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| 1 | TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis显示文摘AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis. | Yang SS Wu CH Chen TH Huang YY Huang CS | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Intrahepatic transplantation of hepatic oval cells for fulminant hepatic failure in rats显示文摘AIM:To evaluate the effect of intrahepatic transplantation of hepatic oval cells(HOC)on fulminant hepatic failure(FHF)in rats.METHODS:HOC obtained from rats were labeled with green fluocescent protein(GFP)or 5,6carboxyfluorescein diacetate succinmidyl ester(CFDASE).Cell fluorescence was observed under fluorescent microscope at 6,24,48 and 72 h after labeling.CFDASE labeled HOC(5×10 6 cells each rat)were injected into livers of rats with FHF induced by D-galactosamine.Serum albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)levels were measured at different time points.Liver function of rats was examined on days 3,7,14 and 21 after HOC transplantation.RESULTS:The positive rate of GFP and CFDA-SE labeled HOC was 10%and 90%,respectively,with no significant change in cell viabilities.The survival rate was higher in HOC transplantation group than in control group,especially 48(9/15 vs 6/15)and 72 h(9/15 vs 4/15)after HOC transplantation.The serum ALT,AST and TBil levels were decreased while the serum Alb level was increased after HOC transplantation.Fluorescence became faded and diffused in liver tissues,suggesting that proliferation and differentiation occur in transplanted HOC.CONCLUSION:CFDA-SE is superior to GFP in labeling HOC,although fluorescence intensity is decreased progressively with cell division.HOC transplantation can improve the liver function and increase the survival rate of recipients. | Chen-Xuan Wu,Qi Zou,Zheng-Yan Zhu,Ying-Tang Gao,Yi-Jun Wang,Department of Hepatobiliary,The Third Center of Affiliated Hospital of Tianjin Medical University Key Laboratory of Artificial Cells of Tianjin,Tianjin 300170,China Author contributions:Wang YJ,Wu CH and Zou Q designed the research Zou Q,Zhu ZY,Gao YT performed the research Zou Q analyzed the data Wang YJ and Wu CX wrote the paper.Supported by Tianjin Science Committee,Grant No.05SYSYJC02600 and Tianjin Health Bureau,Grant No.05KYR01 | 2009 | World Journal of Gastroenterology2009，15，12： | 7 |
| 3 | Endoscopic hemoclip treatment for bleeding peptic ulcer显示文摘AIM To evaluate the efficacy of endoscopichemoclip in the treatment of bleeding pepticulcer.METHODS Totally,40 patients with F1a andFib hemorrhagic activity of peptic ulcers wereenrolled in this uncontrolled prospective studyfor endoscopic hemoclip treatment.We used anewly developed rotatable clip-device for theapplication of hemoclip(MD850)to stopbleeding.Endoscopy was repeated if there wasany sign or suspicion of rebleeding,and re-clipping was performed if necessary andfeasible.RESULTS Initial hemostatic rate by clippingwas 95%,and rebleeding rate was only 8%.Ultimate hemostatic rates were 87%,96%,and93% in the Fla and Flb subgroups,and totalcases,respectively.In patients with shock onadmission,hemoclipping achieved ultimatehemostasis of 71% and 83% in F1a and F1bsubgroups,respectively.Hemostasis reached100% in patients without shock regardless ofhemorrhagic activity being F1a or F1b.Theaverage number of clips used per case was 3.0(range 2-5).Spurting bleeders required moreclips on average than did oozing bleeders(3.4versus 2.8).We observed no obviouscomplications,no tissue injury,or impairmentof ulcer healing related to hemoclipping.CONCLUSION Endoscopic hemoclip placementis an effective and safe method.With theimprovement of the clip and application device,the procedure has become easier and much moreefficient.Endoscopic hemoclipping deservesfurther study in the treatment of bleeding pepticulcers. | Lai YC Yang SS Wu CH Chen TK | 2000 | World Journal of Gastroenterology2000，6，1： | 6 |
