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| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 3 | Proposed failure mechanism in a discontinuously reinforced aluminum alloy 显示文摘 | You C P Thompson A W Bernstein I M | 1987 | Scripta Metall1987，21，： | 1 |
| 4 | Ultrasound pre-treatment step for performance enhancement in an aerobic sludge digestion process显示文摘 | Chang T C You S J Damodar R A | 2011 | Journal of the Taiwan Institute of Chemical Engineers2011，42，5： | 1 |
| 5 | Highly efficient phosphorescent emission from organic electroluminescent devices 显示文摘 | Baldo M A O′Brien D F You Y | 1998 | Nature1998，395，10： | 1 |
| 6 | Highly efficient phosphorescent emission from organic electroluminescence devices显示文摘 | Baldo M A O'Brien D F You Y Shoustikov A Sibley S Thompson M E Forret S R | | 0，，： | 1 |
| 7 | Expression of SFRP Family Proteins in Human Keratoconus Corneas显示文摘 | You J Wen L Roufas A | 2013 | PLoS One2013，8，66： | 1 |
| 8 | Influence of aging on quench sensitivity effect of 7055 aluminum alloy 显示文摘 | LIU S D ZHANG X M CHEN M A YOU J H | 2008 | Materials Characterization2008，59，1： | 1 |
| 9 | Identification of quantitative trait loci across recombinant inbred lines and testcross populations for traits of agronomic im-portance in rice显示文摘 | You A Q Lu X G Jin H J | | 0，，2： | 1 |
| 10 | Thermo-hydraulic characteristics of laminar flow in an enhanced tube with conical strip inserts 显示文摘 | You Y H Fan A W Liu W | 2012 | International Journal of Thermal Sciences2012，61，： | 1 |
| 11 | Impact of viral replication inhibition by entecavir on peripheral T lymphocyte subpopulations in chronic hepatitis B patients 显示文摘 | You J Sriplung H Geater A | 2008 | BMC Infect Dis2008，8，： | 1 |
| 12 | Effect of gas bubbling and impeller agitation on degassing kinetics during magnesium alloy (AZ91D) melt recycling-Water model approach显示文摘 | HAN J W KIM D J YOU B D ENGH T A | 2003 | Materials Science Forum2003，439，： | 1 |
| 13 | The expression of heat shock proteinT0 decreases with cellular senescence /n vitro and in ceils derived from young and old human subjects显示文摘 | Gustmann C A H eydari A R You S | 1998 | Exp Cell Res1998，241，2： | 1 |
| 14 | Highly efficient phosphorescent emission from organic electroluminescent devices 显示文摘 | BALDO M A O'BRIEN D F YOU Y | 1998 | Nature1998，395，： | 1 |
| 15 | Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells显示文摘 | You F Roberts L A Kang S P | 2008 | J Hematol Oncol2008，28，1： | 1 |
| 16 | Calculating stable and unstable manifolds显示文摘 | You Z Kostelich E J Yorke J A | 1991 | Int J Bifurc Chaos Appl Sci Eng1991，1，3： | 1 |
| 17 | 显示文摘 | Shoustikov A A You Y Thompson M | 1998 | IEEE J Selected Topics Quantum Electron1998，4，： | 1 |
| 18 | Three-dimen- sional microstructural modeling of asphalt concrete using a unified viscoelastic-viscoplastic-viscodamage model显示文摘 | You T S A1-Rub R K A Darabi M K | 2012 | Con- struction and Building Materials2012，28，1： | 1 |
| 19 | Experimental and numerical investigations of shell-side thermo-hydraulic performances for shell-and-tube heat exchanger with trefoil-hole baffles显示文摘 | You Y H Fan A W Lai X J | 2013 | Applied Thermal Engineering2013，50，1： | 1 |
| 20 | Polarized erbium-doped superfluorescent fiber source utilizing double-pass backward configuration显示文摘 | Wang L A Lee C T You G W | 2005 | Applied Optics2005，44，1： | 1 |
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