vegetation, and soil types. They were generally higher in the warm and wet Southeast China and Southwest China than in the arid Northwest China; whereas vegetation carbon density was the highest in the warm Southeast China and Southwest China, soil carbon density was the highest in the cold Northeast China and southeastern fringe of the Qinghai-Tibetan Plateau. These spatial patterns are clearly correlated with variations in the climate that regulates plant growth and soil organic matter decomposition, and show that vegetation and soil carbon densities are controlled by different climatic factors. | LI Kerang, WANG Shaoqiang & CAO MingkuiInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Department of Geography, Maryland University, College Park,MD 20742, USA Correspondence should be addressed to Li Kerang | 2004 | Science China Earth Sciences2004，47，1： | 60 |
| 2 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 3 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 4 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 5 | Retrieving crop leaf area index by assimilation of MODIS data into a crop growth model显示文摘Leaf area index (LAI) is an important parameter in monitoring crop growth. One of the methods for retrieving LAI from remotely sensed observations is through inversion of canopy reflectance models. Many model inversion methods fail to account for variable LAI values at different crop growth stages. In this research, we use the crop growth model to describe the LAI changes with crop growth, and consider a priori LAI values at different crop growth stages as constraint information. The key approach of this research is to assimilate multiple canopy reflectance values observed at different growth stages and a priori LAI values into a coupled crop growth and radiative transfer model sequentially using a variational data assimilation algorithm. Adjoint method is used to minimize the cost function. Any other information source can be easily incorporated into the inversion cost function. The validation results show that the time series of MODIS canopy reflectance can greatly reduce the uncertainty of the inverted LAI values. Compared with MODIS LAI product at Changping and Shunyi Counties of Beijing, this method has significantly improved the estimated LAI temporal profile. | WANG DongWei1,2,3, WANG JinDi1,2 & LIANG ShunLin4 1 State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications, CAS, Beijing 100875, China 2 School of Geography, Beijing Key Laboratory of Environmental Remote Sensing and Digital City, Beijing Normal University, Beijing 100875, China 3 Haihe River Water Conservancy Commission, Tianjin 300170, China 4 Department of Geography, University of Maryland, College Park, MD 20742, USA | 2010 | Science China Earth Sciences2010，53，5： | 8 |
| 6 | Physicochemical and Sensory Properties of japonica Rice Varied with Production Areas in China显示文摘Northeast of China and Jiangsu Province are major production areas of japonica rice in China.Rice from northeast of China is well-known for its good-eating and appearance quality,and that from Jiangsu Province is viewed as inferior.However,little is known concerning the difference in physicochemical and sensory properties of rice between the major two production areas.Analysis of 16 commercial rice samples showed marked differences in physicochemical properties,including chalky grain rate,contents of amylose and protein and pasting properties between the two main areas.Northeastern rice contained more shortchain amylopectin as compared with Jiangsu rice.However,Jiangsu rice is comparable to northeastern rice in terms of sensory quality including overall acceptability and textural properties of springiness,stickiness and hardness as evaluated by trained panel.Our results indicated the limitation of conventional index of physicochemical properties,and suggested the necessity of identification of new factors controlling rice sensory property.In addition,the taste analyzer from Japan demonstrates limitation in distinguishing the differences between northeastern and Jiangsu rice,and therefore needs localization to fit China. | YANG Xiao-yu LIN Zhao-miao LIU Zheng-hui Md A Alim BI Jun-guo LI Gang-hua WANG Qiang-sheng WANG Shao-hua DING Yan-feng | 2013 | Journal of Integrative Agriculture2013，12，10： | 8 |