| 4 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 5 | 不同血管紧张素转换酶抑制剂与高血压患者整体和病因特异性死亡率的相关性显示文摘血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)已广泛用于治疗高血压,比较不同药物降低死亡率有效性的研究却鲜有报道。方法:选取中国台湾地区全民健康保险数据库中从2004年1月1日至2009年12月31日开始用卡托普利、赖诺普利、依那普利、福辛普利、雷米普利、咪达普利或培哚普利治疗的高血压患者。整体和病因特异性死亡率通过中国台湾地区全民死亡登记来证实。从最初用ACEI开始随访患者直至死亡、退出研究或研究终止(2010年12月31日)。 | Chang CH Lin JW Caffrey JL Wu LC Lai MS | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 6 | Laparoscopic partial adrenalectomy for aldosterone-producing adenomas with needlescopic instruments显示文摘 | Liao CH Chueh SC Wu KD | 2006 | Urology2006，，03： | 2 |
| 7 | Endostatin gene therapy delivered by Salmonella choleraesuis in murine tumor models 显示文摘 | Lee CH Wu CL Shiau AL | 2004 | J Gene Med2004，6，12： | 1 |
| 8 | Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan显示文摘 | Wu PF Lee CH Wang MJ | 2004 | Eur J Cancer2004，40，： | 1 |
| 9 | Cellular senescence is an important mechanism of tumor regression upon c-myc inactivation显示文摘 | WU CH Riggelen J Yetil A | 2007 | PNAS2007，104，13： | 1 |
| 10 | Vertebral artery dissection and cerebellar infarction following chiropractic manipulation显示文摘 | Chen WL Chern CH Wu YL | 2006 | Emerg Med J2006，23，1： | 1 |
| 11 | Use of dynamic capillaroscopy for studying cutaneous microcirculation in patients with diabetes mellitus显示文摘 | Chang CH Tsai RK Wu WC | 1997 | Microvas Res1997，53，2： | 1 |
| 12 | Combined anterior and pos- terior surgeries in the treatment of spinal tuberculous Spondylitis 显示文摘 | Chen W J Wu CC Jtmg CH el al | 2002 | Clin Orthop Relat Res2002，39，8： | 1 |
| 13 | Augmentation of vestibular evoked myogenic potentials:an indication for distended saccular hydrops显示文摘 | Young YH Wu CC Wu CH | 2002 | Laryngoscope2002，112，： | 1 |
| 14 | Quiescent infected nonunion of a tibia treated by intramedullary reaming with external fixation 显示文摘 | Wu CC Shih CH Chen WJ | 1997 | J Orthop Surg( Hong Kong)1997，5，： | 1 |
| 15 | Psychometric analysis of the short-form UCLA Loneliness Scale(ULS-8) in Taiwanese undergraduate students显示文摘 | Wu CH Yao G | 2008 | Pers Individ Dif2008，44，8： | 1 |
| 16 | Second-line therapy for elderly patients- with non-small cell lung cancer who failed previous chemotherapy is as ef- fective as for younger patients 显示文摘 | Wu CH Fan WC Chen YM | 2010 | J Thorac Oncol2010，5，3： | 1 |
| 17 | A novel peptide enhancestherapeutic efficacy of liposomal anti-cancer drugs in mice modelsof human lung cancer显示文摘 | Chang DK Lin CT Wu CH | 2009 | PLoS One2009，4，1： | 1 |
| 18 | Clostridium difficile infection at a medical center in southern Taiwan: incidence, clinical features and prognosis显示文摘 | Chung CH Wu C J Lee HC | 2010 | J Microbiol Immunol Infect2010，43，2： | 1 |
| 19 | Glutamate release and neurologic impairment after intrathecal administration of lidocaine and bupivacaine in the rat显示文摘 | Cherng CH Wong CS Wu CT | | 0，，05： | 1 |
| 20 | Oxidative stress response elicited by mitochondrial dysfunction: hnplication in the pathophysiology of aging 显示文摘 | Wang CH Wu SB Wu YT et at | 2013 | Experimental Biology and Medicine2013，238，5： | 1 |
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