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| 1 | Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR显示文摘AIM: To study the effect of the toxic secondary bile acid lithocholic acid (LCA) on the expression of fibroblast growth factor 19 (FGF19) in intestinal cells and to characterize the pregnane-X-receptor (PXR) response of the FGF19 promoter region. METHODS: The intestinal cell line LS174T was stimulated with various concentrations of chenodeoxy-cholic acid and lithocholic acid for several time points. FGF19 mRNA levels were determined with quantitative realtime RT-PCR. FGF19 deletion promoter constructs were generated and the LCA response was analzyed in reporter assays. Co-transfections with PXR and RXR were carried out to study FGF19 regulation by these factors. RESULTS: LCA and CDCA strongly up-regulate FGF19 mRNA expression in LS174T cells in a time and dose dependent manner. Using reporter gene assays with several deletion constructs we found that the LCA responsive element in the human FGF19 promoter maps to the proximal regulatory region containing two poten-tial binding sites for PXR. Overexpression of PXR and its dimerization partner retinoid X receptor (RXR) and stimulation with LCA or the potent PXR ligand rifampicin leads to a signifi cant induction of FGF19 promoter activ-ity in intestinal cells. CONCLUSION: LCA induced feedback inhibition of bile acid synthesis in the liver is likely to be regulated by PXR inducing intestinal FGF19 expression. | Wolfgang Wistuba Carsten Gnewuch Gerhard Liebisch Gerd Schmitz Thomas Langmann | 2007 | World Journal of Gastroenterology2007，13，31： | 4 |
| 2 | 塔里木盆地生长季ET0的时空变化特征及其敏感性分析显示文摘基于塔里木盆地19个气象站2000−2019年生长季逐日气象数据,采用FAO−56PM公式计算各站逐日ET0,运用敏感系数、ArcGIS反距离权重插值、气候倾向率和Mann-Kendall非参数检验等方法,对该地区ET0的时空变化规律及ET0对关键气象因子的敏感性进行分析。结果表明:(1)近20a来,塔里木盆地生长季ET0日均值在空间上呈北低南高的趋势,多年ET0日均值从大到小依次为6、7、5、8、4、9和10月,其值分别为5.84、5.73、5.29、4.95、4.23、3.65和2.17mm⋅d−1,气候倾向率分别为−0.09、0.24、0.11、−0.07、0.16、0.07和0.08mm⋅10a−1,ET0日均值在盆地中、西部以负倾向率为主,盆地东部则以正倾向率为主。(2)整个生长季,塔里木盆地的相对湿度逐月增加,2m处风速逐月减小,日照时数则呈先增加后降低的趋势,最低气温和最高气温均呈倒U形分布,且均在7月达到最大值。相对湿度的变化以负倾向率为主,2m处风速和最低气温的变化以正倾向率为主,日照时数和最高气温变化的倾向率无明显规律。(3)在生长季(4−10月),塔里木盆地ET0对关键气象因子的敏感性表现为最高气温>相对湿度>日照时数>2m处风速>最低气温,ET0对最低气温的敏感性以较低敏感性为主,对其余气象因子均以高敏感性为主。ET0对最低气温和最高气温最敏感的月份是7月,而对相对湿度、2m处风速和日照时数最敏感的月份分别是10月、4月和8月。ET0对相对湿度的敏感系数绝对值的空间分布呈由北向南递减的趋势,对2m处风速和最高气温的敏感系数均以塔克拉玛干沙漠为高值中心,对日照时数无明显规律,对最低气温则呈由西向东递减的趋势。 | 王大刚 于洋 MALIK Ireneusz WISTUBA Malgorzata 张敏 闫小月 孙凌霄 于瑞德 | 2022 | 中国农业气象2022，43，5： | 3 |
| 3 | Spatiotemporal changes in water,land use,and ecosystem services in Central Asia considering climate changes and human activities显示文摘Central Asia is located in the hinterland of Eurasia,comprising Kazakhstan,Uzbekistan,Kyrgyzstan,Turkmenistan,and Tajikistan;over 93.00%of the total area is dryland.Temperature rise and human activities have severe impacts on the fragile ecosystems.Since the 1970s,nearly half the great lakes in Central Asia have shrunk and rivers are drying rapidly owing to climate changes and human activities.Water shortage and ecological crisis have attracted extensive international attention.In general,ecosystem services in Central Asia are declining,particularly with respect to biodiversity,water,and soil conservation.Furthermore,the annual average temperature and annual precipitation in Central Asia increased by 0.30℃/decade and 6.9 mm/decade in recent decades,respectively.Temperature rise significantly affected glacier retreat in the Tianshan Mountains and Pamir Mountains,which may intensify water shortage in the 21st century.The increase in precipitation cannot counterbalance the aggravation of water shortage caused by the temperature rise and human activities in Central Asia.The population of Central Asia is growing gradually,and its economy is increasing steadily.Moreover,the agricultural land has not been expended in the last two decades.Thus,water and ecological crises,such as the Aral Sea shrinkage in the 21st century,cannot be attributed to agriculture extension any longer.Unbalanced regional development and water interception/transfer have led to the irrational exploitation of water resources in some watersheds,inducing downstream water shortage and ecological degradation.In addition,accelerated industrialization and urbanization have intensified this process.Therefore,all Central Asian countries must urgently reach a consensus and adopt common measures for water and ecological protection. | YU Yang CHEN Xi Ireneusz MALIK Malgorzata WISTUBA CAO Yiguo HOU Dongde TA Zhijie HE Jing ZHANG Lingyun YU Ruide ZHANG Haiyan SUN Lingxiao | 2021 | Journal of Arid Land2021，13，9： | 2 |
