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| 1 | High-frequency ultrasound features of basal cell carcinoma and its association with histological recurrence risk显示文摘Background: Due to advances in high-frequency ultrasound technology, it is easier to detect fine structures of skin lesions. The aim of this study was to examine the ultrasonographic features and use recurrence risk stratification to assess the diagnostic performance of pre-operative ultrasound examination of basal cell carcinoma (BCC). Methods: This was a retrospective study. Forty-six BCC lesions underwent pre-operative ultrasound examination using 50- and 20- MHz probes. Ultrasonographic shape, margin, internal echoes, hyper-echoic spots, posterior echoes, and depth of the lesion were evaluated and correlated with the risk of recurrence based on histological features. Results: Forty-two patients had 46 skin lesions in total. The high-risk (n = 6) and low-risk (n = 40) groups exhibited considerable overlap in the ultrasonographic manifestations and no significant difference in margin (χ^2 = 3.231, P = 0.072), internal echo (χ^2 = 1.592, P = 0.207), or posterior echo (P = 0.169). However, high-risk BCCs tended to be irregular in shape than low-risk lesions (χ^2 = 4.313, P = 0.038). Both types presented hyper-echoic spots (χ^2 = 1.850, P = 0.174). Additionally, 78% of low-risk lesions were confined to the dermis (31/40), and 100% of high-risk lesions infiltrated into the sub-cutaneous tissue, resulting in a significant difference between the two groups (χ^2 = 10.951, P = 0.001). Ultrasound detected sub-clinical lesions in five patients. Conclusions: High-frequency ultrasound can provide important information for pre-operative evaluation of risk in BCC foci and reveal hidden lesions. The technique may play a crucial role in guiding therapeutic options for BCC. | Shi-Qi Wang Jie Liu Qing-Li Zhu Chen-Yang Zhao Tao Qu Feng Li Ximena Wortsman Hong-Zhong Jin | 2019 | Chinese Medical Journal2019，，17： | 12 |
| 2 | Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress显示文摘 | Andrzej Slominski Jacobo Wortsman Thomas Luger | 2000 | Physiol Rev2000，80，： | 1 |
| 3 | Hashimoto's thyroiditis simulating cancer of the thyroid显示文摘 | Wortsman J Dietrich J Apesos J | 1981 | Arch Surg1981，116，4： | 1 |
| 4 | Treatment of Hashimoto's disease显示文摘 | WORTSMAN J HILL JE Schultz | 1981 | ArchSurg1981，116，4： | 1 |
| 5 | Decreased bioavailability of vitamin D in obesity显示文摘 | Wortsman J Matsuoka LY Chen TC | 2000 | Am J Clin Nutr2000，72，4： | 1 |
| 6 | Human skin expresses growth hormone but not the prolactin gene显示文摘 | SLOMINSKI A MALARKEY W B WORTSMAN J | 2000 | Lab Clin Med2000，136，： | 1 |
| 7 | Malignant melanoma显示文摘 | Slominski A Wortsman J Carlson AJ | 2001 | Arch Pathol Lab Med2001，125，10： | 1 |
| 8 | Hair follicle pigmentation显示文摘 | Slominski A Wortsman J Plonka PM | 2005 | J Invest Dermatol2005，124，1： | 1 |
| 9 | Hair follicle pigmentation显示文摘 | Slominski A Wortsman J Plonka PM | 2005 | J Invest Dermatol2005，124，1： | 1 |
| 10 | Malignant melanoma 显示文摘 | Slominski A Wortsman J Carlson AJ | 2001 | Arch Pathol Lab Med2001，125，10： | 1 |
| 11 | Corticotropin releasinghormone and proopiomelanocortin involvement in the cutaneousresponse to stress显示文摘 | Slominski A Wortsman J Luger T | 2000 | Physiol Rev2000，80，： | 1 |
| 12 | Hair follicle pigmentation显示文摘 | Slominski A Wortsman J Plonka PM | 2005 | J Invest Dermatol2005，124，1： | 1 |
| 13 | Clothing prevents ultraviolet-B radiationdependent photosynthesis of vitamin D3显示文摘 | Matsuoka LY Wortsman J Dannenberg MJ | 1992 | J Clin Endocrinol Metab1992，75，4： | 1 |
| 14 | Self-regulated endocrine systems in the skinl显示文摘 | Slominski A Wortsman J | 2003 | Minerva Endocrinol2003，28，2： | 1 |
| 15 | T-lym- phocyte activation in adult-onset idiopathic hypoparathy- roidism 显示文摘 | Wortsman J Mceonnachie P Baker JJ | 1992 | Am J Med1992，92，： | 1 |
| 16 | Corticotropin releasing hormone and proopiome lanocortin involvement in the cutaneous response to stress显示文摘 | Slominski A Wortsman J Luger T | 2000 | Physiol Rev2000，80，3： | 1 |
| 17 | Functional responses to extremely high plasma epnephrine concentrations in cardiac arrest显示文摘 | Wortsman J Paradis NA Martin GB | 1993 | Crit Care Med1993，21，5： | 1 |
| 18 | Hair follicle pigmentation 显示文摘 | Slominski A Wortsman J Plonka PM | 2005 | J Investigat Dermatol2005，124，1： | 1 |
| 19 | Treatment of Hashimoto's disease显示文摘 | Wortsman J Hill JE Schuitz GF | 1981 | Arch Surg1981，116，4： | 1 |
| 20 | Expression of hypothalamic - pituitary -thyroid axis related genes in the human skin显示文摘 | Slominski A Wortsman J Kohn L Ain KB Venkataraman GM Pisarchik A Chung JH Giuliani C Thornton M Slugocki G Tobin DJ | 2002 | J Invest Dermatol2002，119，6： | 1 |
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