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| 1 | Hepatitis E virus infection: Epidemiology and treatment implications显示文摘Hepatitis E virus(HEV) infection is now established as an emerging enteric viral hepatitis. Standard treatments in acute and chronic hepatitis E remain to be established. This study undertakes a review of the epidemiology, treatment implication and vaccine prevention from published literature. HEV infection is a worldwide public health problem and can cause acute and chronic hepatitis E. HEV genotypes 1 and 2 are primarily found in developing countries due to waterborne transmission, while the zoonotic potential of genotypes 3 and 4 affects mostly industrialized countries. An awareness of HEV transmission through blood donation, especially in the immunocompromised and solid organ transplant patients, merits an effective anti-viral therapy. There are currently no clear indications for the treatment of acute hepatitis E. Despite concerns for side effects, ribavirin monotherapy or in combination with pegylatedinterferon alpha for at least 3 mo appeared to show significant efficacy in the treatment of chronic hepatitis E. However, there are no available treatment options for specific patient population groups, such as women who are pregnant. Vaccination and screening of HEV in blood donors are currently a global priority in managing infection. New strategies for the treatment and control of hepatitis E are required for both acute and chronic infections, such as prophylactic use of medications, controlling large outbreaks, and finding acceptable antiviral therapy for pregnant women and other patient groups for whom the current options of treatment are not viable. | Ga Young Lee Kittiyod Poovorawan Duangnapa Intharasongkroh Pattaratida Sa-nguanmoo Sompong Vongpunsawad Chintana Chirathaworn Yong Poovorawan | 2015 | World Journal of Virology2015，4，4： | 5 |
| 2 | Apoptotic signaling through reactive oxygen species in cancer cells显示文摘Reactive oxygen species(ROS) take part in diverse biological processes like cell growth,programmed cell death,cell senescence,and maintenance of the transformed state through regulation of signal transduction. Cancer cells adapt to new higher ROS circumstance. Sometimes,ROS induce cancer cell proliferation. Meanwhile,elevated ROS render cancer cells vulnerable to oxidative stress-induced cell death. However,this prominent character of cancer cells allows acquiring a resistance to oxidative stress conditions relative to normal cells. Activated signaling pathways that increase the level of intracellular ROS in cancer cells not only render up-regulation of several genes involved in cellular proliferation and evasion of apoptosis but also cause cancer cells and cancer stem cells to develop a high metabolic rate. In over the past several decades,many studies have indicated that ROS play a critical role as the secondary messenger of tumorigenesis and metastasis in cancer from both in vitro and in vivo. Here we summarize the role of ROS and anti-oxidants in contributing to or preventing cancer. In addition,we review the activated signaling pathways that make cancer cells susceptible to death. | Daejin Kim Ga Bin Park Dae Young Hur | 2014 | World Journal of Immunology2014，4，3： | 2 |
| 3 | Increased plasma leptin/fat ration in patients with chronic renal failure:a cause of malnutrition显示文摘 | Young GA Woodrow G Kendall S | 1997 | Nephrol Dial Transplant1997，12，11： | 1 |
| 4 | Nutritional assessment of continous ambulatory peritoneal dialysis patients:an international study显示文摘 | Young GA Kopple JD Lindholm B | 1991 | Am J Kidney Dis1991，17，4： | 1 |
| 5 | Transformation and transfection in lysogenic strains of Bacillus subtilis: Evidence for selection induction of prophage in competent cells 显示文摘 | Yasbin RE Wilson GA Young FE | 1975 | JBacteriol1975，121，： | 1 |
| 6 | Nutritional assess ment of continuous ambulatory peritoneal dialysis patients:an international study显示文摘 | Young GA Kopple JD Lindholm B | 1991 | Am J Kidney Dis1991，17，： | 1 |
| 7 | Intensified induction chemotherapy with high dose cytarabine and etoposide for acute myeloid leukemia:a review and update results of the Australian Leukemia Study Group显示文摘 | Bioshop JF Matthews JP Young GA | 1998 | Leuk Lymphoma1998，28，3： | 1 |
| 8 | The influence of patlent-and facility - specific factors on nutritional status and survival in hemodialysis显示文摘 | Kaysen GA Muller HG Young BS | 2004 | J Ren Nutr2004，142，： | 1 |
| 9 | Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients 显示文摘 | Marmarou A Young HF Aygok GA | 2005 | J Neurosurg2005，102，6： | 1 |
| 10 | Long non-coding RNA HOTAIR is associated with human cervical cancerprogression显示文摘 | Hee Kim Dae Lee Ga Yim Eun Nam Sunghoon Kim Sang Kim Young Kim | 2015 | International Journal of Oncology2015，，： | 1 |
| 11 | Gene therapy strategies for colon cancer 显示文摘 | Chung-Faye GA Kerr DJ Young LS | 2000 | Mol Med Today2000，6，2： | 1 |
| 12 | Transluminal extraction catheter atherectomy followed by immediate stenting in treatment of saphenous vein grafts显示文摘 | Xenopoulos NP Young T | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 13 | Nutritional assessment of continuous ambulatory peritoneal dialysis patients : An international study显示文摘 | Young GA Kopple JD Lindholm B | 1991 | Am J Kidney Dis1991，17，： | 1 |
| 14 | Nutritional assessment of continuous ambulatory peritoneal dialysis patients: an international study显示文摘 | Young GA Kopple JD Lindholm B | 1991 | Am J Kidney Dis1991，17，： | 1 |
| 15 | A randomized study of high-dose cytarabine in induction in acute myeloid leukemia 显示文摘 | Bishop JF Matthews JP Young GA | 1996 | Blood1996，87，5： | 1 |
| 16 | Diagnosis and management of idiopathic normal-pressure hydrocephalus:a prospective study in 151 patients显示文摘 | Marmarou A Young HF Aygok GA | 2005 | J Neurosurg2005，102，6： | 1 |
| 17 | Thrombophilia and the risk for hemodialysis vascular access thrombosis显示文摘 | Knoll GA Wells PS Young D | 2005 | J Am Soc Nephrol2005，16，4： | 1 |
| 18 | Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? 显示文摘 | Young GA Woodrow G Kendall S | 1997 | Nephnol Dial Transplant1997，12，11： | 1 |
| 19 | Maternal serum triglycerides as predictive factors for large‐for‐gestational age newborns in women with gestational diabetes mellitus显示文摘 | GA HYUNSON JA YOUNGKWON YOUNG HANKIM YONG WONPARK | 2010 | Acta Obstetricia et Gynecologica Scandinavica2010，，5： | 1 |
| 20 | Nutritional assessment of continuous ambulatory peritoneal dialysis patients: an international study显示文摘 | Young GA Kopple JD Lindholm B | 1991 | Am J Kidney Dis1991，17，： | 1 |
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