| 7 | Trends in Extremes of Surface Humidity, Temperature, and Summertime Heat Stress in China显示文摘In the past half century, the mean summertime temperature in China has increased, with nights warm- ing more than days. Using surface station observations, we show that the frequency of extreme heat-stress events in China, caused by extremely hot and humid days as well as by heatwaves lasting for a few days, has increased over the period from 1951 to 1994 When humidity is high, hot weather can cause heat stress in humans. The increased heatrstress trend may pose a public health | Julian X.L. Wang and Dian J. Gaffen NOAA/ Air Resources Laboratory, Silver Spring, MD, 20910, USA | 2001 | Advances in Atmospheric Sciences2001，18，5： | 6 |
| 8 | Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy显示文摘 | Gauri R. Varadhachary MD Eric P. Tamm MD James L. Abbruzzese MD Henry Q. Xiong MD Christopher H. Crane MD Huamin Wang MD Jeffrey E. Lee MD Peter W. T. Pisters MD Douglas B. Evans MD Robert A. Wolff MD | 2006 | Annals of Surgical Oncology2006，，8： | 4 |
| 9 | Rapid Detection of Wheat Blast Pathogen Magnaporthe oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology显示文摘Wheat blast,caused by the fungus Magnaporthe oryzae Triticum(MoT)pathotype,is a devastating disease persistent in South America and Bangladesh.Since MoT generally fails to cause visual symptoms in wheat until the heading stage when the infection would have advanced,disease control by fungicide application solely based on the detection of visual symptoms is ineffective.To develop an accurate and sensitive method to detect MoT at the seedling and vegetative stages for disease control,we sequenced the genomes of two MoT isolates from Brazil and identified two DNA fragments,MoT-6098 and MoT-6099,that are present in the MoT genome but not in the genome of the rice-infecting Magnaporthe oryzae Oryzae(MoO)pathotype.Using polymerase chain reaction(PCR),we confirmed the specificity of the two markers in 53 MoT and MoO isolates from South America and Bangladesh.To test the efficiency of the two markers,we first established a loop-mediated isothermal amplification(LAMP)method to detect MoT at isothermal conditions,without the use of a PCR machine.Following this,we used the Cas12a protein and guide RNAs(gRNAs)to target the MoT-6098 and MoT-6099 sequences.The activated Cas12a showed indiscriminate single-stranded deoxyribonuclease(ssDNase)activity.We then combined targetdependent Cas12a ssDNase activation with recombinase polymerase amplification(RPA)and nucleic acid lateral flow immunoassay(NALFIA)to develop a method that accurately,sensitively,and cost-effectively detects MoT-specific DNA sequences in infected wheat plants.This novel technique can be easily adapted for the rapid detection of wheat blast and other important plant diseases in the field. | Houxiang Kang Ye Peng Kangyu Hua Yufei Deng Maria Bellizzi Dipali Rani Gupta Nur Uddin Mahmud Alfredo S.Urashima Sanjoy Kumar Paul Gary Peterson Yilin Zhou Xueping Zhou Md Tofazzal Islam Guo-Liang Wang | 2021 | Engineering2021，7，9： | 4 |
| 10 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 11 | Clinical Impact of Positive Surgical Margin Status on Gastric Cancer Patients Undergoing Gastrectomy显示文摘 | Shang-Yu Wang MD Chun-Nan Yeh MD Hsiang-Lin Lee MD Yu-Yin Liu MD Tzu-Chieh Chao MD PhD Tsann-Long Hwang MD FACS Yi-Yin Jan MD FACS Miin-Fu Chen MD FACS | 2009 | Annals of Surgical Oncology2009，，10： | 2 |
