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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Synthesis and structure of a copper sulfate/kinked organo di- imine coordination显示文摘 | Warren R Knapp Ronald M Supkowski Robert L LaDuca | 2008 | Inorg Chem Commun2008，11，10： | 1 |
| 3 | Comprehensive numerical modeling of vertical cavity surfaceemitting lasers显示文摘 | HADLEY G R LEAR K L WARREN M E | 1996 | IEEE J Quant Electron1996，32，4： | 1 |
| 4 | Glycosynthases: mutant glycosidases for oligosaccharide synthesis 显示文摘 | Mackenzie L F Wang Q Warren R A J | 1998 | Journal of the American Chemical Society1998，120，22： | 1 |
| 5 | Solar Water Splitting Cells显示文摘 | Walter M G Warren E L McKone J R | 2010 | Chemical Reviews2010，110，11： | 1 |
| 6 | Distribution and chemistry ofdiagenetic minerals at Yucca mountain,Nye county,Nevada显示文摘 | Broxton D E Btsh D L Warren R G | 1987 | Clays and Clay Minerals1987，35，2： | 1 |
| 7 | Do Children 'D/R-M' Like Adults? False Memory Production in Children显示文摘 | Metzger R L Warren A R Price I D | 2008 | Developmental Psychology2008，44，： | 1 |
| 8 | J Am Chem Soc显示文摘 | Mackenzie L Wang Q Warren R A | 1998 | 1998,120: 5583-55841998，120，： | 1 |
| 9 | Modeling and simulating of mobile satellite propagation显示文摘 | BARTS Michael R STUTZMAN Warren L | 1992 | IEEE Trans on Antennas Propagat1992，40，4： | 1 |
| 10 | Theory of electron-avalanche breakdown in solids显示文摘 | SPARKS M MILLS D L WARREN R | 1981 | Phys Rev B1981，24，6： | 1 |
| 11 | Simulations of the penetration of 6061 - T6511 aluminum targets by spherical-nosed VAR4340 steel projec- tiles 显示文摘 | Warren T L Tabbara M R | 2000 | International Journal of Solids and Structures2000，37，44： | 1 |
| 12 | A Process Analysis of Global Trade Management:An Inductive Approach显示文摘 | Hausman Warren H Lee Hau L Napier Graham R F | | 0，，02： | 1 |
| 13 | Correlation between photoluminescence and oxygen vacancies in ZnO phosphors 显示文摘 | VANHEUSDEN K SEAGER C H WARREN W L TALLANT D R VOIGT J A | 1996 | Applied Physics Letters1996，68，： | 1 |
| 14 | Kinetics of the reaction of H(^2S) with HBr显示文摘 | TALUKDAR R K WARREN R F VAGHIJIANI G L | 1992 | Int J Chem Kinet1992，，24： | 1 |
| 15 | Projecting monthly natural gas sales for space heating using a monthly updated model and degree-days from monthly outlooks显示文摘 | Lehman R L Warren H E | 1994 | Jour- nal of Applied Meteorology1994，33，1： | 1 |
| 16 | Control and biochemical nature of the ecdysteroidogenic pathway显示文摘 | Gilbert L I Rybczynski R Warren J T | 2002 | Annu Rev Entomol2002，47，： | 1 |
| 17 | A test for linkage and association in general pedigrees:the pedigree disequilibrium test显示文摘 | Martin E R Monks S A Warren L L | 2000 | Am J Hum Genet2000，67，： | 1 |
| 18 | Assembling millions of short DNA sequences using SSAKE显示文摘 | WARREN R L SUTTON G G JONES S J M | 2007 | Bioinformatics2007，23，4： | 1 |
| 19 | The acute metabolic effects of tumor necrosis factor administration in humans显示文摘 | WARREN R S STARNES H F Jr GABRILOVE J L | 1987 | Arch Surg1987，122，12： | 1 |
| 20 | Increased photosynthesis following partial defoliation of field-grown Eucalyptus globulus seedlings is not caused by increased leaf nitrogen显示文摘 | TURMBULL T L ADAMS M A WARREN C R | 2007 | Tree Physiology2007，27，： | 1 |
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