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| 1 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 2 | Polychlorinated biphenyls in the atmosphere of Taizhou,a major e-waste dismantling area in China显示文摘PM2.5,total suspended particles(TSP) and gas phase samples were collected at two sites of Taizhou,a major e-waste dismantling area in China.Concentrations,seasonal variations,congener profiles,gas-particle partitioning and size distribution of the atmospheric polychlorinated biphenyls(PCBs) were studied to assess the current state of atmospheric PCBs after the phase out of massive historical dismantling of PCBs containing e-wastes.The average 38PCBs concentration in the ambient air(TSP plus gas phase) near the e-waste dismantling area was(12,407 ± 9592) pg/m3 in winter,which was substantially lower than that found one decade ago.However,the atmospheric PCBs level near the e-waste dismantling area was 54 times of the reference urban site,indicating that the impact of the historical dismantling of PCBs containing e-wastes was still significant.Tri-Penta-CBs were dominant homologues,consisting with their dominant global production.Size distribution of particle-bound PCBs showed that higher chlorinated CBs tended to partition more to the fine particles,facilitating its long range air transportation. | Wenliang Han Jialiang Feng Zeping Gu Minghong Wu Guoying Sheng Jiamo Fu | 2010 | Journal of Environmental Sciences2010，22，4： | 18 |
| 3 | Cotton GhMYB7 is predominantly expressed in developing fibers and regulates secondary cell wall biosynthesis in transgenic Arabidopsis显示文摘The secondary cell wall in mature cotton fibers contains over 90%cellulose with low quantities of xylan and lignin.However,little is known regarding the regulation of secondary cell wall biosynthesis in cotton fibers.In this study,we characterized an R2R3-MYB transcription factor,Gh MYB7,in cotton.Gh MYB7 is expressed at a high level in developing fibers and encodes a MYB protein that is targeted to the cell nucleus and has transcriptional activation activity.Ectopic expression of Gh MYB7 in Arabidopsis resulted in small,curled,dark green leaves and also led to shorter inflorescence stems.A cross-sectional assay of basal stems revealed that cell wall thickness of vessels and interfascicular fibers was higher in transgenic lines overexpressing Gh MYB7 than in the wild type.Constitutive expression of Gh MYB7 in Arabidopsis activated the expression of a suite of secondary cell wall biosynthesis-related genes(including some secondary cell wall-associated transcription factors),leading to the ectopic deposition of cellulose and lignin.The ectopic deposition of secondary cell walls may have been initiated before the cessation of cell expansion.Moreover,Gh MYB7 was capable of binding to the promoter regions of At SND1 and At Ces A4,suggesting that Gh MYB7 may function upstream of NAC transcription factors.Collectively,these findings suggest that Gh MYB7 is a potential transcriptional activator,which may participate in regulating secondary cell wall biosynthesis of cotton fibers. | Junfeng Huang Feng Chen Siyu Wu Juan Li Wenliang Xu | 2016 | Science China(Life Sciences)2016，59，2： | 15 |
| 4 | Diurnal variations of polycyclic aromatic hydrocarbons associated with PM_(2.5) in Shanghai, China显示文摘Forty-eight daily time interval PM2.5 samples were collected from December 2006 to January 2008 in an urban site in Shanghai, China. Concentrations and compositions of polycyclic aromatic hydrocarbons (PAHs) were analyzed with GC-MS to study the diurnal and seasonal variations and to identify the main emitting sources. The diurnal variation of the PAHs concentrations was greater in the late autumn and winter sampling days, and was greatly influenced by meteorological conditions such as wind speed and ambient temperature. The concentration of PAHs in the mornings (6:30-10:00) increased distinctly, and was high in the late autumn and winter sampling days, indicating the