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| 1 | Oxidative stress in alcohol-related liver disease显示文摘Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs.Heavy alcohol misuse leads to alcohol-related liver disease,which is responsible for a significant proportion of alcohol-attributable deaths globally.Other than reducing alcohol consumption,there are currently no effective treatments for alcohol-related liver disease.Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants.It plays important roles in several aspects of alcohol-related liver disease pathogenesis.Here,we review how chronic alcohol use results in oxidative stress through increased metabolism via the cytochrome P4502E1 system producing reactive oxygen species,acetaldehyde and protein and DNA adducts.These trigger inflammatory signaling pathways within the liver leading to expression of pro-inflammatory mediators causing hepatocyte apoptosis and necrosis.Reactive oxygen species exposure also results in mitochondrial stress within hepatocytes causing structural and functional dysregulation of mitochondria and upregulating apoptotic signaling.There is also evidence that oxidative stress as well as the direct effect of alcohol influences epigenetic regulation.Increased global histone methylation and acetylation and specific histone acetylation inhibits antioxidant responses and promotes expression of key pro-inflammatory genes.This review highlights aspects of the role of oxidative stress in disease pathogenesis that warrant further study including mitochondrial stress and epigenetic regulation.Improved understanding of these processes may identify novel targets for therapy. | Huey K Tan Euan Yates Kristen Lilly Ashwin D Dhanda | 2020 | World Journal of Hepatology2020，12，7： | 6 |
| 2 | Effect of Surface Tarp on Emissions and Distribution of Drip-applied Fumigants显示文摘 | PAPIERNIK S K YATES S R DUNGAN R S | 2004 | Environ Sci Technol2004，38，16： | 1 |
| 3 | A 'high-pressure' electron spectrometer for surface studies 显示文摘 | Joyner R W Roberts M W Yates K | 1979 | Surface Science1979，87，： | 1 |
| 4 | Wound chronicity, inpatient care, and chro- nic kidney disease predispose to MRSA inection in diabetic foot ulcers显示文摘 | Yates C May K | 2009 | Diabetes care2009，32，10： | 1 |
| 5 | Mycobacterium tuberculosis and the environment within the phagosome显示文摘 | Rohde K Yates RM Purdy GE Russell DG | 2007 | Immunol Rev2007，219，： | 1 |
| 6 | Volatile flavour constituents in the skin oil from Feijoa sellowiana显示文摘 | Shaw G J Allen J M Yates M K | 1989 | Phytochernistry1989，28，5： | 1 |
| 7 | International standards and construction 显示文摘 | Yates J K Aniftos S | 1997 | Journal of Construction Engineering and Management ASCE1997，123，2： | 1 |
| 8 | Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide显示文摘 | Thimmulappa RK Scollick C Traore K Yates M Trush MA Liby KT | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 9 | Effect of Math Self-Concept,Perceived Self-Efficacy,and Contributions for Failure and Success on Test Anxiety显示文摘 | Bandalos D L Yates K Thormdike-chrisl T | 1995 | Journal of Educational Psychology1995，87，4： | 1 |
| 10 | The quadrupole ion trap mass spectrometer-a small solution to a big challenge显示文摘 | Jonscher K R Yates J R | 1997 | Anal Biochem1997，，244： | 1 |
| 11 | Complement C3 variant and the risk of age-related macular degeneration显示文摘 | Yates J R Sepp T Matharu B K | 2007 | N Engl J Med2007，357，6： | 1 |
| 12 | In vivo effects of human recombinant TGF-β on bone turnover in normal mice显示文摘 | Marcellic Yates K Mundy G | 1996 | J Bone Miner Res1996，，5： | 1 |
| 13 | Continuous glucose monitoring-guided insulin adjustment in children and adolescents on near-physiological insulin regimens: a randomized controlled trial 显示文摘 | Yates K Hasnat Milton A Dear K | 2006 | Diabetes Care2006，29，7： | 1 |
| 14 | 显示文摘 | YATES R S STENSTROM M K | 1993 | Amr Water Works Assoc Annual Proceeding San Antonio1993，，： | 1 |
| 15 | Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease显示文摘 | Patton HM Yates K Unalp-Arida A | | 0，，： | 1 |
| 16 | Bromate Production in Ozone Contactors 显示文摘 | YATES P S and STENSTROM M K | 1993 | AWWA Annual Conference Proceedings San Antonio TX1993，，： | 1 |
| 17 | Photocatalytic Oxidation of 2-Chloroethyl Ethyl Sulfide on TiO2/SiO2 Powders显示文摘 | Panayotov D A Paul D K Jr Yates J T | 2003 | J Phys Chem B2003，107，10： | 1 |
| 18 | Cerebral microbleeds:a review of clinical,genetic,and neuroimaging associations显示文摘 | YATES P A VILLEMAGNE V L ELLIS K A | 2014 | Frontiers in Neurology2014，4，： | 1 |
| 19 | Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus显示文摘 | Yates K M Rosenberg L J Harris C K | 1992 | Vet Immunol Immunopathol1992，35，12： | 1 |
| 20 | Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volounteers显示文摘 | Yates R Nairn K Dixon R | 2002 | J Clin Pharmacol2002，42，11： | 1 |
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