|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Immunohistological study of intervertebral disc herniation of lumbar spine显示文摘 | Arai Y Yasuma T Shitoto K | 2000 | J Orthop Sci2000，5，3： | 1 |
| 3 | The histology of lunbar intervertebral disc herniation显示文摘 | Yasuma T Arai K Ysmauchi Y | 1993 | Spine1993，18，： | 1 |
| 4 | Unique radiological appearance of a microcystlc meningioma显示文摘 | Shimoji K Yasuma Y Mori K | 1999 | Acta Neurochir (Wien)1999，141，10： | 1 |
| 5 | Generalized Assorted Pixel Camera: Postcapture Control of Resolution, Dynamic Range, and Spectrum 显示文摘 | Fumihito Yasuma Tomoo Misunaga Daisuke Iso | 2010 | IEEE Transactions on Image Processing (S1057-7149)2010，19，9： | 1 |
| 6 | Circadian rhythm of automomic activity in patients with obstructive sleep apnea syndrorme显示文摘 | Noda A Yasuma F Okada T | 2003 | Clin Cardiol2003，21，24： | 1 |
| 7 | Histological development of intervertebral disc herniation显示文摘 | Yasuma T Makino E Saito S | 1986 | J Bone Joint Surg Am1986，68，7： | 1 |
| 8 | Influence of movement arousal on circardian rhythm of blood pressure in obstructive sleep apnea syndrome 显示文摘 | Noda A Yasuma F Okada T | 2000 | J Hypertens2000，18，： | 1 |
| 9 | Immuno histological study of interverte- bral disc hemlation of lumbar spine显示文摘 | Ami Y Yasuma T Shitoto K | 2000 | Jor rthop Sci2000，5，3： | 1 |
| 10 | Upper air- way morphology in patients with obstructive sleep ap- nea syndrome:effects of lateral positioning显示文摘 | SOGA T NAKATA S YASUMA F | 2009 | Auris Nasus Larynx2009，36，： | 1 |
| 11 | Hypothesis, respiratory sinus arrhythmia is an instrinsic resting function of cardiopulmonary system 显示文摘 | Hayano J Yasuma F | 2003 | Car diovasc Res2003，58，1： | 1 |
| 12 | Influence of movement arousal on circadian rhythm of blood pressure in obstructive sleep apnea syndrome显示文摘 | Noda A Yasuma F Okada T | 2000 | Journal of Hypertension2000，18，5： | 1 |
| 13 | The histology of lumbar intervertebral disc herniation: The significance of small blood vessels in the extruded tissue显示文摘 | ARAI K YAMAUCHI Y | 1993 | Spine1993，18，： | 1 |
| 14 | lmmunohistological study of intervertebral disc herniation of lumbar spine显示文摘 | Arai Y Yasuma T Shitoto K | 2000 | J Orthop Sci2000，5，3： | 1 |
| 15 | The histology of lum-bar lntervertebral disc herniation: the significance of small bloodvessels in the extruded tissue显示文摘 | Yasuma T Arai K Yamauchi Y | 1993 | Spine1993，18，13： | 1 |
| 16 | The histology of lumbar intervertebral disc herniation显示文摘 | Arai K Yamauchi | 1993 | Spine1993，18，： | 1 |
| 17 | Influence of movement arousal on circardian rhythm of blood pressure in obstructive sleep apnea syndrome显示文摘 | Noda A Yasuma F Okada T | 2000 | J Hypertens2000，18，： | 1 |
| 18 | Histopathologie study on tumor infiltration into the intervertebral disc显示文摘 | Yasuma T Yamauchi Y Arai K | 1989 | Spine1989，14，11： | 1 |
| 19 | The histology of lumber intervertebral disc herniation显示文摘 | Yasuma T Arai K Yamanochi Y | 1993 | Spine1993，18，： | 1 |
| 20 | Patho genetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome显示文摘 | TAGAYA M NAKATA S YASUMA F | 2010 | Am J Rhinol Allergy2010，24，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员