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| 1 | MiR-146a-5p targeting SMAD4 and TRAF6 inhibits adipogenensis through TGF-β and AKT/mTORC1 signal pathways in porcine intramuscular preadipocytes显示文摘Background: Intramuscular fat(IMF) content is a vital parameter for assessing pork quality. Increasing evidence has shown that microRNAs(miRNAs) play an important role in regulating porcine IMF deposition. Here, a novel miRNA implicated in porcine IMF adipogenesis was found, and its effect and regulatory mechanism were further explored with respect to intramuscular preadipocyte proliferation and differentiation.Results: By porcine adipose tissue miRNA sequencing analysis, we found that miR-146a-5p is a potential regulator of porcine IMF adipogenesis. Further studies showed that miR-146a-5p mimics inhibited porcine intramuscular preadipocyte proliferation and differentiation, while the miR-146a-5p inhibitor promoted cell proliferation and adipogenic differentiation. Mechanistically, miR-146a-5p suppressed cell proliferation by directly targeting SMAD family member 4(SMAD4) to attenuate TGF-β signaling. Moreover, miR-146a-5p inhibited the differentiation of intramuscular preadipocytes by targeting TNF receptor-associated factor 6(TRAF6) to weaken the AKT/mTORC1 signaling downstream of the TRAF6 pathway.Conclusions: MiR-146a-5p targets SMAD4 and TRAF6 to inhibit porcine intramuscular adipogenesis by attenuating TGF-β and AKT/mTORC1 signaling, respectively. These findings provide a novel miRNA biomarker for regulating intramuscular adipogenesis to promote pork quality. | Que Zhang Rui Cai Guorong Tang Wanrong Zhang Weijun Pang | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 10 |
| 2 | Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation显示文摘Radiotherapy is one of the most effective treatment methods for various solid tumors.Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness.Exosomes,initially considered as'garbage bins'for unwanted from cells,are now understood to perform a variety of functions in interactions within the tumor microenvironment.Exosome-mediated regulation processes are rebuilt under the irradiation stimuli,because the exosome production,uptake,and contents are markedly modified by irradiation.In turn,irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation.Here,we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions. | Chuanshi He Ling Li Linlin Wang Wanrong Meng Yaying Hao Guiquan Zhu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | Removing and recycling mercury from scrubbing solution produced in wet nonferrous metal smelting flue gas purification process显示文摘Wet purification technology for nonferrous metal smelting flue gas is important for mercury removal;however, this technology produces a large amounts of spent scrubbing solution that contain mercury. The mercury in these scrubbing solutions pose a great threat to the environment. Therefore, this research provides a novel strategy for removing and recycling mercury from the scrubbing solution, which is significant for decreasing mercury pollution while also allowing for the safe disposal of wastewater and a stable supply of mercury resources. Some critical parameters for the electrochemical reduction of mercury were studied in detail. Additionally, the electrodeposition dynamics and electroreduction mechanism for mercury were evaluated. Results suggested that over 92.4% of mercury could be removed from the scrubbing solution in the form of a Hg-Cu alloy under optimal conditions within 150 min and with a current efficiency of approximately 75%. Additionally, mercury electrodeposition was a quasi-reversible process, and the controlled step was the mass transport of the reactant. A pre-conversion step from Hg(Tu)_(4)^(2+) to Hg(Tu)_(3)^(2+) before mercury electroreduction was necessary. Then, the formed Hg(Tu)_(3)^(2+) on the cathode surface gained electrons step by step. After electrodeposition, the mercury in the spent cathode could be recycled by thermal desorption. The results of the electrochemical reduction of mercury and subsequent recycling provides a practical and easy-to-adopt alternative for recycling mercury resources and decreasing mercury contamination. | Shu Yang Ziliang Li Kang Yan Xi Zhang Zhifeng Xu Wanrong Liu Zhilou Liu Hui Liu | 2021 | Journal of Environmental Sciences2021，33，5： | 2 |
| 4 | Noninvasive assessment of renal fractional flow reserve: are we there yet?显示文摘 | QiXiaolong Fan Guoxin Li Zhiwei Ma Wanrong Yang Changqing | 2014 | Chinese Medical Journal2014，，5： | 2 |
| 5 | An Efficient Broadcast Authentication Protocol in Wireless Sensor Networks显示文摘 | ZHAO Xin WANG Xiaodong YU Wanrong ZHOU Xingming | 2009 | Chinese Journal of Electronics2009，18，2： | 2 |
| 6 | MS-Stability of the Euler-Maruyama Method for Stochastic Differential Delay Equations显示文摘 | CAO Wanrong LIU Mingzhu FAN Zhencheng | 2004 | Applied Mathematics and Computation2004，159，： | 1 |
| 7 | Pretreatment study on chloridizing segregation and magnetic separation of low-grade nickel laterites显示文摘 | LIU Wanrong LI Xinhai HU Qiyang | 2010 | Transactions of Nonferrous Metals Society of China2010，20，1： | 1 |
