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| 1 | Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction显示文摘证据建议 exosomes 能转移在房间之间的基因材料。然而,他们在肝炎 B 的角色病毒(HBV ) 感染遗体不清楚。这里,我们报导在长期的肝炎 B (CHB ) 病人的 sera 在场的 exosomes 包含了两 HBV nucleic 酸和 HBV 蛋白质,并且以一种活跃方式把 HBV 转移了到 hepatocytes。尤其是, HBV nucleic 酸在生来的杀手(NK ) 被检测从在到 HBV 积极的 exosomes 的暴露以后的 CHB 病人和健康施主的房间。通过即时荧光显微镜学和流动 cytometry, 1,1-dioctadecyl-3,3,3,3, -tetramethylindodicarbocyanine, 4-chlorobenzenesulfnate 盐() 标记的 exosomes 被观察与 NK 房间交往并且被 NK 房间收起,它被转变生长因素提高 -- 治疗。而且, HBV 积极的 exosomes 损害了 NK 房间功能,包括干扰素(IFN )- 生产, cytolytic 活动, NK 房间增长和幸存,以及房间到的应答 poly (我: C ) 刺激。HBV 感染压制了模式识别受体的表示,特别 retinoic 酸可诱导的基因我(RIG-I ) 在 NK 房间上,导致原子因素 B (NF-B ) 和 p38 阻抑激活 mitogen 的蛋白质 kinase 小径。我们的结果在 CHB 感染期间在 HBV 传播和 NK 房间机能障碍加亮 exosomes 的一个以前未得到欣赏的角色。 | Yinli Yang Qiuju Han Zhaohua Hou Cai Zhang Zhigang Tian Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，5： | 47 |
| 2 | Analysis of clinical effect of high-intensity focused ultrasound on liver cancer显示文摘AIM: To evaluate the clinical effect of high-intensity focused ultrasound (HIFU) in the treatment of patients with liver cancer.METHODS: HIFU treatment was performed in 100 patients with liver cancer under general anesthesia and by a targeted ultrasound. Evaluation of efficacy was made on the basis of clinical symptoms, liver function tests, AFP,MRI or CT before and after the treatment.RESULTS: After HIFU treatment, clinical symptoms were relieved in 86.6%(71/82) of patients. The ascites disappeared in 6 patients. ALT (95±44) U/L and AST(114±58) U/L before HIFU treatment were reduced to normal in 83.3%(30/36) and 72.9%(35/48) patients,respectively, after the treatment. AFP was lowered by more than 50% in 65.3%(32/49) patients. After HIFU treatment,MRI or CT findings indicated coagulation necrosis and blood supply reduction or disappearance of tumor in the target region.CONCLUSION: HIFU can efficiently treat the patients with liver cancer. It will offer a significant noninvasive therapy for local treatment of liver tumor. | Chuan-XingLi Guo-LiangXu Zhen-YouJiang Jian-JunLi Guang-YuLuo Hong-BoShan RongZhang YinLi | 2004 | World Journal of Gastroenterology2004，10，15： | 25 |
| 3 | Plant growth and their root development after inoculation of arbuscular mycorrhizal fungi in coal mine subsided areas显示文摘 | Yinli Bi Yanxu Zhang Hui Zou | 2018 | International Journal of Coal Science & Technology2018，5，1： | 17 |
| 4 | Arbuscular mycorrhizal fungi ameliorate the chemical properties and enzyme activities of rhizosphere soil in reclaimed mining subsidence in northwestern China显示文摘In semi-arid region of northwestern China, underground mining subsidence often results in decreased vegetation coverage, impoverishment of soil fertility and water stress. In addition, the physical-chemical and biological properties of soil also change, resulting in more susceptible to degradation. In particular, subsidence causes disturbance of the symbioses of plant and microbe that can play a beneficial role in the establishment of vegetation communities in degraded ecosystems. The objective of this study was to evaluate the effects of revegetation with exotic arbuscular mycorrhizal fungi(AMF) inoculum on the chemical and biological properties of soil over time in mining subsidence areas. Soils were sampled at a depth up to 30 cm in the adjacent rhizosphere of Amorpha fruticose Linn. from five reclaimed vegetation communities in northwestern China. In August 2015, a field trial was set up with five historical revegetation experiments established in 2008(7-year), 2011(4-year), 2012(3-year), 2013(2-year) and 2014(1-year), respectively. Each reclamation experiment included two treatments, i.e., revegetation with exotic AMF inoculum(AMF) and non-AMF inoculum(the control). Root mycorrhizal colonization, glomalin-related soil protein(GRSP), soil organic carbon(SOC), soil nutrients, and enzyme activities were also assessed. The results showed that mycorrhizal colonization of inoculated plants increased by 33.3%–163.0% compared to that of non-inoculated plants(P<0.05). Revegetation with exotic AMF inoculum also significantly improved total GRSR(T-GRSP) and easily extracted GRSP(EE-GRSP) concentrations compared to control, besides the T-GRSP