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| 1 | Characterization of cancer stem-like cells in the side population cells of human gastric cancer cell line MKN-45显示文摘Objective:Side population(SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer.Many kinds of cell lines and tissues have demonstrated the presence of SP cells,including several gastric cancer cell lines.This study is aimed to identify the cancer stem-like cells in the SP of gastric cancer cell line MKN-45.Methods:We used fluorescence activated cell sorting(FACS) to sort SP cells in the human gastric carcinoma cell line MKN-45(cells labeled with Hoechst 33342) and then characterized the cancer stem-like properties of SP cells.Results:This study found that the SP cells had higher clone formation efficiency than major population(MP) cells.Five stemness-related gene expression profiles,including OCT-4,SOX-2,NANOG,CD44,and adenosine triphosphate(ATP)-binding cassette transporters gene ABCG2,were tested in SP and MP cells using quantitative real-time reverse transcription polymerase chain reaction(RT-PCR).Western blot was used to show the difference of protein expression between SP and MP cells.Both results show that there was significantly higher protein expression in SP cells than in MP cells.When inoculated into non-obese diabetic/severe combined immunodeficiency(NOD/SCID) mice,SP cells show higher tumorigenesis tendency than MP cells.Conclusions:These results indicate that SP cells possess cancer stem cell properties and prove that SP cells from MKN-45 are gastric cancer stem-like cells. | Hai-hong ZHANG Ai-zhen CA Xue-ming WEI Li DING Feng-zhi LI Ai-ming ZHENG Da-jiang DAI Rong-rong HUANG Hou-jun CAO Hai-yang ZHOU Jian-mei WANG Xue-jing WANG Wei SHI Heng ZHU Xiao-ying YUAN Lin CHEN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 9 |
| 2 | Geological thermal events in Tarim Basin显示文摘TARIM Basin is the biggest sedimentary basin in China, and it is also an important area of | Chen, HL Yang, SF Dong, CW Zhu, GQ Jia, CA Wei, GQ Wang, ZG | 1997 | Chinese Science Bulletin1997，42，7： | 5 |
| 3 | Rate of convergence for the Legendre pseudospectral optimal control of feedback linearizable systems显示文摘Pseudospectral (PS) computational methods for nonlinear constrained optimal control have been applied to many industrial-strength problems,notably,the recent zero-propellant-maneuvering of the international space station performed by NASA.In this paper,we prove a theorem on the rate of convergence for the optimal cost computed using a Legendre PS method.In addition to the high-order convergence rate,two theorems are proved for the existence and convergence of the approximate solutions.Relative to existing work on PS optimal control as well as some other direct computational methods,the proofs do not use necessary conditions of optimal control.Furthermore,we do not make coercivity type of assumptions.As a result,the theory does not require the local uniqueness of optimal solutions.In addition,a restrictive assumption on the cluster points of discrete solutions made in existing convergence theorems is removed. | Wei KANG (Department of Applied Mathematics,Naval Postgraduate School,Monterey CA 93943,USA) | 2010 | 控制理论与应用(英文版)2010，8，4： | 5 |
| 4 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 5 | Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor显示文摘 | Wei LH Kuo ML Chen CA | 2001 | Gynecol Oncol2001，82，1： | 1 |
| 6 | Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway显示文摘 | Wei LH Kuo ML Chen CA | 2003 | Oncogene2003，22，： | 1 |
| 7 | Radical hysterectomy alone or combined with neoadjuvant chemotherapy in the treatment of early stage bulky cervical carcinoma显示文摘 | Chen CA Cheng WF Wei LH | 2002 | J Formos Med Assoc2002，101，3： | 1 |
| 8 | Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction显示文摘 | Wei M Macera CA Davis DR | 1994 | Am J Epidemiol1994，140，10： | 1 |
| 9 | Radical hysterectomy alone or combined with neoadjuvant ehemotherapy in the treatment of early stage bulky cervical carcinoma 显示文摘 | Chen CA Cheng WF Wei LH | 2002 | J Formos Med Assoc2002，101，3： | 1 |
| 10 | Radical hysterectomy alone or combined with neoadjuvant chemotherapy in the treatment of early stage bulky cervical carcinoma 显示文摘 | Chen CA Cheng WF Wei LH | 2002 | J Formos Med Assoc2002，101，3： | 1 |
| 11 | The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/ Akt pathway 显示文摘 | Wei LH Kuo ML Chen CA | 2001 | Oncogene2001，20，41： | 1 |
| 12 | Genetic alterations and oncogenic pathways in hepatocellular carcinoma 显示文摘 | Levy L Renard CA Wei Y | 2002 | Ann N Y Acad Sci2002，963，1： | 1 |
| 13 | Interleukin-6 promotes cervical tumor growth by VEGF dependent angiogenesis via a STAT3 pathway显示文摘 | Wei LH Kuo ML Chen CA | 2003 | Oncogene2003，22，10： | 1 |
| 14 | Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway显示文摘 | Wei LH Kuo ML Chen CA | 2003 | Oncogene2003，22，10： | 1 |
| 15 | Androgen deprivation therapy for prostate cancer results in significant loss of bone density 显示文摘 | Wei JT Gross M Jaffe CA | 1999 | Urology1999，54，4： | 1 |
| 16 | Radical hysterectomy alone or combined with neoadjuvant chemotherapy in the treatment of early stage bulky cervical carcinoma显示文摘 | Chen CA Cheng WF Wei LH | 2002 | J Formos Med Assoc2002，101，： | 1 |
| 17 | Prevalence and treatment of diagnosed depression among elderly nursing home residents in Ohio 显示文摘 | Levin CA Wei W Akincigil A | 2007 | J Am Med Dir Assoc2007，8，9： | 1 |
| 18 | Radical hysterectomy alone or combined with neoadjuvant chemotherapy in the treatment of early stage bulky cervical carcinoma显示文摘 | Chen CA Cheng WF Wei LH | 2002 | J Formos Med Assoc2002，101，3： | 1 |
| 19 | Nuclear accumulation of mutated β-catenin in hepatocellular carcinoma is associated with increased cell proliferation显示文摘 | Nhieu JTV Renard CA Wei Y | 1999 | Am J Pathol1999，155，3： | 1 |
| 20 | Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor 显示文摘 | Wei LH Kuo ML Chen CA | 2001 | Gynecol Oncol2001，82，1： | 1 |
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