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| 1 | Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome显示文摘The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results. | Carlos R Camara-Lemarroy Luanne M Metz V Wee Yong | 2018 | World Journal of Gastroenterology2018，24，37： | 6 |
| 2 | Validation of Aura Microwave Limb Sounder water vapor and ozone profiles over the Tibetan Plateau and its adjacent region during boreal summer显示文摘We present validation studies of MLS V2.2 and V3.3 water vapor(WV) and ozone profiles over the Tibetan Plateau(Naqu and Lhasa) and its adjacent region(Tengchong) respectively by using the balloon-borne Cryogenic Frost point Hygrometer and Electrochemical Concentration Cell ozonesonde. Coincident in situ measurements were selected to compare the MLS V2.2 and V3.3 WV and ozone profiles for understanding the applicability of the two version MLS products over the region. MLS V2.2 and V3.3 WV profiles respectively show their differences within ?2.2±15.7%(n=74) and 0.3±14.9%(n=75) in the stratosphere at and above 82.5 h Pa. Accordingly, at 100 h Pa, the altitude approaching the tropopuase height, differences are within 9.8± 46.0%(n=18) and 23.0±45.8%(n=17), and they are within 21.5±90.6%(n=104) and 6.0±83.4%(n=99) in upper troposphere. The differences of MLS ozone are within ?11.7±16.3%(n=135, V2.2) and 15.6±24.2%(n=305, V3.3) at and above 82.5 h Pa. At 100 h Pa, they are within ?3.5±54.4%(n=27) and ?8.7±41.6%(n=38), and within 18.0±79.1%(n=47) and 34.2±76.6%(n=160) in the upper troposphere. The relative difference of MLS WV and ozone profile has significant oscillation and scatter at upper troposphere and lower stratosphere partly due to the stronger gradients of WV and ozone concentrations here as well the linear interpolation of sonde data for the intercomparison. At and below 70 h Pa, the relative differences of MLS ozone are significantly larger over Lhasa during the Tibetan Plateau 'ozone valley' season, which is also the Asian Summer Monsoon period. The MLS ozone differences over the three sites are similar in their vertical distributions during that period. A simple linear correlation analysis between MLS and sonde profiles indicates that the sensitivity of MLS profile products is related to concentrations at each pressure level. The MLS V3.3 product sensitivity is slightly improved for WV at and above 82.5 h Pa, whereas it is not obvious for ozone. The possible factors contributing to the differences of the MLS profile products of WV and ozone are discussed. | YAN XiaoLu ZHENG XiangDong ZHOU XiuJi Holger VMEL SONG JianYang LI Wei MA YongHong ZHANG Yong | 2015 | Science China Earth Sciences2015，58，4： | 4 |
| 3 | Growth factors for fetal and adult human astrocytes in culture显示文摘 | Yong V W Kim S U Pleasure D E | 1998 | Brain Res1998，444，1： | 2 |
| 4 | Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice 显示文摘 | Xue M Hollenberg M D Yong V W | 2006 | J Neurosci2006，26，10： | 1 |
| 5 | Radiation-induced graft polymerization of glycidyl methacrylate onto nonwoven polypropylene显示文摘 | Bondar Yu V Hong Je Kim Yong Jin Lim | 2005 | Russian Journal of Applied Chemistry2005，78，5： | 1 |
| 6 | Control scheme in hybrid synchronotts- -stationary frame for PWM AC/DC converter under generalized unbalanced operating conditions显示文摘 | Yong S S Tijcras V Lipo T A | 2006 | IEEE Trans on Industial Applications2006，42，3： | 1 |
| 7 | Impact of Clay Microstructure and Mass Absorption Coefficient on the Quantitative Mineral Identification by XRD Analysis显示文摘 | Ouhedi V R Yong R N | 2003 | Applied Clay Science2003，23，： | 1 |
| 8 | 显示文摘 | Yong Z Mata V Rodrigues A E | 2002 | Separation and Purification Technology2002，26，： | 1 |
| 9 | Development of thesmart spring for active vibration control of helicopter blades 显示文摘 | Yong C Zimcik D G Wickramasinghe V K | 2004 | Journal of Intelligent Material Systems and Structures2004，15，1： | 1 |
| 10 | A Comprehensive Study of the Rational Function Model for Photogrammetric Processing显示文摘 | Tao V C Hu Yong | | 0，，12： | 1 |
| 11 | A Comprehensive Study of the Ration- al Function Model for Photogrammetric Processing 显示文摘 | TAO C V HU Yong | 2001 | PE&RS2001，，67： | 1 |
| 12 | A scalable limited feedback design for network MIMO using per-cell product codebook显示文摘 | Cheng Yong Lau V K N | 2010 | Wireless Communications IEEE Transactions on2010，9，10： | 1 |
| 13 | Optical coherence tomography of optic disc swelling in acute primary angle-closure glaucoma显示文摘 | Yip L W Yong V K Hoh S T | 2006 | Acta Ophthalmol2006，123，4： | 1 |
| 14 | Cardiac troponin-T and the pre- diction of acute and long-term mortality 'after acute pulmonary em- bolism显示文摘 | Ng AC Yong AS Chow V | 2011 | International Journal of Cardiology Available online2011，24，： | 1 |
| 15 | Board Monitoring and Earnings Management Do Outside Directors Influence Abnormal Accruals? 显示文摘 | PEASNELL K V P YONG P F S | 2005 | Journal of Business Finance &Accounting2005，32，7： | 1 |
| 16 | Metalloproteinases in biology and pathology of the nervous system显示文摘 | YONG V W POWER C FORSYTH P | 2001 | Nat Rev Neurosci2001，2，： | 1 |
| 17 | Recurrence networks: a novel paradigm for nonlinear time series analysis 显示文摘 | DONNER R V ZOU Yong DONGES J F | 2010 | New Journal of Physics2010，12，03： | 1 |
| 18 | Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm显示文摘 | KATAOKA N YONG J KIM V N | 2000 | Mol Cell2000，6，： | 1 |
| 19 | Diagnostic accuracy and cost-effectiveness of contrast echocardiography on evaluation of cardiac function in technically very difficult patients in the intensive care unit显示文摘 | Yong Y Wu D Fernandes V Kopelen HA | 2002 | American Journal of Cardiology2002，89，6： | 1 |
| 20 | Experimental study on instability of bases on natural and lime/cement-stabilized clayey soils显示文摘 | Yong R N Ouhadi V R | 2007 | Applied Clay Science2007，35，9： | 1 |
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