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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Perceived symptoms and health-related quality of life reported by uncomplicated hypertensive patients compared to normal controls 显示文摘 | Erickson SR Williams BC Gruppen LD | 2001 | J Human Hypertens2001，15，： | 1 |
| 3 | Beta-adrenergic receptor stimulation modulates iNOS protein levels through p38 and ERK1/2 signaling in human retinal endothelial cells 显示文摘 | Steinle JJ Chin VC Williams KP Panjala SR | 2008 | Exp Eye Rex2008，87，1： | 1 |
| 4 | Effect of fermentable carbohydrates on piglet faecal bacterial communities as revealed by denaturing gradient gel electrophoresis analysis of 16S ribosomal DNA显示文摘 | Konstantinov SR Zhu WY Williams BA | | 0，，2： | 1 |
| 5 | Papillary glioneuronal tumor: a case report and review of the literature 显示文摘 | Williams SR Joos BW Parker JC | 2008 | Ann Clin Lab Sei2008，38，3： | 1 |
| 6 | White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives显示文摘 | Menzies L Williams GB Chamberlain SR | 2008 | Am J Psychiatry2008，165，10： | 1 |
| 7 | Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types 显示文摘 | Urenja KJ Williams SR Gadian DG | 1993 | J Neurosci1993，13，3： | 1 |
| 8 | Proton nuclear magnetic resonance spectroscopy unambiguously identifies diferent neural cell types显示文摘 | Urenjak J Williams SR Gadian DG | 1993 | J Neurosci1993，13，3： | 1 |
| 9 | Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechano- sensitive arteriolar constriction显示文摘 | Flavahan NA Bailey SR William A | 2005 | Am J Physiol Heart Circ Physiol2005，288，2： | 1 |
| 10 | Effects of group exercise on cognitive func- tioning and mood in older women 显示文摘 | Williams P Lord SR | 1997 | Aust N Z J Public Health1997，21，1： | 1 |
| 11 | Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer显示文摘 | Greven KM Williams DW 3rd McGuirt WF Sr | 2001 | Head Neck2001，23，11： | 1 |
| 12 | Bioreductive drugs: from concept to clinic 显示文摘 | Mekeown SR Cowen RL Williams KJ | 2007 | Clin Oncol ( R Coll Radiol)2007，19，： | 1 |
| 13 | Bone marrow disorders:characterization with quantitative MR imaging 显示文摘 | Smith SR Williams CE Davies JM | 1989 | Radiology1989，172，： | 1 |
| 14 | Reconstruction of the Medial Patellofemoral Ligament:Clinical Outcomes and Return to Sports显示文摘 | Lippacher S Dreyhaupt J Williams SR | 2014 | Am J Sports Med2014，42，7： | 1 |
| 15 | The effects of a com- munity exercise program on fracture risk factors in older women显示文摘 | Lord SR Ward JA Williams P | 1996 | Osteoporos Int1996，6，5： | 1 |
| 16 | Formic acid skin burns resulting in systemic toxicity显示文摘 | Chan TC William SR Clark RF | | 0，，03： | 1 |
| 17 | Warmup Angina:harnessing the benefits of exercise and myocardial ischaemia显示文摘 | Williams RP Manou-Stathopoulou V Redwood SR | 2014 | Heart2014，100，2： | 1 |
| 18 | Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young,American Heart Association 显示文摘 | Williams CL Hayman LL Daniels SR | 2002 | Circulation2002，106，1： | 1 |
| 19 | Comparison of reliability and responsiveness of patient-reported elinieal outcome measures in knee osteoarthritis rehabilitation显示文摘 | Williams V J Piva SR Irrgang JJ et o2 | 2012 | J Orthop Sports Phys Ther2012，42，8： | 1 |
| 20 | Use of continuous glucose monitor-ing in young children with type 1 diabetes : implications for behavioralresearch显示文摘 | Patton SR Williams LB Eder SJ | 2011 | Pediatr Diabetes2011，12，1： | 1 |
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