| 12 | Advances in the development of molecular genetic tools for Mycobacterium tuberculosis显示文摘Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference(CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed. | Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mahmudul Islam H.M.Adnan Hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang | 2018 | Journal of Genetics and Genomics2018，45，6： | 2 |
| 13 | Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine显示文摘 | HongSheng Wang MD PhD Nobuhiro Ohkohchi MD PhD Yoshitaka Enomoto MD Masahiro Usuda MD Shigehito Miyagi MD Hiroo Masuoka MD Satoshi Sekiguchi MD Naoki Kawagishi MD Keisei Fujimori MD Akira Sato MD Susumu Satomi MD PhD | 2006 | World Journal of Surgery2006，，11： | 2 |
| 14 | Suitability of 7th UICC N Stage for Predicting the Overall Survival of Gastric Cancer Patients After Curative Resection in China显示文摘 | Jingyu Deng MD Han Liang MD Dan Sun MS Dianchang Wang MD Yi Pan MD | 2010 | Annals of Surgical Oncology2010，，5： | 2 |
| 15 | Angioplasty with Stent for Symptomatic Intracranial Stenosis Trial I (ASSIT-Ⅰ) Study显示文摘Background and Purpose Annual stroke rates might be as high as 10% to 24% in patients with symptomatic intracranial stenosis on best medical therapy. Angioplasty with stent for symptomatic intracranial stenosis trial Ⅰ (ASSIST-Ⅰ) was a prospective and nonrandomized feasibility and safety study to evaluate the APOLLO Stent System for treatment of symptomatic intracranial artery stenosis, and prepare for ASSIST Ⅱ-a prospective, multicenter,and randomized controlled-study. The APOLLO stent delivery system (MicroPort Medical [Shanghai] Limited Co.), specifically designed for intracranial artery stenosis, consists of a stent and a balloon and a rapid-exchange delivery catheter. The stent is made of 316L stainless steel, with diameters of 2.0 to 4.0 mm and length of 8 mm or 13 mm. Only two links connect the rings of 1 mm in length, rendering the stent a good flexibility enough to navigate tortuous intracranial vessels. The nominated pressure of the stent is designed at 6 atm to reduce the risk of occlusion to side branches and perforators and rupture and dissection of target vessel. The crimping technique is applied in this system, insuring a compact ability of stent so wonderful that the struts of stent do not lift when the stent negotiates a turn, which lessen the likelihood of vessel wall injury and stent migrating. Materials and methods Thirty-four patients with 35 symptomatic intracranial stenoses of ≥50%, which resulted in transient ischemic attacks (TIAs [23 lesions /22 patients]) and minor stroke (7 lesions/7 patents), and both TIAs and stroke (5 lesions/ 5 patients), and with 1 asymptomatic severe stenosis, were enrolled in ASSIST-Ⅰ from December 10, 2003 to August 12, 2004. Their age was 54.3 years±SD of 9.49, three patients were male, and all had ≥1 risk factors of atherosclerosis. Patients received the evaluation of National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale (mRS )and Barthel idex (BI) before and one-, three-, six-, and 12-month after the procedure. Results Stent success, defined as stent-assisted angioplasty successfully, resulting in ≤20% residual stenosis, was obtained in 35 lesions ( 97.2%, 35/36) and 33 patients ( 97.1%, 33/34). The stenosis rate of pre- and post -procedure was 80.5%± SD of 12.65 and 7.4%±SD 15.74, respectively. The Procedure-related complications were 8.3% for lesion (3/36) and 8.8% for patient (3/34), included 1 acute thrombosis, which obtained complete patency by means of intrathrombus thombolysis at once without sequelae, and 2 ischemic perforator strokes (1 irreversible stroke and 1 reversible). The disable stroke, defined as one that led to mRS score of ≥2, 30 days after the stroke, occurred in one patient ( 2.9%, 1/34; mRS of 2). Procedure success, defined as stent success without disable stroke or death at discharge by means of the endovascular