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| 1 | Effect of Deformation Temperature on Microstructure and Mechanical Properties of AZ31 Mg Alloy Processed by Differential-Speed Rolling显示文摘A differential-speed rolling(DSR) was applied to AZ31 magnesium alloy sample at different rolling temperatures of 473,523,573,and 623 K with 1-pass and 2-pass operations.The microstructural evolution and mechanical properties of the deformed samples were investigated.The rolling temperature was found to be an important parameter affecting the microstructural development.After DSR at 473 K,the microstructure was more homogeneous than that obtained after deformation by equal-speed rolling(ESR).The fully recrystallized microstructures were generated after DSR at 573 and 623 K.As to mechanical properties,the yield strength(YS) and ultimate tensile strength(UTS) decreased monotonously with increasing rolling temperature.In contrast,the elongation of the DSR-deformed samples was improved as the rolling temperature increased.The strain hardening exponent(n) calculated by Hollomon equation increased with increasing the rolling temperature,which would explain an increase in the uniform elongation. | Mosab Kaseem Bong Kwon Chung Hae Woong Yang Kotiba Hamad Young Gun Ko | 2015 | Journal of Materials Science & Technology2015，31，5： | 19 |
| 2 | Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-a显示文摘AIM: To determine whether Lactobacillus plantarum can modify the deleterious effects of tumor necrosis factor-a (TNF-a) on intestinal epithelial cells. METHODS: Caco-2 cells were incubated with TNF-a alone or in the presence of L. plantarum. Transepithelial electrical resistance was used to measure epithelial barrier function. Interleukin 8 (IL-8) secretion by intestinal epithelial cells was measured using an ELISA. Cellular lysate proteins were immunoblotted using the anti-extracellular regulated kinase (ERK), anti-phospho- ERK and anti-IκB-a. RESULTS: A TNF-a-induced decrease in transepithelial electrical resistance was inhibited by L. plantarum. TNF- a-induced IL-8 secretion was reduced by L. plantarum. L. plantarum inhibited the activation of ERK and the degradation of IκB-a in TNF-a-treated Caco-2 cells. CONCLUSION: Induction of epithelial barrier dysfunction and IL-8 secretion by TNF-a is inhibited by L. plantarum. Probiotics may preserve epithelial barrier function and inhibit the inflammatory response by altering the signal transduction pathway. | Jae Sung Ko Hye Ran Yang Ju Young Chang Jeong Kee Seo | 2007 | World Journal of Gastroenterology2007，13，13： | 18 |
| 3 | Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease显示文摘AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each patient.The aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were calculated.RESULTS:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant fibrosis.Among noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD. | Hye Ran Yang Hae Ryoung Kim Myung Jin Kim Jae Sung Ko Jeong Kee Seo | 2012 | World Journal of Gastroenterology2012，18，13： | 15 |
| 4 | Genetically confirmed Wilson disease in a 9-month old boy with elevations of aminotransferases显示文摘Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by alteration of the adenosine triphosphatase 7B gene. It is rare to diagnose WD below the age of three years. Molecular genetic testing is one of the most important diagnostic methods and may confirm the diagnosis in equivocal cases. We report a case of a 9-mo old boy with WD who presented as chronic hepatitis. Genetic analysis showed compound heterozygotes of p.G1186S and c.4006delA. | Joo Whee Kim Jong Hyun Kim Jeong Kee Seo Jae Sung Ko Ju Young Chang Hye Ran Yang Kyung Hoon Kang | 2013 | World Journal of Hepatology2013，5，3： | 11 |
| 5 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 6 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 7 | Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors显示文摘Aim: Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor (GLP-1). The aim of this study was to investigate whether sitagliptin protected the kidney function from acute ischemia-reperfusion (IR) injury in rats. Methods: Adult male SD rats were categorized into 4 groups: sham control, IR injury, IR+sitagliptin (300 mg/kg) and IR+sitagliptin (600 mg/kg). Acute renal IR injury of both kidneys was induced by clamping the renal pedicles for I h. The drug was orally administered at 1, 24 and 48 h after acute IR. Blood samples and 24-h urine were collected before and at 72 h after acute IR. Then the rats were sacrificed, and the kidneys were harvested for biochemical and immunohistochemical studies. | Meng-wei CHANG Chih-hung CHEN Yi-ching CHEN Yin-chun WU Yen-yi ZHEN Steve LEU Tzu-hsien TSAI Sheung-fat KO Pei-hsun SUNG Chih-chau YANG Hsin-ju CHIANG Hsueh-wen CHANG Yen-ta CHEN Hon-kan YIP | 2015 | Acta Pharmacologica Sinica2015，36，1： | 6 |