| 8 | The feedback technology for etc,the flatness and stability of UWB LNA显示文摘 | Donghui Zhang Wanrong Zhang Dongyue Jin etc | 2011 | IEEE2011，，： | 1 |
| 9 | Hybrid C8-BTBT/In GaAs nanowire heterojunction for artificial photosynaptic transistors显示文摘The emergence of light-tunable synaptic transistors provides opportunities to break through the von Neumann bottleneck and enable neuromorphic computing.Herein,a multifunctional synaptic transistor is constructed by using 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene(C8-BTBT)and indium gallium arsenide(InGaAs)nanowires(NWs)hybrid heterojunction thin film as the active layer.Under illumination,the Type-I C8-BTBT/InGaAs NWs heterojunction would make the dissociated photogenerated excitons more difficult to recombine.The persistent photoconductivity caused by charge trapping can then be used to mimic photosynaptic behaviors,including excitatory postsynaptic current,long/short-term memory and Pavlovian learning.Furthermore,a high classification accuracy of 89.72%can be achieved through the single-layer-perceptron hardware-based neural network built from C8-BTBT/InGaAs NWs synaptic transistors.Thus,this work could provide new insights into the fabrication of high-performance optoelectronic synaptic devices. | Yiling Nie Pengshan Xie Xu Chen Chenxing Jin Wanrong Liu Xiaofang Shi Yunchao Xu Yongyi Peng Johnny C.Ho Jia Sun Junliang Yang | 2022 | Journal of Semiconductors2022，43，11： | 1 |
| 10 | Convergence and stability of the semi-implicit Euler method for a linear stochastic differential delay equation 显示文摘 | Liu Mingzhu Cao Wanrong Fan Zhencheng | 2004 | Journal of Computational and Applied Mathematics2004，170，： | 1 |
| 11 | Layer-by-layer slot-die coated high-efficiency organic solar cells processed using twin boiling point solvents under ambient condition显示文摘Layer-by-layer (LbL) strategy has been developed to form bulk heterojunction (BHJ) structure for processing efficient organic solar cells (OSCs). Herein, LbL slot-die coating with twin boiling point solvents (TBPS) strategy was developed to fabricate highly efficient OSCs, which matches with large-scale, high throughput roll-to-roll (R2R) industrialized mass process. The TBPS strategy could produce high-quality thin film without any additive, leading to the optimized vertical phase separation with interpenetrating nanostructures, as well as the enhanced charge transport and extraction. Thus, the power conversion efficiency up to 14.42% was achieved for [(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo [1,2-b:4,5-b′]dithiophene))-alt-(5,5-(1′,3′-di-2-thienyl-5′,7′-bis(2-ethylhexyl)benzo[1′,2′-c:4′,5′-c′]dithiophene-4,8-dione)]:2,2′-((2Z,2′Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3″:4″,5″]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene)) bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (PM6:Y6) OSCs fabricated via sequentially LbL slot-die coating using the TBPS strategy under ambient condition. The research provides a potential route for industrialized production of high-efficiency and large-area OSC devices. | Yu Yang Erming Feng Hengyue Li Zichao Shen Wanrong Liu Jingbo Guo Qun Luo Jidong Zhang Guanghao Lu Changqi Ma Junliang Yang | 2021 | Nano Research2021，14，11： | 1 |
| 12 | MS-stability of the Euler-Maruyama method for stochastic differential dalay equations显示文摘 | Cao Wanrong Liu Mingzhu Fan Zhencheng | 2004 | Appl Math Comput2004，159，： | 1 |
| 13 | MS-stability of the Euler-Maruyama method for stochastic differential delay equations显示文摘 | Cao Wanrong Liu Mingzhu Fan Zhencheng | 2004 | Applied Mathematics and Computation2004，159，： | 1 |
| 14 | T-stability of the semi-implicit Euler method for delay differential equations with multiplicative noise显示文摘 | Cao Wanrong | 2010 | Appl Math Comput2010，216，： | 1 |
| 15 | Convergence and stability of the semi-implicit Euler method for a linear stochastic differential delay equation显示文摘 | Liu Mingzhu Cao Wanrong Fan Zhencheng | 2004 | J Comput Appl Math2004，170，： | 1 |
| 16 | The Introduction of XML Language显示文摘 | Yu Wanrong | 2002 | Programmer2002，，5： | 1 |
| 17 | Convergence and stability of the semi implicit Euler method for a linear stochastic differential delay equation显示文摘 | Liu Mingzhu Cao Wanrong Fan Zhencheng | 2004 | Journal of Computational and Applied Mathematics2004，170，2： | 1 |
| 18 | MS-stability of the Euler-Maruyama method for stochas- tic differential delay equations显示文摘 | CAO Wanrong LIU Mingzhu FAN Zhencheng | 2004 | Applied Mathematics and Computation2004，159，： | 1 |
| 19 | Existence and Uniqueness of the Solutions and Convergence ofSemi-implicit Euler Methods for Stochastic Pantograph Equations 显示文摘 | FAN Zhencheng LIU Mingzhu CAO Wanrong | 2007 | J Math Anal Appl2007，325，2： | 1 |
| 20 | MS-stability of the Euler-Maruyama method for stochastic differential delay equations显示文摘 | Wanrong Cao Mingzhu Liu Zhencheng Fan | 2004 | Applied Mathematics and Computation2004，159，： | 1 |
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