therapy, was achieved in 33 lesions ( 91.7%, 33/36) and in 31 patients ( 91.2%, 31/34). Treatment success, defined as stent success without disable stroke and death at the 30th day, by means of the endovascular and medical therapy, was obtained in 34 lesions ( 94.4%, 34/36) and 32 patients ( 94.1%, 32/34). Clinical Follow-up, median 170 days (ranged from 30 days to 273 days; ≥1 month, n=34; ≥3 months, n=23; ≥6 months, n=13), was performed in 34 patients. There were no ischemic neurological events and death occurred. Cumulated disable stroke occurred in 1 patient ( 2.9%, 1/34). NIHSS was 1.09±SD of 1.694 and 0.47±SD of 1.051, before procedure and at the 30th day (n=34), respectively, and 0.57±SD of 0.992 at 3 months (n=23), 0.15±SD of 0.376 at 6 months (n=13), respectively; mRS was 0.65±SD of 0.812 and 0.47±SD of 0.563, before procedure and at 30 days, respectively, and 0.61±SD of 0.583 at 3 months, 0.38±SD of 0.506 at 6 months, respectively; and BI was 97.54±SD of 5.918 and 99.26±SD of 2.179, before procedure and at 30 days, respectively, and 99.35±SD of 2.288 at 3 months, 100.00±SD | Wei-Jian Jiang, MD Min Jin, MD Bin Du, MD Yong-Jun Wang, MD Xiao-Tong Xu, MD Qing-He Wang, MD Ning Ma, MD Long-Yi Wang, MO Jian-Ping Dai, MD From the Neurovascular Angioplasty Team, Department of Neurology and Neuroradiology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China. Correspondence to Wei-Jian Jiang, MD, Department of Neurology and Neuroradiology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, 100050, China. | 2004 | 介入放射学杂志2004，13，S1： | 2 |
| 16 | Accuracy of Determining Nodal Negativity in Colorectal Cancer on the Basis of the Number of Nodes Retrieved on Resection显示文摘 | Natalie E. Joseph MD Elin R. Sigurdson MD PhD Alexandra L. Hanlon PhD Hao Wang MS Robert J. Mayer MD John S. MacDonald MD Paul J. Catalano ScD Daniel G. Haller MD | 2003 | Annals of Surgical Oncology2003，，3： | 2 |
| 17 | Effect of berber- ine on the differentiation of adipocyte 显示文摘 | ZHOU LB CHEN MD WANG X | 2003 | Zhonghua Yi Xue Za Zhi2003，83，4： | 1 |
| 18 | Molecular basis of genetic variation in debrisoquine hydroxylation in chinese subjects:Polymorphism in RFLP and DNA sequence of CYP2D6显示文摘 | Wang SL Huang JD Lai MD | 1993 | Clin Pharmacol Ther1993，53，： | 1 |
| 19 | Systematic review of the impact of beta blockers on mortality and hospital admission in heart failure 显示文摘 | Shibata MC Flather MD Wang D | 2001 | Eur J Heart Fail2001，3，3： | 1 |
| 20 | Meeting report of the chief editorial board meeting for World Journal of Diabetes 2021显示文摘The 2021 online editorial board meeting of the World Journal of Diabetes(WJD)was held on November 9,2021.Jin-Lei Wang,General Manager on behalf of the Baishideng Publishing Group,and Professor Islam,one of the Editors-in-Chiefs(EiCs)of the WJD,organized the meeting.Three EiCs and 18 Baishideng Publishing Group staff attended the meeting.The meeting goal was to brief the EiCs on the journal’s performance,discuss the issues of concern of the EiCs,and gather ideas for the journal’s development in 2022.As of November 8,the WJD had received 287 manuscripts since the year’s start,among which 122 met the criteria for publication.These numbers represent an increase of 117.4%for submissions and 110.3%for publications compared to those in 2020.However,how to effectively control the academic quality of manuscripts and attract highquality original article submissions remain a challenge.The EiCs provided feedback and suggestions centered on three topics:(1)Who should and how to control the academic quality of the manuscripts;(2)How the EiCs perform their responsibilities;and(3)The distinctive and shared responsibilities of the publisher and the EiCs. | Jin-Lei Wang Jia-Ping Yan Xiang Li Md Shahidul Islam Jian-Bo Xiao Lu Cai Na Ma Li Ma Lian-Sheng Ma | 2021 | World Journal of Diabetes2021，12，12： | 1 |
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