in 1-year experiment and the EE-GRSP in 2-year experiment. A significant increase in SOC content was only observed in 7-year AMF reclaimed soils compared to non-AMF reclaimed soils. Soil total N(TN), Olsen phosphorus(P) and available potassium(K) were significantly higher in inoculated soil after 1–7 years of reclamation(except for individual cases), and increased with reclamation time(besides soil Olsen P). The exotic AMF inoculum markedly increased the average soil invertase, catalase, urease and alkaline phosphatase by 23.8%, 21.3%, 18.8% and 8.6%, respectively(P<0.01), compared with the control. Root mycorrhizal colonization was positively correlated with soil parameters(SOC, TN and soil available K) and soil enzyme activities(soil invertase, catalase, urease and alkaline phosphatase) in both AMF and non-AMF reclaimed soils(P<0.05), excluding availableK in non-AMF reclaimed soils. T-GRSP(P<0.01) and EE-GRSP(P<0.05) were significantly correlated with the majority of edaphic factors, except for soil Olsen P. The positive correlation between root mycorrhizal colonization and available K was observed in AMF reclaimed soils, indicating that the AMF reclaimed soil with a high root mycorrhizal colonization could potentially accumulate available K in soils. Our findings concluded that revegetation with exotic AMF inoculum influenced soil nutrient availability and enzyme activities in the semi-arid ecosystem, suggesting that inoculating AMF can be an effective method to improve soil fertility and support restoration of vegetation communities under poor conditions like soil nutrient deficiency and drought. | QIU Lang BI Yinli JIANG Bin WANG Zhigang ZHANG Yanxu Yryszhan ZHAKYPBEK | 2019 | Journal of Arid Land2019，11，1： | 11 |
| 5 | Dynamic monitoring of soil bulk density and infiltration rate during coal mining in sandy land with different vegetation显示文摘To investigate the effects of coal mining on soil physical properties,sandy lands with three major vegetation types(Salix psammophila,Populus simonii,and Artemisia ordosica)were investigated by the ring knife method and double-ring infiltrometer.Specifically,variations in soil bulk density and water infiltration rate and the influences of coal mining and vegetation type on the properties during different subsidence stages were studied at the Shendong Bulianta mine.The results showed that,in the period before mining,soil bulk density occurred in the order A.ordosica>P.simonii>S.psammophila,with a negative correlation between the initial infiltration rate and steady infiltration rate being observed.In the period during mining and 3 months after mining,there were no significant differences in soil bulk density and water infiltration rate among vegetation types.At 1 year after mining,the soil bulk density occurred in the order A.ordosica>S.psammophila>P.simonii,having a negative correlation with the steady infiltration rate.The water infiltration depths of the S.psammophila,P.simonii and A.ordosica were 50,60,and 30 cm,respectively.The infiltration characters were simulated by the Kostiakov equations,and the simulated and experimental results were consistent.Linear regression revealed that vegetation types and soil bulk density had significant effects on soil initial infiltration rate during the four study periods,and the infiltration rate of the period 1 year after mining was mainly influenced by the soil bulk density of the period before mining.The results indicated that vegetation types had significant effects on soil bulk density,and that the tree-shrub-grass mode was better than one single plantation for water conversation and vegetation recovery in sandy land subjected to mining. | Yinli Bi Hui Zou Chenwei Zhu | 2014 | International Journal of Coal Science & Technology2014，1，2： | 9 |
