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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Stem cells in normal breast development and breast cancer 显示文摘 | Dontu G Al - Hajj M Abdallah WM | 2003 | Cell Prolif2003，36，1： | 1 |
| 4 | Biomarker discovery in neurodegenerative diseasess:a proteomic approach显示文摘 | Shi M Caudle WM Zhang J | 2009 | Neurobiol Dis2009，35，2： | 1 |
| 5 | Human bone marrow stein cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the isehemic brain of rats显示文摘 | Zhao LR Duan WM Reyes M | 2002 | Exp Neurol2002，174，1： | 1 |
| 6 | Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats显示文摘 | Zhao LR Duan WM Reyes M | 2002 | Exp Neurol2002，174，1： | 1 |
| 7 | Complications of labor analgesia :epidural versus combined spinal epidural techniques显示文摘 | Norris MC Grieco WM Borkowski M | 1994 | Anesth Analg1994，79，3： | 1 |
| 8 | Fractures of the proximal third of the tibial shaft treated with intramedullary nails and blocking screws显示文摘 | Ricci WM 0 'Boyle M Borrelli J | 2001 | J Orthop Trauma2001，15，4： | 1 |
| 9 | The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum 显示文摘 | South M Ozonoff S McMahon WM | 2007 | Autism2007，11，5： | 1 |
| 10 | Unilateral cervical surgical exploration aided by intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism and equivocal sestamibi wan results显示文摘 | Goldstein RE Carter WM Fleming M | 2006 | Arch Surg2006，141，6： | 1 |
| 11 | Potency of bupivicaine stereoisomers tested in vitro and in vivo biochemical electrophysiological and neurobehavioral显示文摘 | Vladimirov M Nau C Mok WM | 2000 | Anesthesiology2000，93，： | 1 |
| 12 | Osteonecrosis after powered core decompression 显示文摘 | Mihalko WM Balos L Sanrilli M | 2003 | Clin Orthop Relat Res2003，4，1： | 1 |
| 13 | Electromyographic analysis of upperbody, lower body, and abdominal muscles during advancedSwiss ball exercises 显示文摘 | WM M P IMTIAZ D | 2010 | J Strength Cond Res2010，24，6： | 1 |
| 14 | Human bone ma-rrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats显示文摘 | Zhao LR Duan WM Reyes M | | 0，，： | 1 |
| 15 | A reap- praisal of the epidemiology of muhiple scleros is in Olm- sted County, Min nesota 显示文摘 | Wynn D R Rodriguez M Ofallon WM | 1990 | Neurology1990，40，5： | 1 |
| 16 | Polyamines can increase resistance ofNeisseria gonorrhoeae to mediators of the innate human host defense显示文摘 | Goytia M Shafer WM | | 0，，07： | 1 |
| 17 | Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia:triggering the differentiation syndrome显示文摘 | Luesink M Pennings JL Wissink WM | | 0，，27： | 1 |
| 18 | Fundamental relationship of fabric extensibility to anthropometric requirements and garment performanee显示文摘 | Wm Kirk Jr S M Ibrahirn | 1966 | T R J1966，57，： | 1 |
| 19 | Pattern of metastatic spread in triple-negative breast cancer 显示文摘 | Dent R Hanna WM Trudeau M | 2009 | Breast Cancer Res Treat2009，115，2： | 1 |
| 20 | Single-incision laparoscopic surgery(SILS)in complex colorectal sur gery:a technique offering potential and not just cosmesis显示文摘 | Chambers WM Bicsak M Lamparelli M | 2011 | Colorectal Dis2011，13，4： | 1 |
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