|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Subclinical atherosclerosis in northern and southern China: the Chinese paradox显示文摘背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国,然而,在传统的 CHD 的差别冒险的,解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层摄影术(CT ) 在无临床症状的动脉粥样硬化检验了这些差别。我们在一个大多中心选择了参加者的一件随机的样品的方法为冠的钙在一个北城市(诺思) 里扫描的进行中的流行病的学习(北京, n = 49 ) 并且在二个南部的城市(南方) 里(上海, n = 50,并且广州, n = 50 ) 。从三个领域中心的参加者(意味着年龄 67 年) 经历了用动脉粥样硬化扫描的多种族的学习为冠的钙测量扫描的冠的风险因素评估和心脏的 CT 协议。结果调整了在诺思中国(北京) 的转变木头的冠的动脉钙 20 是 3.1 +/-0.4 并且在华南(上海和广州) 是 2.2 +/- 0.3 (P = 0.04 ) 。为北京的北城市的吝啬的钙分数比广州的南部的城市的高三倍(P = 0.01 ) 并且比为上海的南部的城市高 2.5 倍(P = 0.03 ) 。结论无临床症状的动脉粥样硬化的程度在广州和上海的二个南部的城市里比那在北京的北城市里是显著地更高的,甚至在为标准心脏的风险因素调整以后。这发现建议标准风险因素充分不在临床的 CHD 发生解释北方南方差别。 | Jie Huang Yang-Feng Wu Xiao-Qing Liu Ding Ding Lian-Cheng Zhao Bin Lu Xian Li Nathan D Wong Laurie D Dustin Stanley P Azen Robert C Detrano | 2011 | Journal of Geriatric Cardiology2011，8，2： | 7 |
| 3 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 4 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 5 | New kinematic structures for2-, 3-, 4-, and 5-DOF parallel manipulator designs显示文摘 | FengG WeiM L Xian C Z | 2002 | Mecha- nism and Machine Theory2002，37，： | 1 |
| 6 | A research on the grain growth of WC-Co cemented carbide显示文摘 | Sun L Jia C C Xian M | 2007 | Internatinal Journal of Refractory Metals and Hard Materials2007，25，： | 1 |
| 7 | Some advanced plastic processing technologies and their numerical simulation显示文摘 | Yang H Zhan M Liu Y L Xian F J Sun Z C Lin Y Zhang X G | 2004 | J Mater Process Technol2004，151，13： | 1 |
| 8 | Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling显示文摘 | Ming Leiguo Chen Keming Xian C J | 2013 | J Cell Physiol2013，228，3： | 1 |
| 9 | The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer s disease in the Han Chinese population显示文摘 | Jin C Zhang L Xian Y | 2014 | Neurosei Lett2014，563，： | 1 |
| 10 | Degradation of IGF-I in the aduh rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein显示文摘 | XIAN C J SHOUBRIDGE C A READ L C | 1996 | J Endocrinol1996，146，： | 1 |
| 11 | Compressive and flexural behavior of ultra-high - modulus polyethylene fiber and carbon fiber hybrid composites显示文摘 | Xian X J Choy C L | 1999 | Comp Sci and Technol1999，59，1： | 1 |
| 12 | Thermal, mechanical, and adhesive properties of HDPE/reactive ethyleneterpotymer blends显示文摘 | Love C T Xian G Karbhari V M | 2007 | J Appl Polym Sci2007，104，： | 1 |
| 13 | An improved variational treatment of lattice gauge theories显示文摘 | XIAN D C SONG Y X | 1985 | Phys Lett B1985，153，6： | 1 |
| 14 | Isolation and partial characterization of novel genes encoding acidic cellulases from metagenomes of buffalo rumens显示文摘 | Duan C J Xian L Zhao G C | 2009 | Journal of Applied Microbiology2009，107，： | 1 |
| 15 | hnproving enzymatic hydrolysis of wheat straw using ionic liquid 1-ethyl-3-methyl imidazolium diethyl phosphate pretreatment 显示文摘 | Li Q He Y C Xian M | 2009 | Bioresourcc Technology2009，100，： | 1 |
| 16 | On further improvement of the variational method in lattice gauge theory显示文摘 | CHEN T L XIAN D C | 1985 | Phys Lett B1985，154，： | 1 |
| 17 | Role of FGFs/FGFRs in skeletal development and bone regeneration显示文摘 | DU X XIE Y XIAN C J | 2012 | Cell Physiol2012，227，12： | 1 |
| 18 | A Bronsted acidic ionic liquid as an efficient and environmentally benign catalyst for biodiesel synthesis from free fatty acids and alcohols 显示文摘 | Zhang L Xian M He Y C | 2009 | Bioresource Technology2009，100，19： | 1 |
| 19 | Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis 显示文摘 | Xian C J Couper R Howarth GS | 2000 | Br J Cancer2000，82，4： | 1 |
| 20 | Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons 显示文摘 | Li L Xian C J Zhong JH | 2002 | Exp Neurol2002，175，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员