contribution from vehicle emissions during rush hours. The diurnal variation of the high molecular weight PAHs did not seem to be controlled by the shift of gas-particle partitioning due to temperature variation, instead, it could be indicative of the variation in the source. Statistical analyses showed that the concentrations of PAHs were negatively correlated with temperature and wind speed, and positively correlated with relative humidity. Diagnostic ratios of PAHs suggested mixed emission sources of petroleum and coal/biomass combustion for PAHs in the PM2.5 in Shanghai. | Zeping Gu Jialiang Feng Wenliang Han Li Li Minghong Wu Jiamo Fu Guoying Sheng | 2010 | Journal of Environmental Sciences2010，22，3： | 13 |
| 5 | Novel cotton homeobox gene and its expression profiling in root development and in response to stresses and phytohormones显示文摘Homeodomain 白氨酸拉链(HD 压缩) 蛋白质是涉及植物开发的 transcriptional 因素。在这研究,一 cDNA 克隆(Gossypium hirsutum homeobox1,指明的 GhHB1 ) 编码 HD 压缩蛋白质从一个棉花根 cDNA 图书馆被孤立。GhHB1 cDNA 是在长度的 1132 bp,包括 828 bp 与 275 氨基酸编码肽的开的读框架,和 5'-/3'-untranslated 区域。包含 homeodomain 和一个充满白氨酸的拉链主题的预言的 GhHB1 蛋白质与另外的植物 HD 压缩蛋白质分享相对高的身份。用量的即时 RT-PCR 的分析显示 GhHB1 基因主要在根和胚轴被表示。而且, GhHB1 抄本大部分在早根开发被积累,并且显著地减少了,建议基因可能在根的早开发工作很,根推进的底层发展了。在有 1% NaCl 的处理下面, GhHB1 基因的表示水平戏剧性地在根被增加。同样,在根的 GhHB1 活动由 abscisic 是起来调整的。这些结果暗示 GhHB1 可能响应盐应力并且到 abscisic 发信号起一个重要作用。 | Yongxiang Ni Xiulan Wang Dengdi Li Yajie Wu Wenliang Xu Xuebao Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 12 |
| 6 | Iron Aggravates the Depressive Phenotype of Stressed Mice by Compromising the Glymphatic System显示文摘Dear Editor,The pathophysiologic al mechanisms underlying mood disorders including major depressive disorder(MDD)remain to be fully characterized.Iron is a key component in the development of the central nervous system and iron deficiency has been linked to impairments of mood and cognition[1]. | Shanshan Liang Yan Lu Zexiong Li Shuai Li Beina Chen Manman Zhang Binjie Chen Ming Ji Wenliang Gong Maosheng Xia Alexei Verkhratsky Xu Wu Baoman Li | 2020 | Neuroscience Bulletin2020，36，12： | 5 |
| 7 | 5-氟尿嘧啶和卡培他滨对中国患者的心脏毒性:一项前瞻性研究显示文摘背景与目的已有许多研究报道5-氟尿嘧啶(5-Fluorouracil,5-FU)和卡培他滨相关的心脏毒性,严重程度从无症状心电图(electrocardiography,ECG)异常到严重心肌梗塞而不同。目前为止,对中国恶性肿瘤患者的这种心脏毒性尚无研究。本研究旨在前瞻性地对多个中心招募的癌症患者进行5-FU和卡培他滨相关心脏毒性的发生率和临床表现进行评估。方法在完成研究的527例患者中,196例接受基于5-FU的化疗,331例接受基于卡培他滨的化疗并以其为一线或辅助治疗。在治疗期间和长达28 d的随访期间对所发生的不良反应进行记录。疗效测量指标包括心电图、心肌酶、心肌肌钙蛋白、脑钠肽和超声心动图。使用单因素分析和logistic回归方法进行亚组分析和鉴定与两种药物的心脏毒性相关的显著性独立变量。结果 527例患者中有161例(30.6%)出现心脏毒性。卡培他滨组的心脏毒性发生率为33.8%(112/331),显著高于5-FU组25%(49/196)的发生率(P=0.0042)。110/527患者(20.9%)发生心律失常,105/527(19.9%)发生缺血性改变,而只有20/527患者(3.8%)出现心力衰竭,6/527患者(1.1%)出现心肌梗塞。既往的心脏病、高血压、卡培他滨为基础的化疗和治疗时间被确定为与心脏毒性相关的显著风险因素。优势比分别为15.7(心脏病史vs.无病史)、1.86(卡培他滨vs. 5-FU)、1.06(5–8个化疗周期vs. 1–4个化疗周期)和1.58(高血压vs.无高血压)。结论氟嘧啶类药物在中国人群中引起的心脏毒性可能在临床实践中被低估。建议密切监测患者,尤其是对心脏毒性高风险的患者。可能的风险因素包括治疗持续时间、基于卡培他滨的化疗、既往心脏病史和高血压史。 | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | 癌症2018，37，10： | 3 |
| 8 | Payments for watershed ecosystem services:mechanism,progress and challenges显示文摘Introduction:Payment for watershed ecosystem services(PWES),a policy instrument for compensating for the externality of watershed ecosystem/environmental services,has gained in policy importance in China over the past two decades.Many scholars and researchers have contributed to the conceptualization of this policy framework by developing operational mechanisms as well as compensation standards for PWES.Outcomes:This article reviews 27 PWES schemes piloted in China and in 10 other countries,with a particular emphasis on successful cases of land-use conversion programs,such as the Paddy Land to Dry Land Program and Sloping Land Conversion Program that have been implemented in China.Discussion:By comparing different cases,the authors attempt to answer the following questions:what were the ecological and institutional contexts in which these schemes were established and how did they work?What were the actual efficiencies and impacts of these