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| 1 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 2 | Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice显示文摘BackgroundHyperhomocysteine 是冠的心疾病(CHD ) 的一个独立风险因素。然而, hyperhomocysteine 是否影响动脉粥样硬化的前进,是不清楚的。在现在的学习,我们在低密度的脂蛋白在动脉粥样硬化的形成上检验了 hyperhomocysteine 的效果受体缺乏(LDLr −/−) mice.MethodsForty -- 八只 7-week-old LDLr −/− 老鼠被分到下列组:老鼠喂了一本标准啮齿类动物食谱(控制组) ,老鼠喂了一本高蛋氨酸的食谱(高蛋氨酸的组) ,老鼠喂了一本高脂肪的食谱(高脂肪的组) ,并且老鼠在蛋氨酸和脂肪(高蛋氨酸、高脂肪的组) 高喂了一本食谱。在 19, 23,和 27 个星期岁时,在在每个组的每间隔的四个鼠标是 sacrificed.ResultsAt 学习的结束,鼠标没在大动脉的湾穴和大动脉的表面显示出动脉粥样硬化患者损害直到在控制组旧的 27 个星期。然而,动脉粥样硬化患者损害在 19 个星期在另外的三个组发展了。大动脉的表面上的动脉粥样硬化患者损害的数量比在高脂肪的组在高蛋氨酸的组是更低的(P <0.001 ) 。在高蛋氨酸、高脂肪的组的大动脉的表面上的动脉粥样硬化患者损害是最严重的。在大动脉的湾穴的动脉粥样硬化患者损害的吝啬的区域比在高脂肪的组在高蛋氨酸的组与大动脉的表面上的动脉粥样硬化患者损害相比是更低的(P <0.001 ) 。在在高蛋氨酸、高脂肪的组的大动脉的湾穴的动脉粥样硬化患者损害是大多数 severe.ConclusionsHomocysteinemia 加速动脉粥样硬化患者损害并且在 LDLr −/− 老鼠独立地导致早动脉粥样硬化。减少 homocysteinemia 的水平可能为 CHD 的预防和处理是有益的。 | Hang-Yuan GUO Fu-Kang XU Hai-Tao LV Long-Bin LIU Zheng JI Xiao-Ya ZHAI Wei-Liang TANG Ju-Fang CH | 2014 | Journal of Geriatric Cardiology2014，11，1： | 23 |
| 3 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 4 | Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance显示文摘有非小的房间肺癌症(NSCLC ) 的最对待 gefitinib 的病人将最后开发抵抗。从 LC Hemsl 的 Lysimachia capillipes (LC ) capilliposide 摘录。在 vitro 并且在 vivo 反癌症效果出现。在这研究,我们调查了在有 gefitinib 的联合的 LC capilliposide 是否能克服 NSCLC 房间的抵抗到 gefitinib 并且识别包含的发信号的小径。有 LC capilliposide 的治疗独自禁止了 NSCLC 房间线(PC-9, H460, H1975, H1299 和 PC-9-GR ) 的一块面板的生长对有在 g/mL 的范围的 IC 50 价值的 gefitinib 敏感或抵抗。在 gefitinib 抵抗的 PC-9-GR 房间(它有一个 T790M EGFR 变化) , LC capilliposide (在 IC30, i.e.1.2 g/mL ) 显著地与它的 IC50 价值提高了 gefitinib 的禁止的效果从 6.80 | Shi-rong ZHANG Ya-si XU Er JIN Lu-cheng ZHU Bing XIA Xu-feng CH EN Fan-zhu LI Sheng-lin MA | 2017 | Acta Pharmacologica Sinica2017，38，1： | 7 |
| 5 | Dynamics of electrodeposition of tetraethylthioram disulphide(TETD) on pyrite surface显示文摘The electrode process of pyrite in diethyldithiocarbamate (DDTC) solution pH 11.4 was investigated by using cyclic voltammetry, potentiost atic and chronopotentiometry. Tetraethylthioram disulphide(TETD) was electrodepo sited on pyrite electrode surface as the electrode potential is higher than 0.2 V. The relationship of the current density caused by diffusion and reaction time can be ascertained as i =1/(9.08×10 -5 +4.77×10 -3 t 0.5 ) , and the diffusion coefficient of DDTC on pyrite surface is about 3.72×10 - 6 cm 2/s. At pH 11.4, the thickness of TETD adsorbed on pyr ite surface is about 1.63 molecule layer. The electrochemical dynamics equation of the reduction of TETD on pyrite surface is given as η =0.116-0.064log[1- ( t/τ ) 0.5 ]. The kinetic parameters were determined as follows: the ex change current density ( i 0) is 3.08 μA/cm 2; the transmission coeffi cient( α ) is 0.462. | QIN Wen-qing,QIU Guan-zhou,HU Yue-hua,XU Jing (Department of Mineral Enginering, Central South University, Changsha 410083, Ch ina) | 2001 | Journal of Central South University2001，13，3： | 5 |
| 6 | Contour representation based on wedgelet显示文摘Aiming at the shortcomings of the existing wed gelet compression arithmetics, a novel contour-representing algorithm based on wedgelets is presented in this paper. Firstly the input image is binarized and the most optimized wedgelets ar e found by means of quadtree framework. Then the contours are reconstructed by a pplying the wedgelets, the data volume is compressed, and the shortcomings of th e contour representation based on normal wavelet are ameliorated, the better ef fect for the visualization is obtained, too. | Liu Zeyi~1, Sun Ziqiang~ 2,3 , Xu Ling~2 & Peng Xiang~ 4,5 1. Dept. of Mathematics of Science Coll., Shenzhen Univ., Shenzhen 518060, P.R. China 2. Dept. of Mathematics of Science Coll., Tianjin Univ., Tianjin 300072, P.R. Ch ina 3.Tianjin Foreign Studies Univ., Tianjin 300204, P.R. China 4. Inst. of Optoelectronics, Shenzhen Univ., Shenzhen 518060, P.R. China 5. National Lab of Precision Measurement Technology and Instrumentation, Tianjin 300072, P.R. China | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 2 |
