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| 1 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 2 | Persistence of maternal antibodies against Mycoplasma agassizii in desert tortoise hatchlings显示文摘 | SCHUMACHER I M ROSTAL D C YATES R A | 1999 | Am J Vet Res1999，60，： | 1 |
| 3 | Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial):randomised placebo-controlled trial显示文摘 | ROBERTS I YATES D SANDERCOCK P | 2004 | Lancet2004，364，9442： | 1 |
| 4 | The effect of alkali metals on combustion and pyrolysis of Lolium and Festuca grasses,switchgrass and willow显示文摘 | FAHMI R BRIDGWATER A DARVELL L JONES J YATES N THAIN S DONNISON I | 2007 | Fuel2007，86，10： | 1 |
| 5 | Biological control of Fusarium moniliforme in maize 显示文摘 | Bacon C W Yates I E Hinton D M | 2001 | Environ- mental Health Perspectives2001，109，2： | 1 |
| 6 | Electronic Markets and Electronic Hierarchies 显示文摘 | T Malone J Yates and R I Benjamin | 1987 | Communications of the ACM1987，，6： | 1 |
| 7 | Methylational urinalysis:a prospective study of bladder cancer patients and age stratified benign controls显示文摘 | Yates DR Rehman I Meuth M | 2006 | Oncogene2006，250，13： | 1 |
| 8 | Electronic markets and electronic hierarchies 显示文摘 | Malone T W Yates J Benjamin R I | 1987 | Communications of A CM1987，30，6： | 1 |
| 9 | Electronic markets and electronic hierarchies显示文摘 | Thomas W Malone JoAnne Yates and Robert I Benjamin | 1987 | Communications of the ACM1987，30，6： | 1 |
| 10 | Intrinsic of the Fischer-Tropsch Synthesis on a Cobalt Catalyst显示文摘 | Yates I C Satterfield C N | 1991 | Energy & Fuels1991，5，： | 1 |
| 11 | The logic of electronic markets显示文摘 | Thomas W Malone JoAnne Yates and Robert I Benjamin | 1989 | Harvard Business Review1989，67，56： | 1 |
| 12 | Biological control of Fusarium moniliforme in maize显示文摘 | Bacon C W Yates I E Hinton D M Meredith F | 2001 | Environmental Health Perspectives2001，109，2： | 1 |
| 13 | Electronic markets and electronic hierarchies:effects of information technology on market structure and corporate strategies显示文摘 | MALONE T W YATES J BENJAMIN R I | 1987 | Communication of the ACM1987，30，： | 1 |
| 14 | Biological control of Fusarium moniliforme in maize显示文摘 | Bacon C W Yates I E Hinton D M | | 0，，： | 1 |
| 15 | Promoter hypermethylation identifies progression risk in bladder cancer显示文摘 | Yates DR Rehman I Abbod MF | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 16 | Electronic markets and electronic hierarchies显示文摘 | Malone T W Yates J Benjamin R I | 1987 | Communications of the ACM1987，30，6： | 1 |
| 17 | Effect of intravenouscorticosteroids on death within 14 days in 10008 adults withclinically significant head injury ( MRC CRASH trial ):randomised placebo-controlled trial 显示文摘 | Roberts I Yates D Sandercock P | 2004 | Lancet2004，364，9442： | 1 |
| 18 | Electronic markets and electronic hierarchies,Communication of the ACM显示文摘 | MALONE T W YATES J BENJAMIN R I | 1987 | 30 (June):484 -4971987，，： | 1 |
| 19 | Pecan pollen stored over a decade retains viability显示文摘 | Sparks D Yates I E | 2002 | Hortscience2002，37，1： | 1 |
| 20 | Pecan pollen stored over a decade retains viability显示文摘 | Sparks D Yates I E | 2002 | Hort Science2002，37，1： | 1 |
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