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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | Antimicrobial activity of Ca (OH)2 containing pastes with Enterococcus faecalis in vitro显示文摘 | Han GY Park SH Yoon TC | 2001 | J Endod2001，27，5： | 1 |
| 3 | Hepatocellular carcino- ma associated with membranous obstruction of the inferi- 3r vena eava: incidence characteristics and risk factors and clinical efficacy of TACE显示文摘 | Gwon D Ko GY Yoon HK | 2010 | Radiology2010，254，2： | 1 |
| 4 | Wnt signaling enhances the activation and survival of human hepatic stellate cells显示文摘 | Myung SJ Yoon JI-I Gwak GY | | 0，，16： | 1 |
| 5 | Hepatocellular carcinoma associated with membranous obstruction of the inferior vena cava: incidence characteristics and risk factors and clinical efficacy of TACE显示文摘 | Gwon D Ko GY Yoon HK | 2010 | Radiology2010，254，2： | 1 |
| 6 | Investigation of hemostatic changes in patients with sepsis显示文摘 | Kim GY Park SY Yoon HJ | | 0，，03： | 1 |
| 7 | Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase ]] ex- pression 显示文摘 | Gwak GY Yoon JH Kim KM | 2005 | J Hepatol2005，42，3： | 1 |
| 8 | Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship显示文摘 | Bang SC Lee JH Song GY Kim DH Yoon MY Ahn BZ | 2005 | Chem Pharm Bull (Tokyo)2005，53，11： | 1 |
| 9 | Endovascular treatment of hepatic venous outflow obstruction after living-donor liver transplantation显示文摘 | Ko GY Sung KB Yoon HK | 2002 | J Vasc Interv Radiol2002，13，： | 1 |
| 10 | Risk factors for post-pneumonectomy acute lung injury/acute respiratory distress syndrome in primary lung cancer patients显示文摘 | Jeon K Yoon JW Suh GY | | 0，，01： | 1 |
| 11 | Endovascular treatment of hepatic venous outflow obstruction after living-donor liver transplantation显示文摘 | Ko GY Sung KB Yoon HK | 2002 | J Vasc Interv Radiol2002，13，： | 1 |
| 12 | Wnt signaling enhances the activation and survival of human hepatic stellate cells显示文摘 | Myung S J Yoon JH Gwak GY | 2007 | FEBS Lett2007，581，16： | 1 |
| 13 | Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase Ⅱ expression 显示文摘 | GWAK GY YOON JH KIM KM | 2005 | J Hepatol2005，42，3： | 1 |
| 14 | Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase Ⅱ expression显示文摘 | Gwak GY Yoon JH Kim KM | 2005 | J Hepatol2005，42，3： | 1 |
| 15 | Risk factors for post-pneumo-nectomy acute lung injury/acute respiratory distress syndrome in primary lung cancer patients 显示文摘 | Jeon K Yoon JW Suh GY | 2009 | Anaesth Intensive Care2009，37，1： | 1 |
| 16 | Percutaneous transhepatic treatment of hepaticojejunal anastomotic biliary strictures after living donor liver transplantation显示文摘 | Ko GY Sung KB Yoon HK | | 0，，： | 1 |
| 17 | Gastric varices and hepat- ic encephalopathy treatment with vascular plug and gelatin sponge -assisted retrograde transvenous obliteration -a prima- ry report显示文摘 | GWON DI KO GY YOON HK | 2013 | Radiology2013，268，1： | 1 |
| 18 | Inferior phrenic artery : anatomy, variations, pathologic conditions, and interventional management 显示文摘 | Gwon DI Ko GY Yoon HK | 2007 | Radiagraphies2007，27，3： | 1 |
| 19 | Investigation of hemostatie changes in patients with sepsis显示文摘 | Kim GY Park SY Yoon HY | 2007 | Korean J Lab Med2007，27，： | 1 |
| 20 | Detection of response - predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas 显示文摘 | Gwak GY Yoon JH Shin CM | 2005 | J Cancer Res Clin Oncol2005，131，10： | 1 |
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