| 6 | Role of the different planting age of seabuckthorn forests to soil amelioration in coal mining subsidence land显示文摘To investigate the effects of seabuckthorn(Hippophae rhamnoides)on soil amelioration,using the space replacement method,soil physical and chemical indexes as well as the microorganism quantity and soil enzyme activities were analyzed.The results showed that:the soil bulk density of surface soil decreased and soil porosity and field capacity increased after afforestation with seabuckthorn.The plant was found to effectively reduce the soil pH,increase the soil conductivity,soil organic matters and available nutrients.Soil microorganism quantity,soil enzyme activities were both higher in 0-20 cm layer than in 20-40 cm layer.With the increase years of remediation with seabuckthorn,the quantity of soil microorganism and enzyme activities were increasing to a higher level 5 to 8 years later.Our study indicates that seabuckthorn can effectively improve soil physical and chemical properties,increase the quantity of soil microorganisms and enzyme activities,which is of great significance for the ecosystem restoration in mining areas. | Yinli Bi Yanxu Zhang | 2014 | International Journal of Coal Science & Technology2014，1，2： | 6 |
| 7 | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H_2O_2) levels in guard cells in Vicia faba显示文摘The role and signaling of sphingosine-1-phosphate (S1P) during darkness-induced stomatal closure were examined in Vicia faba. Darkness substantially raised S1P and hydrogen peroxide (H 2 O 2 ) levels and closed stomata. These darkness effects were significantly suppressed by DL-threo-dihydrosphingosine (DL-threo-DHS) and N,N-dimethylsphingosine (DMS), two inhibitors of long-chain base kinases. Exogenous S1P led to stomatal closure and H 2 O 2 production, and the effects of S1P were largely prevented by the H 2 O 2 modulators ascorbic acid, catalase, and diphenyleneiodonium. These results indicated that S1P mediated darkness-induced stomatal closure by triggering H 2 O 2 production. In addition, DL-threo-DHS and DMS significantly suppressed both darkness-induced cytosolic alkalization in guard cells and stomatal closure. Exogenous S1P caused cytosolic alkalization and stomatal closure, which could be largely abolished by butyric acid. These results demonstrated that S1P syn-thesis was necessary for cytosolic alkalization during stomatal closure caused by darkness. Furthermore, together with the data described above, inhibition of darkness-induced H 2 O 2 production by butyric acid revealed that S1P synthesis-induced cytosolic alkalization was a prerequisite for H 2 O 2 production during stomatal closure caused by darkness, a conclusion supported by the facts that the pH increase caused by exogenous S1P had a shorter lag and peaked faster than H 2 O 2 levels and that butyric acid prevented exogenous S1P-induced H 2 O 2 production. Altogether, our data suggested that darkness induced S1P synthesis, causing cytosolic alkalization and subsequent H 2 O 2 production, finally leading to stomatal closure. | MA YinLi SHE XiaoPing YANG ShuShen | 2012 | Science China(Life Sciences)2012，55，11： | 4 |
| 8 | Evaluation of COC183B2 antibody targeting ovarian cancer by near-infrared fluorescence imaging显示文摘Objective: To evaluate the imaging potential of a novel near-infrared(NIR) probe conjugated to COC183 B2 monoclonal antibodies(MAb) in ovarian cancer(OC).Methods: The expression of OC183 B2 antigen in OC was determined by immunohistochemical(IHC) staining using tissue microarrays with the H-score system and immunofluorescence(IF) staining of tumor cell lines.Imaging probes with the NIR fluorescent dye cyanine 7(Cy7) conjugated to COC183 B2 Mab were chemically engineered. OC183 B2-positive human OC cells(SKOV3-Luc) were injected subcutaneously into BALB/c nude mice. Bioluminescent imaging(BLI) was performed to detect tumor location and growth. COC183 B2-Cy7 at 1.1,3.3, 10, or 30 μg were used for in vivo fluorescence imaging, and phosphate-buffered saline(PBS), free Cy7 dye and mouse isotype immunoglobulin G(IgG)-Cy7(delivered at the same doses as COC183 B2-Cy7) were used as controls.Results: The expression of OC183 B2 with a high H-score was more prevalent in OC tissue than fallopian tube(FT) tissue. Among 417 OC patients, the expression of OC183 B2 was significantly correlated with the histological subtype, histological grade, residual tumor size, relapse state and survival status. IF staining demonstrated that COC183 B2 specifically expressed in SKOV3 cells but not HeLa cells. In vivo NIR fluorescence imaging indicated that COC183 B2-Cy7 was mainly distributed in the xenograft and liver with optimal tumor-to-background(T/B)ratios in the xenograft at 30 μg dose. The highest fluorescent signals in the tumor were observed at 96 h postinjection(hpi). Ex vivo fluorescence imaging revealed the fluorescent signals mainly from the tumor and liver. IHC analysis confirmed that xenografts were OC183 B2 positive.Conclusions: COC183 B2 is a good candidate for NIR fluorescence imaging and imaging-guided surgery in OC. | Chen Zhang Xinyu Ling Yanxiu Guo Cunzhong Yuan Hongyan Cheng Xue Ye Ruiqiong Ma Yinli Zhang Yi Li Xiaohong Chang Beihua Kong Tao Liu Heng Cui | 2019 | Chinese Journal of Cancer Research2019，31，4： | 4 |
