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| 1 | 局部缓释IUdR治疗恶性星形细胞瘤实验研究(英文)显示文摘目的研究脑局部缓释125碘标记的5-碘脱氧尿苷(IUdR)的作用。方法为了控制释放125碘-IUdR,合成了25μCi的羧基苯氧丙烷:癸二酸(PCPPSA)(2080)125碘-IUdR聚合体。体外将合成的三聚体缓释剂(10mgPCPPSA)置于37℃磷酸盐缓冲溶液(PBS)中孵育不同时间后移出溶剂并置换为新的PBS,将移出液于放射计数器上测量数值。在体研究采用雄性裸鼠(6周)颅内接种U251人恶性星形细胞瘤及皮下接种对比研究。将颅内荷瘤鼠瘤腔内及皮下接种肿瘤组织内分别应用三聚体缓释剂及空白缓释剂,于不同时间分别测量动物头颅及皮下结节的放射活性,间接定量研究缓释状况;采血了解全身代谢情况。对于多聚磷酸酯(PPE)缓释剂研究采用皮下肿瘤结节内局部应用并测量其缓释的方法,放射自显影研究及全身不同器官缓释剂的吸收代谢研究采用接种后2、4和8d收集标本,分别行切片放射自显影和器官放射活性测定。结果体内和体外研究均显示PCPP:SA缓释剂对125碘-IUdR的控制性释放作用,尤其在体研究分别显示颅内和皮下接种的肿瘤组织对标记的IUdR的释放程度存有极大的差异,提示颅内局部应用的优越性。放射自显影定性研究显示了随距离的增加被标记的IUdR的递减趋势,为确定缓释剂施放部位和间距提供了参考数据。各主要脏器放射性测定的结果显示早期小肠内放射性较高,其次为脾脏,提示IUdR主要的代谢渠道,为处理应用其而可能引发的其他脏器损害或作用提供了线索。结论放射标记的IUdR缓释剂主要集中在接种部位且缓释作用确切。 | 马晓东 Jerry R.Williams Larry E.Dillehay Jeffery A Williams | 2005 | 中华神经外科疾病研究杂志2005，4，4： | 3 |
| 2 | Productive and parasitic pathways in dilute acid catalyzed hydrolysis of cellu-lose显示文摘 | Mok William Shu Lai Antal Michael Jerry | 1992 | Ind Eng Chem Res1992，31，1： | 1 |
| 3 | Kriging update model and recursive space-time function estimation显示文摘 | Kerwin William S Prince Jerry L | 1999 | Institute of Electrical and Electronics Engineers Inc Piscataway NJ USA1999，，： | 1 |
| 4 | Accelerated Osteogenic Orthodontics Technique: A 1-Stage Surgically Facilitated Rapid Orthodontic Technique With Alveolar Augmentation显示文摘 | M. Thomas Wilcko William M. Wilcko Jeffrey J. Pulver Nabil F. Bissada Jerry E. Bouquot | 2009 | Journal of Oral and Maxillofacial Surgery2009，，10： | 1 |
| 5 | New RAMS cloud microphysics parameterization. Part II: The two-moment scheme显示文摘 | Michael P. Meyers Robert L. Walko Jerry Y. Harrington William R. Cotton | 1997 | Atmospheric Research1997，，1： | 1 |
| 6 | The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1显示文摘 | Paul G. Thomas Pradyot Dash Jerry R. Aldridge Ali H. Ellebedy Cory Reynolds Amy J. Funk William J. Martin Mohamed Lamkanfi Richard J. Webby Kelli L. Boyd Peter C. Doherty Thirumala-Devi Kanneganti | 2009 | Immunity2009，，4： | 1 |
| 7 | Mechanism of formation of 2-furaldehyde from D-xylose显示文摘 | Michael Jerry Jr Antal Leesomboon Tongchit Mok William S | 1991 | Carbohydrate Research1991，217，： | 1 |
| 8 | Development and evaluation of the Maintenance Error Decision Aid process 显示文摘 | William Rankin Rebecca Hibit Jerry Allen and Robert Sar- gent | 2000 | Intemational Journal of Industrial Ergonomics2000，26，2： | 1 |
| 9 | Alkaloids from Cephalotaxus drupacea and Cephalotaxus fortunei显示文摘 | William W Gerald I Jerry McKay | 1963 | J Org Che1963，28，9： | 1 |
| 10 | Role of antioxidants and trace elements in health and immunity of transition dairy cows显示文摘 | Jerry W William P W | 2008 | The Veterinary Journal2008，176，1： | 1 |
| 11 | Effects on Carbon Storage of Conversion of Old-growth Forests to Young Forests显示文摘 | William K Ferrell Jerry F Franklin | 1990 | Science1990，247，4943： | 1 |
| 12 | Productive and parasitic pathways in dilute acid-catalyzed hydrolysis of cellulose显示文摘 | Shu-Lai Mok William Antal Jr Michael Jerry | 1992 | Ind Eng Chem Res1992，31，1： | 1 |
| 13 | Evaluation of ballistically induced damage in ceramic targets by X-ray computed tomography显示文摘 | WILLIAM H G HERBERT T M JERRY C L | 2008 | Ceramic Engineering & Science Proceedings2008，29，6： | 1 |
| 14 | Cardiac motion tracking using CINE harmonic phase (HARP) magnetic resonance imaging显示文摘 | Nael F.Osman William S.Kerwin Elliot R.McVeigh Jerry L.Prince | 1999 | Magn. Reson. Med1999，，： | 1 |
| 15 | Mechanism of formation of 2-fluraldehyde from D-xylose显示文摘 | Michael Jerry Antal Jr Tongchit Leesomboon William S Mok | 1991 | Carbo- hydrate Research1991，217，18： | 1 |
| 16 | Telecommunication in the US: From Regulation to Competition (Almost)显示文摘 | Jerry A. Hausman William E. Taylor | 2013 | Review of Industrial Organization2013，，2： | 1 |
| 17 | Mineralogical and engineering characteristics of dry flue gas desulfurization products显示文摘 | Jerry M. Bigham David A. Kost Richard C. Stehouwer Joel H. Beeghly Randy Fowler Samuel J. Traina William E. Wolfe Warren A. Dick | 2005 | Fuel2005，，14： | 1 |
| 18 | Microbial degradation of imazaquin and imazethapyr 显示文摘 | JERRY L WILLIAM W W | 1997 | Weed Science1997，45，： | 1 |
| 19 | Long-Term Nitrogen Additions and Nitrogen Saturation in Two Temperate Forests显示文摘 | Alison H. Magill John D. Aber Glenn M. Berntson William H. McDowell Knute J. Nadelhoffer Jerry M. Melillo Paul Steudler | 2000 | Ecosystems2000，，3： | 1 |
| 20 | Patient Genotypes Impact Survival After Surgery for Isolated Congenital Heart Disease显示文摘 | Daniel Seung Kim Jerry H. Kim Amber A. Burt David R. Crosslin Nancy Burnham Donna M. McDonald-McGinn Elaine H. Zackai Susan C. Nicolson Thomas L. Spray Ian B. Stanaway Deborah A. Nickerson Mark W. Russell Hakon Hakonarson J. William Gaynor Gail P. Jarvik | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
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