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| 1 | 不同能量和营养浓度饲粮添加益生素对生长肥育猪生长性能、养分消化率、肉品质和血液指标的影响显示文摘本研究旨在测定添加益生素(枯草芽孢杆菌孢子和丁酸梭菌孢子混合物)以及不同能量和营养浓度对生长肥育猪生长性能、养分消化率和肉品质的影响。选择96头初始体重为(47.50±1.14)kg的生猪,试验期10周。 | Meng Q W Yan L Ao X(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 65 |
| 2 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 3 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 4 | 2001~2011年中国ST段抬高型心肌梗死(回顾性急性心肌梗死研究China PEACE):一项基于医院数据的回顾性研究显示文摘背景:尽管ST段抬高型心肌梗死十分危险,但是过去10年中国并没有国家级有代表性的研究来描述其临床特征、处理方案以及结局。 | Li J Li X Wang Q 李汭傧 | 2014 | 临床荟萃2014，29，11： | 20 |
| 5 | 中国社区健康素养与高血压治疗之间的关系:回顾性队列研究显示文摘健康素养较低与临床预后差相关。健康素养与血压之间的关系研究结果不一致。该研究调查了健康素养的决定因素和健康素养与高血压管理之间的潜在关系。方法:对360例高血压患者进行回顾性队列研究。基于标准方案进行测量、体检和实验室检查。 | 刘莉 叶鹏 Shi D Li J Wang Y Wang S Liu K Shi R Zhang Q Chen X | 2017 | 中华高血压杂志2017，25，5： | 14 |
| 6 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 7 | Measurement and Prediction of Insertion Force for the Mosquito Fascicle Penetrating into Human Skin显示文摘Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, namedfascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM),and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Directmeasurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that themosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smallerthan the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In orderto understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation isconducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between thenumerical results and the experimental measurements. | X Q Kong C W Wu | 2009 | Journal of Bionic Engineering2009，6，2： | 12 |
| 8 | Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression显示文摘 | Chen T Guo J Yang M Han C Zhang M Chen W Liu Q Wang J Cao X | 2005 | 第二军医大学学报2005，26，11： | 11 |
| 9 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 10 | Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.显示文摘 | Li X Lu F Tian Q Yang Y Wang Q Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 9 |
| 11 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 12 | 桑叶多糖对早期断奶仔猪生长性能、腹泻、血液指标和肠道菌群的影响显示文摘研究旨在探讨日粮补充桑叶多糖(MLPs)对早期断奶仔猪生长性能、腹泻、血液生化指标和肠道菌群的影响。共选取(28±2)日龄、体重为(9.18±0.46)kg的'杜洛克×长白×约克夏'杂交断奶仔猪150头,随机分成5个处理组,每组6个重复,每个重复5头猪。饮食处理如下:对照组(CT):基础日粮(BD);低剂量桑叶多糖组(LT):0.3 g·kg-1MLPs+BD;中剂量桑叶多糖组(MT):0.6 g·kg-1MLPs+BD;高剂量桑叶多糖组(HT):0.9 g·kg-1MLPs+BD;抗生素处理组(AT):0.15 g·kg-1金霉素+BD。分别在第0、10、21天的早晨,每头猪空腹测量体重并记录采食量,这些数据用来计算平均日增重(ADG)、平均日采食量(ADFI)和料重比(F/G)。每天两次(上午和下午)对每头仔猪的腹泻状况进行检查并记录。在试验结束时,收集血液样本用于生化分析,并收集盲肠、结肠和直肠内容物进行识别和量化相关的肠道菌群。研究结果表明,MLPs处理组间的日增重、平均日采食量和料重比无显著差异(P>0.05),但低剂量组(LT)、中剂量组(MT)、高剂量组(HT)的平均日采食量高于对照组(CT)和抗生素组(AT)。并且,LT、MT和HT组的料重比低于CT和AT组。与CT和AT组相比,LT、MT和HT组仔猪的腹泻发病率也显著降低(P<0.05)。生化分析表明,MLPs各处理组仔猪的血糖(GLU)水平均显著低于CT或AT组(P<0.05)。MT和HT组血液尿素氮(BUN)水平与CT和AT组存在显著差异(P<0.05),HT组T3水平显著高于CT和AT组(P<0.05)。虽然MLPs各处理组的T4水平与AT组并没有显著差异(P>0.05),但MT组的胰岛素样生长因子Ⅰ(IGF-Ⅰ)和生长激素(GH)水平较CT或AT组均显著升高(P<0.05)。LT、MT和HT 3组在抑制肠道大肠杆菌生长和促进肠道乳酸杆菌和双歧杆菌生长的整体效果上均优于CT和AT组。值得注意的是,与CT和AT组相比,HT组(0.9 g·kg-1MLPs)对抑制肠道大肠杆菌以及促进肠道有益菌群具有更显著效果(P<0.05)。结果表明,日粮添加桑叶多糖可以改善早期断奶仔猪肠道菌群的生态环境,降低腹泻率,提高整体生长性能。 | Zhao X J Lin L Luo Q L Ye M Q Luo G Q Kuang Z S | 2015 | 饲料博览2015，0，7： | 7 |
| 13 | Improvement of Fracture Toughness Lanthanum Zirconate显示文摘La2Zr2O7 (LZ) is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ (n-LZ), microcrystalline LZ (m-LZ) and LZ-5mol%8YSZ (LZ-5-8YSZ) composite (8YSZ for zirconia stabilized by 8 mol% ytrria) were studied. The n-LZ had a thermal expansion coefficient of (9.6±0.4)×10 -6 K -1 (200~1000℃) and fracture toughness of (1.98±0.07) MPa·m 1/2 which are obviously higher than those of the m-LZ ( (9.1±0.4)×10 -6 K -1 and (1.40±0.23) MPa·m 1/2, respectively), indicating that nanofication was an efficient way to increase the toughness and thermal expansion coefficient of LZ. The composite LZ-5-8YSZ had a higher fracture toughness ((1.88±0.30) MPa·m 1/2) than LZ, which was close to that of 8YSZ densified by superhigh pressure (SHP). | LI J DAI H LI Q ZHONG X H CAO X Q | 2006 | 材料工程2006，34，5： | 7 |
| 14 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 15 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 16 | 观察&等待策略与手术切除治疗新辅助放化疗后达到临床完全缓解的直肠癌患者疗效比较显示文摘背景:观察&等待策略给放化疗后达到临床完全缓解(clinical complete response,cCR)的直肠癌患者提供了非创伤性的治疗选择。本研究的目的在于分析这种策略相比手术切除的远期临床疗效。方法:研究纳入来自3个中心的接受新辅助放化疗后达到cCR的Ⅱ/Ⅲ期直肠腺癌患者。cCR的评估基于直肠指诊、结肠镜和影像学检查。接受观察&等待策略的患者与接受根治性切除术的患者按照1:1比例进行倾向评分匹配分析。采用Kaplan-Meier法分析生存情况,并采用Log-rank检验进行两组间的比较。 | 俞旻皓 WANG Q X ZHANG R XIAO W W | 2021 | 结直肠肛门外科2021，27，2： | 5 |
| 17 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 18 | Cyclic adenosine 3',5'-monophosphate induces differentiation of mouse embryonic stem cells into cardiomyocytes显示文摘 | Chen Y Shao JZ Xiang LX Guo J Zhou Q J Yao X Dai LC Lu YL | 2006 | 中国生物学文摘2006，20，7： | 5 |
| 19 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 20 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
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