| 9 | Effects of climate change and land-use changes on spatiotemporal distributions of blue water and green water in Ningxia, Northwest China显示文摘Water resources are a crucial factor that determines the health of ecosystems and socio-economic development;however,they are under threat due to climate change and human activities.The quantitative assessment of water resources using the concept of blue water and green water can improve regional water resources management.In this study,spatiotemporal distributions of blue water and green water were simulated and analyzed under scenarios of climate change and land-use changes using the Soil and Water Assessment Tool(SWAT)in Ningxia Hui Autonomous Region,Northwest China,between 2009 and 2014.Green water,a leading component of water resources,accounted for more than 69.00%of the total water resources in Ningxia.Blue water and green water showed a single peak trend on the monthly and annual scales during the study period.On the spatial scale,the southern region of Ningxia showed higher blue water and green water resources than the northern region.The spatiotemporal distribution features of blue water,green water,and green water flow had strong correlations with precipitation.Furthermore,the simulation identified the climate change in Ningxia to be more influential on blue water and green water than land-use changes.This study provides a specific scientific foundation to manage water resources in Ningxia when encountered with climate change together with human activities. | WU Jun DENG Guoning ZHOU Dongmei ZHU Xiaoyan MA Jing CEN Guozhang JIN Yinli ZHANG Jun | 2021 | Journal of Arid Land2021，13，7： | 3 |
| 10 | Recent applications of radical cascade reaction in the synthesis of functionalized 1-indenones显示文摘1-Indenones are important scaffolds in natural products, biologically active molecules as well as functional materials. Recently, radical cascade cyclization has emerged as an efficient and powerful strategy for the construction of valuable and versatile functionalized 1-indenones. In this review, the recent advances of this rapidly growing area were summarized. The selected examples have been classified according to the type of reaction substrates such as 1,3-diarylpropynones, 2-alkynylbenzonitriles, arylpropynols, 1,5-enynes and 2-alkynylated bromocinnamates. | Yinli Zhang Kai Sun Qiyan Lv Xiaolan Chen Lingbo Qua Bing Yu | 2019 | Chinese Chemical Letters2019，30，7： | 2 |
| 11 | Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells显示文摘The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer progression.Guided by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ PAKs.Among these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16.Compound 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,respectively.Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT). | Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao Yuan Su Hanxun Wang Miaomiao Zhou Yujie Wang Yinli Gao Feng Li Dongmei Zhao Fengjiao Zhang Yu Rao Mingyu Xia Haitao Li Jian Wang Maosheng Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 12 | Response of arbuscular mycorrhizal fungi and phosphorus solubilizing bacteria to remediation abandoned solid waste of coal mine显示文摘Coal is the vital resource of energy in China,but abandoned coal ash and gangue lead to the degradation of vegetation cover and reduce soil quality.Both arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing bacteria (PSB) play a key role in biogeochemical cycle such as soil organic matter decomposition,nutrition release,and energy flow.To improve and reclamation the soil quality and ecological efficiency