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| 1 | The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease显示文摘 | Marno C. Ryan Catherine Itsiopoulos Tania Thodis Glenn Ward Nicholas Trost Sophie Hofferberth Kerin O’Dea Paul V. Desmond Nathan A. Johnson Andrew M. Wilson | 2013 | Journal of Hepatology2013，，1： | 6 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | An equilibrium theory of insular zoogeography显示文摘 | MacArthur R H Wilson E O | 1963 | Evolution1963，179，4： | 2 |
| 4 | 中国等蝎属一新种(蝎目,钳蝎科)(英文)显示文摘描述了采于中国西藏等蝎属1新种——西藏等蝎,Isometrus(Reddyanus) tibetanus sp.nov.。为了比较,根据原始模式标本和保存在法国自然博物馆的系列标本,重新描述了原始描述于印度和尚分布于尼泊尔的阿萨姆等蝎Isometrus(Reddyanus) assamensis Oates,1888。西藏等蝎,新种Isometrus(Reddyanus) tibetanus sp.nov.(图1~13,27~31,33)正模♂,中国西藏车苏(Chesu),1970年9月,Lingberg采(现保存在河北大学博物馆)。体长42·70mm。根据一般形态,新种近似于原始描述产于印度和尚分布于尼泊尔的阿萨姆等蝎Isometrus(Reddyanus) assamensis Oates,1888(图14~26,32,33),但如下特征不同于后者:1)身体颜色更浅,呈浅黄色到浅红黄色,具不明显或荒废的斑点,而阿萨姆等蝎I.(R.)assamensis相反,其身体和附肢具褐色斑点,且背甲和中体背板主要为浅褐色,2)后体节的脊和背脊的后顶颗粒较弱,3)背甲和中体背板的颗粒稀少或荒废。词源:新种的种名以模式标本的产地而拟定。 | Wilson R.LOURENO 朱明生 | 2008 | 动物分类学报2008，33，2： | 2 |
| 5 | Physical activity and nutrition attitudes in obese Hispanic children with non-alcoholic steatohepatitis显示文摘AIM:To assess nutrition,physical activity and health-ful knowledge in obese children with biopsy-proven nonalcoholic steatohepatitis(NASH or NA)compared to children without liver disease.METHODS:Children with biopsy-proven NASH comprised the NASH group.Age,sex and ethnicity matched control groups consisted of obese(OB)and lean(CO) children with no liver disease.Subjects were adminis-tered the School Physical Activity and Nutrition Survey and one blood draw was obtained.RESULTS:Fifty-seven patients were enrolled with a mean age of 12.1±2.1 years,and all were Hispanic.Even though the OB and NA had a similar increased body mass index(%),35%of the NA group always read nutrition labels compared to none in the OB(P<0.05),and more NA children felt their diet is'less healthy'.NA consumed the least amount of fruits with only 25%having≥1 fruit/d vs 45%in OB and 64.7% in CO(P<0.05 NA vs CO).Only 15%of NA subjects performed light exercise vs 35%and 59%of OB and CO groups,respectively(P=0.02).The mean physical activity score was lowest in the NA group(P<0.05).Amongst the subjects with NASH,we found that 100% of patients with grade 2 or 3 fibrosis had a sedentary score>2 compared to only 63.6%of those with grade 1 or no fibrosis(P<0.05).CONCLUSION:Children with NASH had increased sedentary behavior,decreased activity,and fruit intake.Larger studies may determine the benefit of changing these behaviors as treatment for NASH. | Lana N Hattar Theresa A Wilson Leanel A Tabotabo E O'Brian Smith Stephanie H Abrams | 2011 | World Journal of Gastroenterology2011，17，39： | 2 |
| 6 | Regulation of the hypoxiainducible transcription factor 1 alpha by the ubiquitin - proteasome pathway显示文摘 | Kallio PJ Wilson WJ O' Brien S | 1999 | J Biol Chem1999，274，： | 1 |
| 7 | Optimal Entry Time for a Product Line Extension显示文摘 | Wilson L O Norton J A | 1989 | Marketing Science1989，8，： | 1 |
| 8 | The Persistence of Profit -- A New Empirical Interpretatian 显示文摘 | Goddard J A Wilson J O S | 1999 | International Journal of Industrial Organizatian1999，，17： | 1 |
| 9 | The S7 gene and VP7 protein are highly conserved among temporally and geographically distinct American isolates of epizootic hemorrhagic disease virus显示文摘 | MECHAM J O STALLKNECHT D WILSON W C | 2003 | Virus Res2003，94，2： | 1 |
| 10 | Inflamma- tory cells in the airways in COPD 显示文摘 | O'Donnell R Breen D Wilson S | 2006 | Thorax2006，61，5： | 1 |
| 11 | Minimum criteria for immediate provisionalization of single-tooth dental implants in extraction sites:a 1-year retrospective study of 100 consecutive cases显示文摘 | BECKER C M WILSON T J JENSEN O T | 2011 | J Oral Maxillofac Surg2011，69，2： | 1 |
| 12 | Au- tonomic healing of epoxy vinyl esters via ring opening metathesis polymerization 显示文摘 | Wilson G O Moore J S White S R | 2008 | Ad-vanced Functional Materials2008，18，1： | 1 |
| 13 | Instrumentation and monitoring of an engineered soil cover system for mine waste rock显示文摘 | O'KANE M WILSON G W BARBOUR S L | 1998 | Can Geotech J1998，35，5： | 1 |
| 14 | Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering显示文摘 | BONETTI P O WILSON S H RODRIGUEZ-POR- CEL M | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 15 | Beta (3) integrin expression increases breast carcinoma cell responsiveness to the malignancy enhancing effects of osteopontin显示文摘 | Furger K A Allan A L Wilson S M Hota C Vantyghem S A Postenka C O | 2003 | Mol Cancer Res2003，1，： | 1 |
| 16 | Hyperspectral remote sensing technology(HRST) program and the Naval Earth Map Observer (NEM) satellite 显示文摘 | WILSON T H DAVIS C O | 1998 | SPIE1998，3437，： | 1 |
| 17 | Optimal Entry Timing for a Product Line Extension显示文摘 | Wilson Lynn O John A Norton | 1989 | Marketing Science1989，1，： | 1 |
| 18 | Dolomitization front geometry,fluid flow patterns and the origin of massive dolomite 显示文摘 | Wilson E N Hardie L A Phillips O M | 1990 | America Journal of Science1990，290，5： | 1 |
| 19 | Autonomic healing of epoxy vinyl esters via ring opening metathesis polymerization显示文摘 | Wilson G O Moore J S White S R | | 0，，： | 1 |
| 20 | Outcomes from mild and moder- ate traumatic brain injuries among children and adolescents:A system- atic review of studies from 2008-2013 显示文摘 | Lloyd J Wilson ML Tenovuo O | 2015 | Brain Inj2015，29，5： | 1 |
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