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| 1 | Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations显示文摘 | Juliette Foucher Laurent Castéra Pierre-Henri Bernard Xavier Adhoute David Laharie Julien Bertet Patrice Couzigou Victor de Lédinghen | 2006 | European Journal of Gastroenterology & Hepatology2006，，4： | 3 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Management of carotid ar- tery Enosis; comparing endarterectomy and satining 显示文摘 | Hartal RA Xavier AR Ki mani JF ethal | 2013 | Car cardi- nal Rep2013，5，： | 1 |
| 4 | Management of carotidarterystenosis:comparing endarterectomy and stentmg显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curt Cardiol Rep2003，5，2： | 1 |
| 5 | Raman s Pectrosco Py detection of molecular changes associated with two ex Perimental models of osteoarthritis in rats显示文摘 | De Souza RA Xavier M Mangueira NM | 2014 | Lasers Med Sci2014，29，2： | 1 |
| 6 | Management of carotidarterystenosis:comparing endarterectomy and stentmg显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Cardiol Rep2003，5，2： | 1 |
| 7 | Management of carotidar_tenosis:comparing endarterectomg and stenting 显示文摘 | Hanel RA Xavier AR Kimani JF? | 2003 | CurtCardiol Rep2003，5，： | 1 |
| 8 | Management of carotid artery stenosis: comparing endarterectomy and stenting 显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，2： | 1 |
| 9 | Management of carotid artery stenosis: comparing endarterectomy and stenting 显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，： | 1 |
| 10 | Management of carotid artery atenosis:comparing end-arterectomv and stenting显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，： | 1 |
| 11 | Management of carotid arterystenosis: Comparing endarterectomy and stenting 显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，： | 1 |
| 12 | Neonatal candidemia in a public hospital in MatoGrosso do Sul显示文摘 | Xavier PC Chang MR Nunes MO Palhares DB Silva RA Bon-fim GF | 2008 | Rev Soc Bras Med Trop2008，41，5： | 1 |
| 13 | Management of carotid artery stenosis: comparing endarterectomy and stenting显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，： | 1 |
| 14 | Management of carotidar - tenosis : comparing endarterectomg and stenting 显示文摘 | Hanel RA Xavier AR Kimani JF | 2003 | Curt Cardiol Rep2003，5，： | 1 |
| 15 | Management of carotid arterystenosis:Comparing endarterectomy and stenting显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，2： | 1 |
| 16 | Outcome following intracerebral hemorrhage and subaraehnoid hemorrhage显示文摘 | Hanel RA Xavier AR Mohammad Y | 2002 | Neu- rol Res2002，24，1： | 1 |
| 17 | Management of ca- rotid artery stenosis: comparing endarterectomy and stenting 显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Curr Cardiol Rep2003，5，： | 1 |
| 18 | Outcome following intracerebral hemorrhage and subarachnoid hemorrhag显示文摘 | Hanel RA Xavier Ar MY | 2002 | Neurol Res2002，24，11： | 1 |
| 19 | Management of carotid arter- y stenosis: comparing endarterectomy and stenting显示文摘 | Hanel RA Xavier AR Kirmani JF | 2003 | Stroke2003，5，2： | 1 |
| 20 | Management of carotid artery stenosis:comparingend arterectony and stenting显示文摘 | Xavier AR Kirmani JF etal | 2003 | CurrCardiolRep2003，5，2： | 1 |
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