of the coal mining waste,we investigated the effects of an AMF strain (Glomus mosseae) and a PSB strain (Pantoesstewarti) on phytate mineralization and subsequent transfer to the host plant (Medicago sativa L.) using a two-compartment microcosm with a central 30 mm nylon mesh barrier.The results showed that significantly higher available P (AP),above ground biomass (AGB) and underground biomass (UGB) were in combined inoculation of AMF-PSB than other treatments in root and hyphae compartment.The microbial inoculum of the AMF or PSB had a significant influence on soil acid phosphatase activities (ACP).AMF-PSB enhanced phytate mineralization,improved plant biomass.AP and ACP positively influenced the AGB and UGB.AMF-PSB could be used as bioinoculant to enhance sustainable production of the plant in abandoned solid waste of coal mine. | Yinli Bi Li Xiao Rongrong Liu | 2019 | International Journal of Coal Science & Technology2019，6，4： | 2 |
| 13 | Synthesis and characterization of new M-Triazole complexes(M=Co, Cu, Zn) 显示文摘 | ZHANG Yinli CHEN Sanping GAO Shengli | 2009 | J Inorg General Chem2009，635，3： | 1 |
| 14 | Establishment of an artificial diet for successive rearing of Apolygus lucorum (Hemiptera: Miridae) 显示文摘 | Feng Hongqiang Jin Yinli Li Guoping | 2012 | Journal of Economic Entomology2012，105，6： | 1 |
| 15 | Utilization of coal fly ash and municipal sewage sludge in agriculture and for reconstruction of soils in disturbed lands: results of case studies from Greece and China显示文摘 | Christos D. Tsadilas Zhenqi Hu Yinli Bi Thomai Nikoli | 2018 | International Journal of Coal Science & Technology2018，5，1： | 1 |
| 16 | Major and minor structural feature on a bedding shear zone along coal seam and related gas out burst of Pingdingshan coal field 显示文摘 | Huo Yinli | 2001 | International Journal of Coal Geology2001，47，2： | 1 |
| 17 | Effects of limited irrigation on yield and water use efficiency of winter wheat in the Lo- ess Plateau of China显示文摘 | Kang Shaozhong Zhang Lu Liang Yinli | 2002 | Agricultural Water Management2002，55，： | 1 |
| 18 | Hyperspectral diagnosis of nitrogen status in arbuscular mycorrhizal inoculated soybean leaves under three drought conditions显示文摘Precision diagnosis of leaf nitrogen(N)content in arbuscular mycorrhizal inoculated crops under drought stress,using hyperspectral remote sensing technology,would be significant to evaluate the mycorrhizal effect on crop growth condition in the arid and semi-arid region.In this study,soybean plants with inoculation and non-inoculation treatments were grown under severe drought,moderate drought and normal irrigation conditions.Leaf spectral reflectance and several biochemical parameters were measured at 30 d,45 d and 64 d after inoculation.Correlation analyses were conducted between leaf N content and the original and first derivative spectral reflectance.A series of first-order differential area indices and differential area ratio indices were proposed and explored.Results indicated that arbuscular mycorrhizal fungi improved leaf N content under drought stresses,the spectral reflectance in visible to red edge regions of inoculated plants was lower than that of non-inoculated plants.The first-order differential area index at bands of 638-648 nm achieved the best estimation and prediction accuracies in leaf N content inversion,with the determination coefficient of calibration of 0.72,root mean square error of prediction and relative error of prediction of 0.46 and 11.60%,respectively.This study provides a new insight for the evaluation of mycorrhizal effect under drought stress and opens up a new field of application for hyperspectral remote sensing. | Yinli Bi Weiping Kong Wenjiang Huang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 1 |
| 19 | Development of a lateral flow colloidal gold immunoassay strip for the rapid detection of enrofloxacin residues显示文摘 | ZHAO Yinli ZHANG Gaiping LIU Qingtang et ol | 2008 | J Agric Food Chem2008，56，12： | 1 |
| 20 | Effects of limited irrigation on yield and water use efficiency of winter wheat in the Loess Plateau of China显示文摘 | Kang Shaozhong Zhang Lu Liang Yinli | 2002 | Agricultural Water Management2002，55，3： | 1 |
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