| 8 | Inhibitory effect of different Dendrobium species on LPS-induced inflammation in macrophages via suppression of MAPK pathways显示文摘Dendrobii Caulis(DC), named ‘Shihu' in Chinese, is a precious herb in traditional Chinese medicine. It is widely used to nourish stomach, enhance body fluid production, tonify 'Yin' and reduce heat. More than thirty Dendrobium species are used as folk medicine. Some compounds from DC exhibit inhibitory effects on macrophage inflammation. In the present study, we compared the anti-inflammatory effects among eight Dendrobium species. The results provided evidences to support Dendrobium as folk medicine, which exerted its medicinal function partially by its inhibitory effects on inflammation. To investigate the anti-inflammatory effect of Dendrobium species, mouse macrophage cell line RAW264.7 was activated by lipopolysaccharide. The nitric oxide(NO) level was measured using Griess reagent while the pro-inflammatory cytokines were tested by ELISA. The protein expressions of inducible NO synthase(iNOS), cyclooxygenase-2(COX-2) and mitogen-activated protein kinases(MAPKs) phosphorylation were evaluated by Western blotting analysis. Among the eight Dendrobium species, both water extracts of D. thyrsiflorum B.S.Williams(DTW) and D. chrysotoxum Lindl(DCHW) showed most significant inhibitory effects on NO production in a concentration-dependent manner. DTW also significantly reduced TNF-α, MCP-1, and IL-6 production. Further investigations showed that DTW suppressed iNOS and COX-2 expression as well as ERK and JNK phosphorylation, suggesting that the inhibitory effects of DTW on LPS-induced macrophage inflammation was through the suppression of MAPK pathways. In conclusion, D. thyrsiflorum B.S.Williams was demonstrated to have potential to be used as alternative or adjuvant therapy for inflammation. | ZENG Qiang Chun-Hay Ko Wing-Sum Siu LI Kai-Kai Chun-Wai Wong HAN Xiao-Qiang YANG Liu Clara Bik-San Lau HU Jiang-Miao Ping-Chung Leung | 2018 | Chinese Journal of Natural Medicines2018，16，7： | 4 |
| 9 | Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms显示文摘BACKGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory properties.Although human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive collection.AIM To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and BM-MSCs.METHODS To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γalone.Activated T cells were cocultured with MSCs treated with indomethacin and/or anti-IL-10.To assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or anti-IL-10.Xenogeneic graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell therapies.RESULTS Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation abilities.BM-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γalone.UC-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory environment.Cyclooxygenase-2 and IL-10 were key factors in the immunomodulatory mechanisms of both MSCs.In addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than BM-MSCs.UC-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host disease.CONCLUSION UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms involved.These findings suggest that UC-MSCs have distinct immunoregulatory functions and may substitute BM-MBSCs in the field of cell therapy. | Yunejin Song Jung-Yeon Lim Taekyu Lim Keon-Il Im Nayoun Kim Young-Sun Nam Young-Woo Jeon Jong Chul Shin Hyun Sun Ko In Yang Park Seok-Goo Cho | 2020 | World Journal of Stem Cells2020，12，9： | 4 |
| 10 | 一种新型六角形编织机器的构建与应用显示文摘文章首先简单地回顾了传统编织技术,然后阐述新型的六角形编织基本原理,并从编织运动实现原理以及编织控制方面详细讲述基于Labview计算机控制的六角形编织机器的构建方法。最后,通过举例方式展示这种六角形编织的初步应用。可以看出,这种新颖的六角形编织机器的开发,对未来利用精细化微观编织产品的新兴领域来说具有重大意义。 | 高彦涛 Frank Ko Heejae Yang 胡红 | 2013 | 纺织导报2013，，4： | 3 |
