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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | An examina- tion of the mediating role of psychological empower- ment on the relations between the job,interpersonal relationships,and work outcomes显示文摘 | Liden R C Wayne S Sparrowe R T | 2000 | Journal of Ap- plied Psychology2000，85，3： | 1 |
| 3 | Serum Uric Acid and Risk of Coronary Heart Disease显示文摘 | Joseph T Moriarity Aaron R Folsom Carlos Iribarren F.Javier Nieto Wayne D Rosamond | 2000 | Annals of Epidemiology2000，，3： | 1 |
| 4 | Leader-mem- ber exchange theory: The past and potential for the future显示文摘 | Liden R C Sparrowe R T Wayne S J | 1997 | Research in Personnel and Human Resource Management1997，15，1： | 1 |
| 5 | An exami-nation of the mediating role of psychological em powerment on the relations between the job, in terpersonal relationships, and work outcome显示文摘 | Liden R C Wayne S J Sparrowe R T | 2000 | Journal of Applied Psychology2000，85，40： | 1 |
| 6 | A Comparison of linear and daily undulating per--iodized programs with equated volume and intensity for loealmuscular enduranee显示文摘 | MATFHEW R RHEA WAYNE T PHILLIPS LEE N BUR-KETT | 2003 | J Strength Condition Res2003，17，1： | 1 |
| 7 | Social networks and the performance of individuals and groups 显示文摘 | Sparrowe R T Liden R C Wayne S J | 2001 | Academy of Management Journal2001，44，2： | 1 |
| 8 | An examination of the mediating role of psychological empowerment on the rel- ations between the job, interpersonal relations, and work outcomes显示文摘 | Liden R C Wayne S J Sparrowe R T | 2000 | Journal of Applied Psychology2000，85，： | 1 |
| 9 | Social networks and the performance of individuals and groups 显示文摘 | SPARROWE R T LIDEN R C WAYNE S J | 2001 | Academy of Management Journal2001，，44： | 1 |
| 10 | An examination of the mediating role of psychological empowerment on the re lations between the job, interpersonal relationships, and work outcome显示文摘 | LidenR C Wayne S J Sparrowe R T | 2000 | J Appl Psychol2000，85，3： | 1 |
| 11 | Social Networks and thePerformance of Individuals and Groups显示文摘 | Sparmwe R T Liden R C Wayne S J | 2001 | Academy of ManagementJournal2001，44，2： | 1 |
| 12 | Evolution of heterochromatin-associated satellite DNA loci in felids and canids (Carnivora)显示文摘 | Modi W S Wayne R K | 1988 | Cytogenet Cell Genet1988，48，4： | 1 |
| 13 | Leader-member exchange theory: the past and potential for the future 显示文摘 | LIDEN R C SPARROWE R T WAYNE S J | 1997 | Research in Personnel and Human Resource Management1997，，15： | 1 |
| 14 | Speciation and Rapid Phenotypic Differentiation in the Yellow-rumped Warbler Den- droica coronata Complex 显示文摘 | MILA B O SMITH T H WAYNE R O | 2007 | Molecular Ecology2007，16，1： | 1 |
| 15 | An examination of the mediating role of psychological empowerment on the relations between the job, interpersonal relationships, and work outcomes显示文摘 | Liden R C Wayne S J and Sparrowe R T | 2000 | Journal of Applied Psychology2000，85，3： | 1 |
| 16 | Combining SSH and Cdna microarrays for rapid identification of differen- tially expressed genes 显示文摘 | George P Y Douglas T R Wayne W K | 1999 | Nucleic Acids Research1999，27，： | 1 |
| 17 | Social networks and the performance of individuals and groups 显示文摘 | SPARROWE R T LIDEN R C WAYNE S J et at | 2001 | Academy of manage- ment journal2001，44，2： | 1 |
| 18 | An examination of the mediating role of psychological empowerment on the rela- tions between the job, interpersonal relationships, and work out- come 显示文摘 | Liden R C Wayne S J Sparrowe R T | 2000 | Journal of Applied Psychology2000，85，3： | 1 |
| 19 | An examination of the mediating role of psychological empowerment on the rela- tions between the job, interpersonal Relationships, and work outcomes 显示文摘 | Liden R C Wayne S J Sparrowe R T | 2000 | Journal of Applied Psychology2000，85，3： | 1 |
| 20 | Social networks and the performance of individuals and groups 显示文摘 | Span'owe R T Liden R C Wayne S J Kraimer M L | 2001 | The Academy of Management Jour- nal2001，44，2： | 1 |
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