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| 1 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
| 2 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 3 | Mircroradiographic characterization of metal and polymer coated microspheres显示文摘 | Singleton R M Weir J T | 1981 | J Vac Sci Technol1981，18，3： | 2 |
| 4 | Conditional genotypic probabili ties for microsatellite loci显示文摘 | Curran J Weir B S | 2000 | Genetics2000，155，4： | 1 |
| 5 | C-reactive protein and outcome after ischcmic stroke 显示文摘 | Muir KW Weir C J Alwan W | 1999 | Stroke1999，30，5： | 1 |
| 6 | Prevalence of radiological signs of femoro- aeetabular impingement in patients pres- enting with long-standing adductor-related groin pain显示文摘 | Weir A de Vos R J Moen M | 2011 | Br J Sports Med2011，45，1： | 1 |
| 7 | Annual report to the nation on the status of cancer, 1975 - 2000, featuring the uses of surveillance da- ta for cancer prevention and control 显示文摘 | Weir HK Thun M J Hankey BF | 2003 | Natl Cancer lnst2003，95，17： | 1 |
| 8 | Islet mass and function in diabetes and transplantation显示文摘 | WEIR G C BONNER-WEIR S LEAHY J L | 1990 | Diabetes1990，39，4： | 1 |
| 9 | Oxidative Damage to Nucleic Acids Photosensitized by Titanium Dioxide 显示文摘 | WAMER W G YIN J J WEIR R | 1997 | Free Radic Biol Med1997，23，6： | 1 |
| 10 | C-reactivep rotein and outcome after ischennic stroke 显示文摘 | Muir K W Weir C J Alman W | 1999 | Stroke1999，30，5： | 1 |
| 11 | 显示文摘 | Helen L Gerhard J | 1998 | Chest1998，114，： | 1 |
| 12 | Protective immunity against herpes simplex virus generated by DNA vaccination compared to natural infection 显示文摘 | Nass P H Elkins K L Weir J P | 2001 | Vaccine2001，19，1112： | 1 |
| 13 | Conserved TAAATG sequcence at the transcriptional initiation sitees of vaccinia virus late genes deduced by structural and functional analysis of the HindШ geneome fragment显示文摘 | Rose l L Earl P L Weir J P | 1986 | Virol1986，605，： | 1 |
| 14 | Three-dimensional computer-simulated prostate models: lateral prostate biopsies increase the detection rate of prostate cancer显示文摘 | Bauer J J Zeng J Weir J | 1999 | Urology1999，53，5： | 1 |
| 15 | Associations be- tween meteorological variables and acute stroke hospital admis- sions in the west of Scotland显示文摘 | Dawson J Weir C Wright F Bryden C | 2008 | Acta Neurol Scand2008，117，2： | 1 |
| 16 | β - cell deficit and increased β- cell apoptosis in humans with type 2 diabetes显示文摘 | Butler AE Janson J Bonner - Weir S | 2003 | Diabetes2003，52，1： | 1 |
| 17 | Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke显示文摘 | Weir C J Mair S W Waters M R | 2003 | Stroke2003，34，8： | 1 |
| 18 | Changing trends in incidence and mortality of thyroid cancer in Scotland显示文摘 | Reynolds RM Weir J Stockton DL | 2005 | Clin Endocrinol(Oxf)2005，62，2： | 1 |
| 19 | Diallel analysis for sex-linked and maternal effects显示文摘 | Zhu J Weir B S | 1996 | Theoretical and Applied Genetics1996，92，1： | 1 |
| 20 | Biochemical and physiological mechanisms mediated by allelochemicals显示文摘 | Weir T L Park S W Vivanco J M | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
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