piloted schemes?Which scheme worked better in certain ecological,socio-economic,and institutional contexts?Conclusion:Based on case studies,the authors draw the following conclusions about Chinese PWES:(1)to establish an acceptable standard for a PWES program,it is necessary to estimate the economic and social costs regarding the livelihoods of households;(2)multistakeholder negotiation mechanism for PWES,including intermediaries,such as the local government,NGO/NPOs,village committees,and user associations,should be used;(3)ES,non-market services,should acquire positive externalities to accomplish an optimal win–win pattern concerning both environmental goals and the livelihoods of local resource users. | Danyang Feng Wenliang Wu Long Liang Li Li Guishen Zhao | 2018 | Ecosystem Health and Sustainability2018，4，1： | 2 |
| 9 | Analysis of changes in the structure of rural household energy consumption in northern China: A case study显示文摘 | Zhongren Zhou Wenliang Wu Xiaohua Wang Qun Chen Ou Wang | 2007 | Renewable and Sustainable Energy Reviews2007，，1： | 2 |
| 10 | Effects of conservation tillage practices on winter wheat water-use efficiency and crop yield on the Loess Plateau, China显示文摘 | Ziyou Su Jinsong Zhang Wenliang Wu Dianxiong Cai Junjie Lv Guanghui Jiang Jian Huang Jun Gao Roger Hartmann Donald Gabriels | 2006 | Agricultural Water Management2006，，3： | 2 |
| 11 | Thickness-Shear Frequencies of an Infinite Quartz Plate with Graded Material Properties Across the Thickness显示文摘For quartz crystal resonators of thickness-shear type,the vibration frequency and mode shapes reflect the basic material and structural properties of a quartz crystal plate and the variation with time under attack by erosive gases and liquids that can cause surface and internal degradation in a graded form.Such gradual effects,in turn,will change surface conditions through elastic constants and stiffness and more importantly the gradient of such properties across the thickness with certain depth.Now we study the thickness-shear vibrations of functionally graded material plates with properties of the popular AT-cut quartz crystal varying across the thickness in a general pattern represented by both sine and cosine components of the thickness.The vibration solutions are obtained through the Fourier expansion of the plate deformation. | Rongxing Wu Wenliang Zhang Tingfeng Ma Jianke Du Ji Wang | 2020 | Acta Mechanica Solida Sinica2020，33，3： | 2 |
| 12 | Structural change and carbon emission of rural household energy consumption in Huantai, northern China显示文摘 | Long Liang Wenliang Wu Rattan Lal Yanbin Guo | 2013 | Renewable and Sustainable Energy Reviews2013，，： | 2 |
| 13 | Preparation of Exo-tetrahydrodicyclopentadiene Using SiW/Hβ Catalyst显示文摘Exo-tetrahydrodicyclopentadiene (exo-TCD) is an important high-energy fuel.Silicotungstic acid (SiW) immobilized on H-type β zeolite (Hβ) at room temperature were used to prepare the Hβ zeolite catalysts with different SiW contents.Catalytic performances of the catalysts were investigated during the preparation of exo-TCD via isomerization of endo-tetrahydrodicyclopentadiene (endo-TCD).The properties of catalysts were characterized by XRD,temperature pro-grammed desorption of ammonia (NH 3-TPD),FT-IR,and N 2-adsorption techniques.SiW was highly dispersed on the surface of Hβ zeolite,and the 10% SiW/Hβ zeolite catalyst had the highest amount of weak acidity among all SiW/Hβ zeolite catalysts.The influence of different factors on isomerization reaction was investigated.At a reaction temperature of 240 ℃,a n(cyclohexane) /n(endo-TCD) ratio of 10,a m(catalyst) /m(endo-TCD) ratio of 0.3,an initial pressure of 1.0 MPa,and a reaction time of 1.5 h in the presence of 10% SiW/Hβ catalyst calcined at 400 ℃,the conversion of endo-TCD reached up to 92.0%,with the yield of exo-TCD equating to 51.0%. | Kang Zhuozhuo Wu Wenliang Zhou Zhiwei (College of Chemistry and Chemical Engineering,Nanjing University of Technology,Nanjing 210009) | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，3： | 2 |
