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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 3 | MoO_(x) and V_(2)O_(x) as hole and electron transport layers through functionalized intercalation in normal and inverted organic optoelectronic devices显示文摘To achieve fabrication and cost competitiveness in organic optoelectronic devices that include organic solar cells(OSCs)and organic light-emitting diodes(OLEDs),it is desirable to have one type of material that can simultaneously function as both the electron and hole transport layers(ETLs and HTLs)of the organic devices in all device architectures(i.e.,normal and inverted architectures).We address this issue by proposing and demonstrating Cs-intercalated metal oxides(with various Cs mole ratios)as both the ETL and HTL of an organic optoelectronic device with normal and inverted device architectures.Our results demonstrate that the new approach works well for widely used transition metal oxides of molybdenum oxide(MoOx)and vanadium oxide(V_(2)O_(x)).Moreover,the Cs-intercalated metaloxide-based ETL and HTL can be easily formed under the conditions of a room temperature,water-free and solution-based process.These conditions favor practical applications of OSCs and OLEDs.Notably,with the analyses of the Kelvin Probe System,our approach of Cs-intercalated metal oxides with a wide mole ratio range of transition metals(Mo or V)/Cs from 1:0 to 1:0.75 can offer significant and continuous work function tuning as large as 1.31 eV for functioning as both an ETL and HTL.Consequently,our method of intercalated metal oxides can contribute to the emerging large-scale and low-cost organic optoelectronic devices. | Xinchen Li Fengxian Xie Shaoqing Zhang Jianhui Hou Wallace CH Choy | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 4 | A CONVENIENT AND EFFICIENT SYNTHESIS OF BIS-IMIDAZOLES显示文摘ACONVENIENTANDEFFICIENTSYNTHESISOFBIS-IMIDAZOLES￥ChengHeZHOU;ShengJinGUO;RuGangXIE,HuaMingZHAO(DepartmentofChemistry.Facultyo... | Zhou, CH Guo, SJ Xie, RG Zhao, HM | 1996 | Chinese Chemical Letters1996，7，4： | 2 |
| 5 | Application of a visible simulation surgery technique in preoperation planning for intahepatic calculi显示文摘 | Fang CH Xie AW Chen ML | 2010 | World J Surg2010，34，： | 1 |
| 6 | Application of Box Behnken design in optimization for polysaccharides extraction from cultured mycelium of Cordyceps sinensis显示文摘 | Dong CH Xie X Q Wang X L | 2009 | Food Bioprod Process2009，87，2： | 1 |
| 7 | Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel显示文摘 | Xie J Wang CH | | 0，，12： | 1 |
| 8 | Molecular modeling, design, synthesis, and biological evaluation of novel 3', 4'-dicamphanoyl-( + ) -cis-khellactone (DCK) analogs as potent anti-HIV agents 显示文摘 | Xie L Zhao CH Zhou T | 2005 | Bioorg Med Chem2005，13，： | 1 |
| 9 | Evaluation of the prognostic value and functional roles of CD44v6 in gastric cancer 显示文摘 | Xie JW Chen PC Zheng CH | 2015 | J Cancer Res Clin 0ncol2015，141，10： | 1 |
| 10 | Application of a visible simulation surgery teehnique in preoperation planning for intrahepatie caieuli 显示文摘 | Fang CH Xie AW Chen ML | 2010 | World J Surg2010，34，2： | 1 |
| 11 | Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor cone-jet mode 显示文摘 | Xie J Wang CH | 2007 | Biotechnol Bioeng2007，97，5： | 1 |
| 12 | Application of a visible simulation surgery technique in preoperation planning for intrahepatic calculi显示文摘 | Fang CH Xie AW Chen ML | | 0，，： | 1 |
| 13 | MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel-induced multidrug resistance显示文摘 | Dai Y Xie CH Neis JP | | 0，，05： | 1 |
| 14 | MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel-induced muhidrug resistance 显示文摘 | Dai Y Xie CH Neis JP | 2011 | Head Neck2011，33，6： | 1 |
| 15 | Transcriptome of Escherichia coil K1 bound to human brain microvascular endothelial ceils 显示文摘 | Xie Y Parthasarathy G Di Cello F Teng CH Paul-Satyaseela M Kim KS | 2008 | Biochem Biophys Res Commun2008，365，1： | 1 |
| 16 | The production and charachteristics of solid lipid nanoparticles 显示文摘 | Hou DZ Xie CS Zhu CH | 2003 | Biomaterials2003，24，5： | 1 |
| 17 | Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor cone-jet mode显示文摘 | Xie J Wang CH | 2007 | Biotechnol Bioeng2007，97，5： | 1 |
| 18 | Influence of citric acid treatment on the surface acid properties of zeolite beta 显示文摘 | Xie Z K Chen Q L Zhang Ch F | 2000 | The Journal of Physical Chemistry B2000，104，13： | 1 |
| 19 | Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats : possible involvement of TLR4/NF-k B-mediated inflammatory pathway 显示文摘 | Wang CX Xie GB Zhou CH | 2015 | Brain Res2015，1594，： | 1 |
| 20 | Hydrodesulfurization performance of an ex-situ presulfided MoNiP/γ-Al2O3 hydrotreating catalyst显示文摘 | Li Y P Xie H F Liu Ch G | 2005 | Prepr Pap-Am Chem Soc Div Pet Chem2005，50，1： | 1 |
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