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876篇 您的检索式:作者名="Williams H P"
    题名 作者 年代 出处 被引量
1Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan 2013Translational Neurodegeneration2013,2,1:4
2Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong 2003Journal of Gastrointestinal Surgery2003,,3:2
3Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus 2010The Lancet2010,,9739:2
4An artificial immune system architecture for computer security applications 显示文摘HARMER P K WILLIAMS P D GUNSCH G H 2002IEEE Transacctions on Evolutionary Computation2002,6,3:1
5EPA,but not DHA,decreases mean platelet volume in normal subjects显示文摘 WILLIAM H 2002Lipid2002,10,:1
6Evolving gene frequencies in a population with three possible alleles at a loeus显示文摘Bradshaw-Hajek B H Broadbridge P Williams G H 2008Mathematical and Computer Modelling2008,47,:1
7A High Precision Direct Integration Scheme for Structures Subjected to Transient Dynamic Loading显示文摘Lin J H Shen W P Williams F W 1995Computers and Structures1995,56,1:1
8New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica显示文摘Williams P G Buchanan G O Feling R H 2005J Org Chem2005,70,16:1
9A High Precise Direct Integration Scheme for Structures Subjected to Transient Dynamic Loading显示文摘LIN J H SHEN W P WILLIAMS F W 1995Computer & Structures1995,56,2:1
10Engineering salt - tolerant Brassiea plants: Characterization of yield and seed oil quality in transgenie plants with increased vacuolar sodium accumulation 显示文摘Zhang H X Hodson J N Williams J P 2001PNAS2001,98,12:1
11Predictors and patterns of recurrence after resection of hepatocellular carcinoma显示文摘Charles Cha Yuman Fong William R Jarnagin Leslie H Blumgart Ronald P DeMatteo 2003Journal of the American College of Surgeons2003,,5:1
12Researchers' e-journal use and information seeking behavior显示文摘Nicholas D Williams P Rowlands I Jamali H R 2010Journal of Information Science2010,,36:1
13Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease 显示文摘Ichikawa H T Williams L P Segal B M 2002J Immunol2002,169,5:1
14显示文摘 Chishti H M 2001Fuel2001,80,7:1
15New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica 显示文摘Williams P G Buchanan G O Feling R H 2005J Org Chem2005,70,16:1
16Enzyme-inked immunosorbent assay employing monoctonal antibody specific for deoxynivalenol ( Vomitoxin ) and several analogues显示文摘William L C James J P Patrick H L 1988J Agric food ehem1988,36,:1
17Wireless Local Area Network Flight Demonstration for High Doppler Conditions 显示文摘William P Mark H 2004Johns Hopkins APL Technical Digest2004,4,25:1
18Chemical anal-ysis of contaminated soil strengthened by the addition of lime显示文摘Mckinley J D Thomas H R Williams K P 2001Engineering Geology2001,60,:1
19RFLP mapping of Brassica napus using F1-derived doubled haploid lines显示文摘Ferreira M E Williams P H Osborn T C 1994Theor Appl Genet1994,89,:1
20Temperature dependence of Verdet comstant in several diamagnec glasses显示文摘Williams P A Rose A H Day G W 1991Applied Optics1991,30,10:1
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