| 4 | Temporal and spatial variations of net primary productivity and its response to groundwater of a typical oasis in the Tarim Basin, China显示文摘Net primary productivity (NPP) of the vegetation in an oasis can reflect the productivity capacity of a plant community under natural environmental conditions. Owing to the extreme arid climate conditions and scarce precipitation in the arid oasis regions, groundwater plays a key role in restricting the development of the vegetation. The Qira Oasis is located on the southern margin of the Taklimakan Desert (Tarim Basin, China) that is one of the most vulnerable regions regarding vegetation growth and water scarcity in the world. Based on remote sensing images of the Qira Oasis and daily meteorological data measured by the ground stations during the period 2006-2019, this study analyzed the temporal and spatial patterns of NPP in the oasis as well as its relation with the variation of groundwater depth using a modified Carnegie Ames Stanford Approach (CASA) model. At the spatial scale, NPP of the vegetation decreased from the interior of the Qira Oasis to the margin;at the temporal scale, NPP of the vegetation in the oasis fluctuated significantly (ranging from 29.80 to 50.07 g C/(m2•month)) but generally showed an increasing trend, with the average increase rate of 0.07 g C/(m2•month). The regions with decreasing NPP occupied 64% of the total area of the oasis. During the study period, NPP of both farmland and grassland showed an increasing trend, while that of forest showed a decreasing trend. The depth of groundwater was deep in the south of the oasis and shallow in the north, showing a gradual increasing trend from south to north. Groundwater, as one of the key factors in the surface change and evolution of the arid oasis, determines the succession direction of the vegetation in the Qira Oasis. With the increase of groundwater depth, grassland coverage and vegetation NPP decreased. During the period 2008-2015, with the recovery of groundwater level, NPP values of all types of vegetation with different coverages increased. This study will provide a scientific basis for the rational utilization and sustainable management of groundwater resources in the oasis. | SUN Lingxiao YU Yang GAO Yuting ZHANG Haiyan YU Xiang HE Jing WANG Dagang Ireneusz MALIK Malgorzata WISTUBA YU Ruide | 2021 | Journal of Arid Land2021，13，11： | 2 |
| 5 | Fragile histidine triad(FHIT)gene abnormalities in lung cancer显示文摘 | Zochbauer-Muller S Wistuba II Minna JD | 2000 | Clin Lung Cancer2000，2，2： | 1 |
| 6 | Deletions of chro- mosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma 显示文摘 | Wistuba II Montellano FD Milchgrub S | 1997 | Cancer Res1997，57，15： | 1 |
| 7 | Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry 显示文摘 | Shen J Behrens C Wistuba I I | 2006 | Cancer Res2006，66，11： | 1 |
| 8 | Recent progress in enantiomer separation by capillary eleetrochromatography 显示文摘 | Wistuba D Schurig V | 2000 | Electrophoresis2000，21，： | 1 |
| 9 | Molecular genetics of small cell lung carcinoma显示文摘 | Wistuba Ⅱ Gazdar AF Minna JD | 2001 | Semin Oncol2001，28，2： | 1 |
| 10 | Gallbladder cancer: lessons from a rare tumour显示文摘 | Wistuba II Gazdar AF | 2004 | Nat Rev Cancer2004，4，9： | 1 |
| 11 | Application of eccentric growth of trees as a tool for landslide analyses : the example of Pi- cea abies Karst ,in the Carpathian and Sudetan Mountains( Central Europe) 显示文摘 | Wistuba M Malik I Gartner H | 2013 | Catena2013，111，2013： | 1 |
| 12 | Molecular genetics of srnall cell lung carcinoma显示文摘 | Wistuba II Gazdar AF Minna JD | 2001 | Semin Oneo12001，28，： | 1 |
| 13 | Human pap illomavirus typele is detected in transitional cell carcinomas and squamoranistional cell carci- nomas of the cervix and endometrium 显示文摘 | ininger RA Wistuba I GazdarA | 1998 | Cancer1998，83，3： | 1 |
| 14 | Molecular damage in the bronchial epithelium of current and former smokers 显示文摘 | Wistuba II Lam S Behrens C | 1997 | J Natl Cancer Inst1997，89，18： | 1 |
| 15 | Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas 显示文摘 | WISTUBA II MIQUEL JF GAZDAR AF | 1999 | Hum Pathol1999，30，1： | 1 |
| 16 | Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas显示文摘 | Flowers L C Wistuba I I Scurry J | 1999 | J Soc Gynecol Investiq1999，6，4： | 1 |
| 17 | Distinct K- ras mutation pattern characterizes signet ring cell colorectal eareinoma显示文摘 | Wistuba II Behrens C Albores-saavedra J | 2003 | Clin Cancer Res2003，9，10： | 1 |
| 18 | High resolution chromosome 3p alleotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoits 显示文摘 | Wistuba Ⅱ Behrens C Virmani AK | 2000 | Cancer Res2000，60，7： | 1 |
| 19 | Clinical and biological feature associated with epidermal growth factor receptor gene mutations in lung cancers 显示文摘 | Shigematsu H Lin L Takahashi T Nomura M Suzuki M Wistuba H | 2005 | J Natl Cancer lnst2005，97，5： | 1 |
| 20 | Molecular damage in the bronchial epithelium of current and former smokers显示文摘 | Wistuba I I Lam S Behrens C | 1997 | J Natl Cancer Inst1997，89，： | 1 |
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