| 7 | Synthesis of Polycaprolactone with Two Carboxyl End Groups显示文摘At 225℃. caprolactone has been polymerized in the presence of succinic acid under dry nitrogen atmosphere. Characterizations of the polymer through IR and molecular weight measurements by 1H-NMR and end group titration have shown that the polycaprolactone obtained is of two carboxyl end groups. The molecular weight of it increases with decreasing of the acid content in the reaction mixture under the same polymerization conditions. With a certain ratio of acid to caprolactone. the maximum of molecular weight of the polymer will be reached at the reaction time of 3h. | Qijin ZHANG Wenying XU and Zhiyong WANG (Dept. of Mater. Sci. & Eng., University of Science and Technology of China, Hefei, 230026, China)(To whom correspondence should be addressed)(Dept. of Modern Chemistry, University of Science and Technology of Ch | 1994 | Journal of Materials Science & Technology1994，10，5： | 2 |
| 8 | Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice显示文摘 | Xu CF Yu CH Li YM | 2009 | OMICS2009，13，6： | 1 |
| 9 | Cyclic tensile strain acts as an antagonist of IL-1β actions in Chondrocytes 显示文摘 | Xu Zhongfa Buckley MJ Evans CH | 2000 | The Journal of Immunology2000，165，： | 1 |
| 10 | Continuous-wave mode- locked Ti: sapphire laser focusable to 5 3 1013 Wycm2显示文摘 | Xu L Tempea G Spielmann Ch | 1998 | Opt Lett1998，23，10： | 1 |
| 11 | A cytosolic class I small heat shock protein,RcLEA,of Rosa chinensis confers resistance to a variety of stresses to Escherichia coli,yeast and Arabidopsis thaliana显示文摘 | JIANG CH XU JY ZHANG H | 2009 | Plant Cell and Environment2009，32，： | 1 |
| 12 | Use of response surface methodology to optimize the hydrolysis of whey protein isolate显示文摘 | Chesion S Ch Wang Zh Xu S Y | 2007 | Journal of Food Engineering2007，80，4： | 1 |
| 13 | Prognostic significance of osteopontin in hepatocellular carcinoma, a meta-analysis 显示文摘 | ZHANG CH XU GL JIA WD | 2012 | Int J Cancer2012，130，： | 1 |
| 14 | A simple memristor chaotic circuit with complex dynamics显示文摘 | BAO B CH MA Z XU J P | 2011 | International Journal of Bifurcation and Chaos2011，21，9： | 1 |
| 15 | Analysis for load limitation of square-shaped silicon diaphragms显示文摘 | ZHAO LL XU CH SHEN G G | | 0，，50： | 1 |
| 16 | Analysis and identification of different animal horns by a three-stage infrared spectroscopy, Spectrochim acta part a-mol ecular and biomolecular spectroscopy显示文摘 | Wang Y Xu CH Wang P | 2011 | 83(1): 265-2702011，83，1： | 1 |
| 17 | Vocalacrobatics in a Chinese frog,Amolops tormotus显示文摘 | Feng AS PM Narins CH Xu | 2002 | Naturwissenschaften2002，89，： | 1 |
| 18 | Steady periodic memristor oscillator with transient chaotic behaviours显示文摘 | BAO B CH LIU Z XU J P | 2010 | Electronics letters2010，46，3： | 1 |
| 19 | Equivalence Analysis of Accuracy of Geolocation Models for Spaceborne InSAR 显示文摘 | XU H P KANG CH H | 2010 | IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING2010，48，1： | 1 |
| 20 | Ultrasonic communicationin frogs显示文摘 | Feng AS PM Narins CH Xu WY Lin ZL Yu Q Qiu ZM Xu and JX Shen | 2006 | Nature2006，440，： | 1 |
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