| 11 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 12 | Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study显示文摘BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor prognosis.However,data regarding risk factors and survival outcomes of early EHR after surgical resection remain scarce.AIM To investigate the clinical features and risk factors of early EHR and elucidate its association with survival outcomes.METHODS From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic centers.After excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 patients.Surgical resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected patients.Multivariate Cox regression analysis was performed to identify the variables associated with EHR.RESULTS Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 years.The recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early EHR.In 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical resection.On multivariate analysis,serum albumin<4.0 g/dL,serum alkaline phosphatase>100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early EHR.After sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early EHR.Furthermore,multivariate analysis revealed that early EHR was associated with substantially worse survival outcomes(Hazard ratio,6.77;95%confidence interval,4.81-9.52;P<0.001).CONCLUSION Early EHR significantly deteriorates the survival of patients with HCC,and our identified risk factors may predict the clinical outcomes and aid in postoperative strategies for improving survival. | Jae Hyun Yoon Sung Kyu Choi Sung Bum Cho Hee Joon Kim Yang Seok Ko Chung Hwan Jun | 2022 | World Journal of Gastroenterology2022，28，36： | 2 |
| 13 | Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice显示文摘 | Maria Lauda Tomasi Minjung Ryoo Heping Yang Ainhoa Iglesias Ara Kwang Suk Ko Shelly C. Lu | 2014 | Free Radical Biology and Medicine2014，，： | 2 |
| 14 | Chorea-ballism associated with nonketotic hyperglycaemia or diabetic ketoacidosis: Characteristics of 25 patients in Korea显示文摘 | Seung-Hwan Lee Jeong-Ah Shin Ji-Hyun Kim Jang-Won Son Kang-Woo Lee Seung-Hyun Ko Seung-Ho Yang Byung Chul Son Yu-Bae Ahn | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 15 | The Significance of Blood Pressure Variability for the Development of Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Youngchai Ko Jung Hyun Park Mi Hwa Yang Sang-Bae Ko Moon-Ku Han Chang Wan Oh JiSung Lee Juneyoung Lee Hee-Joon Bae | 2010 | Stroke2010，，11： | 2 |
| 16 | Clinical and Histological Features of Nonalcoholic Fatty Liver Disease in Children显示文摘 | Jae Sung Ko Jung Min Yoon Hye Ran Yang Jae Kyung Myung Hye Ryeung Kim Gyeong Hoon Kang Jung-Eun Cheon Jeong Kee Seo | 2009 | Digestive Diseases and Sciences2009，，10： | 2 |
| 17 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 18 | Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins显示文摘 | Dohoon Kim Chun-Hyung Kim Jung-Il Moon Young-Gie Chung Mi-Yoon Chang Baek-Soo Han Sanghyeok Ko Eungi Yang Kwang Yul Cha Robert Lanza Kwang-Soo Kim | 2009 | Cell Stem Cell2009，，6： | 2 |
| 19 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 20 | Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn's disease显示文摘AIM To investigate the clinical implications of infliximab trough levels(IFX-TLs) and antibodies to infliximab(ATI) levels in Crohn's disease(CD) patients in Asian countries. METHODS IFX-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD(quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician's judgment of patients' clinical status at enrollment. The impact of concomitant immunomodulators was also investigated. RESULTS This study enrolled 138 patients with CD(84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively(P < 0.001) and the median ATI levels were 8.064 AU/m L and 11.209 AU/m L, respectively(P < 0.001). In the ATI-negative and-positive groups, the median IFXTLs were 1.415 μg/mL and 0.141 μg/mL, respectively(P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs(0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels(8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083).CONCLUSION IFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice. | Eun Hye Oh Dae-Hyun Ko Hyungil Seo Kiju Chang Gwang-Un Kim Eun Mi Song Myeongsook Seo Ho-Su Lee Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park | 2017 | World Journal of Gastroenterology2017，23，8： | 2 |
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