| 14 | Influence of water pipe cooling on thermal stresses in mass concrete显示文摘 | Bai Xinli Wu Zeyu Ma Wenliang | | 0，，： | 1 |
| 15 | CO_(2)emission and source partitioning from carbonate and non-carbonate soils during incubation显示文摘The accurate quantification and source partitioning of CO_(2)emitted from carbonate(i.e.,Haplustalf)and non-carbonate(i.e.,Hapludult)soils are critically important for understanding terrestrial carbon(C)cycling.The two main methods to capture CO_(2)released from soils are the alkali trap method and the direct gas sampling method.A 25-d laboratory incubation experiment was conducted to compare the efficacies of these two methods to analyze CO_(2)emissions from the non-carbonate and carbonate-rich soils.An isotopic fraction was introduced into the calculations to determine the impacts on partitioning of the sources of CO_(2)into soil organic carbon(SOC)and soil inorganic carbon(SIC)and into C3 and/or C4 plant-derived SOC.The results indicated that CO_(2)emissions from the non-carbonate soil measured using the alkali trap and gas sampling methods were not significantly different.For the carbonate-rich soil,the CO_(2)emission measured using the alkali trap method was significantly higher than that measured using the gas sampling method from the 14 th day of incubation onwards.Although SOC and SIC each accounted for about 50%of total soil C in the carbonate-rich soil,SOC decomposition contributed 57%–72%of the total CO_(2)emitted.For both non-carbonate and carbonate-rich soils,the SOC derived from C4 plants decomposed faster than that originated from C3 plants.We propose that for carbonate soil,CO_(2)emission may be overestimated using the alkali trap method because of decreasing CO_(2)pressure within the incubation jar,but underestimated using the direct gas sampling method.The gas sampling interval and ambient air may be important sources of error,and steps should be taken to mitigate errors related to these factors in soil incubation and CO_(2)quantification studies. | Yi ZHAO Roland BOL Zhaoan SUN Yuping ZHUGE Xiaoxia SHI Wenliang WU Fanqiao MENG | 2022 | Pedosphere2022，32，3： | 1 |
| 16 | Effects of on winter wheat water-use the loess plateau, china显示文摘 | Ziyou Su Jinsong Zhang conservation tillage practices efficiency and crop yield on Agriculture water management Wenliang Wu | 2007 | 87: 307-3142007，87，： | 1 |
| 17 | Analysis of changes in the structure of rural household energy consumption in northern China: A case study显示文摘 | Zhou Zhongren Wu Wenliang Wang Xiaohua | 2009 | Renewable and Sustainable Energy Reviews2009，13，1： | 1 |
| 18 | Characterization of 12-tungstophosphoric acid impregnated on mesoporous silica SBA-15 and its catalytic performance in isopropylation of naph- thalene with isopropanol 显示文摘 | Liu Qiying Wu Wenliang Wang Jun | 2004 | Microporous Mesoporous Mater2004，76，1： | 1 |
| 19 | The effects of land use change and irrigation water resource on nitrate contamination in shallow groundwater at county scale显示文摘 | Chen Shufeng Wu Wenliang Hu Kelin | 2010 | Ecological Complexity2010，7，2： | 1 |
| 20 | Expression and localization of GhH6L, a putative classical arabinogalactan protein in cotton (Gossypium hirsutum)显示文摘Arabinogalactan 蛋白质(AGP ) 是一个大家庭高度 hydroxyproline 富有的 glycoproteins 的 glycosylated 在植物生长,开发,和信号 transduction 起重要作用。编码通常认为的古典 AGP 说出 GhH6L 的 cDNA 从棉花纤维 cDNA 图书馆被孤立,并且推出的蛋白质包含 XYprolineprolineproline 的重复主题的 17 个拷贝(在 X 是的地方,丝氨酸或丙氨酸和 Y 是 threonine 或丝氨酸) 。北弄污分析和量的 RTPCR 结果证明它优先地在 10 天内被表示开花期以后(dpa ) 纤维并且发展地也被调整。倡导者碎片被走 PCR 的染色体从棉花(Gossypium hirsutum ) 孤立。-glucuronidase (GUS ) 的表示在 GhH6L 倡导者下面的基因在转基因的 Arabidopsis 植物被检验;仅仅叶柄和花梗被染色,没有染色在另外的纸巾被检测。Subcellular 本地化显示 GhH6L 对血浆膜并且在细胞质局部性。这些数据推进我们 GhH6L 的理解以及在棉花使功能的卓见清楚些到 GhH6L。 | Yanfeng Wu Wenliang Xu Gengqing Huang Siying Gong Juan Li Yongfang Qin Xuebao Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 1 |
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