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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Correction of flux measurements for density effects due to heat and water va- pour transfer显示文摘 | Webb E K Pearman G I Leuning R | 1980 | Quarterly Journal of the Royal Meteorological Society1980，106，447： | 1 |
| 3 | Tree-in-bud pattern: frequency and significance on thin section CT显示文摘 | Aquino S L Gamsu G Webb W R | 1996 | J Comput Assist Tomogr1996，20，4： | 1 |
| 4 | Correction of flux measurements for density effects due to heat and water vapor transfer显示文摘 | Webb E K G I Pearman R Leuning | 1980 | Quart J Roy Meteor Soc1980，106，： | 1 |
| 5 | Percutaneous aortic valve implantation retrograde from the femoral artery显示文摘 | Webb J G Chandavimol M Thompson C R Ricci D R Carere R G Munt B I | 2006 | Circulation2006，113，： | 1 |
| 6 | Stenting for coronary artery spasm显示文摘 | Khatri S Webb J G Carere R G | 2002 | Catheter Cardiovasc Interv2002，56，1： | 1 |
| 7 | Frequency and initiation of debris flows in Grand Canyon, Arizona 显示文摘 | Griffiths P G Webb R H Melis T S | 2004 | Journal of Geophysical Research2004，，109： | 1 |
| 8 | CT in Carcinoma of the larynx and pyriform sinus: value of phonation scans AJR 显示文摘 | Gamsu G Webb W R Shalht J B | 1981 | 136(3):577-5841981，136，3： | 1 |
| 9 | Application of rough surfaces to heat exchanger design显示文摘 | WEBB R L ECKERT E R G | 1972 | Int J Heat Mass Transfer1972，15，9： | 1 |
| 10 | Correction of flux measurement for density effects due to heat and water vapour transfer显示文摘 | Pearman G I Leuning R | 1980 | Quarterly Journal Royal Meteorological Society1980，106，： | 1 |
| 11 | Correction of flux measurements for density effects due to heat and water vapour transfer 显示文摘 | Webb E K Pearman G I Leuning R | 1980 | Quarterly Journal of the Royal Meteorological Society1980，106，： | 1 |
| 12 | Application of rough surfaces to heat exchanger design显示文摘 | WEBB R L ECKERT E R G | 1972 | International Journal of Heat and Mass Transfer1972，15，9： | 1 |
| 13 | Learning by extrapo-lation from marginal to full-multivariate probability distributions:decreasingly naive Bayesian classification显示文摘 | Webb G I Boughton J R Zheng Fei | 2012 | Machine Learning2012，86，2： | 1 |
| 14 | Correction of flux measure ments for density effects due to heat and water vapour transfer显示文摘 | WEBB E K PEARMAN G I LEUNING R | 1980 | Quarterly Journal of the Royal Meteorological Society1980，106，： | 1 |
| 15 | Correction of flux measurements for density effects due to heat and water vapour transfer 显示文摘 | Webb E K Pearman G I Leuning R | 1980 | Quarterly Journal of the Royal Meteorological Society1980，106，447： | 1 |
| 16 | Correction of flux measurements for density effects due to heat and water vapor transfer显示文摘 | Webb E K G I Pearman R Leuning | 1980 | Quart J Roy Meteor Soc1980，106，： | 1 |
| 17 | Percutaneous aortic valve implantation retrograde from the femoral artery显示文摘 | WEBB J G CHANDVIRNOL M THOMPSON C R | 2006 | Circulation2006，113，： | 1 |
| 18 | Application of rough surfaces to heat exchanger design显示文摘 | Webb R L Eckert E R G | 1972 | International Journal of Heat Mass Transfer1972，15，9： | 1 |
| 19 | Three point boundary value problems with solutions that change sign显示文摘 | Infante G Webb J R L | 2003 | J Integral Equations Appl2003，15，1： | 1 |
| 20 | Nonzero solutions of Hammerstein integral equations with discontinuous kernels显示文摘 | Infante G Webb J R L | 2002 | J Math Anal Appl2002，272，1： | 1 |
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