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| 1 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 2 | Two novel gastric cancer-associated genes identified by differential display显示文摘TwonovelgastriccancerassociatedgenesidentifiedbydiferentialdisplayYOUHan,XIAOBing,CUIDaXiang,SHIYongQuanandFANDaiMingSubj... | YOU Han, XIAO Bing, CUI DaXiang, SHI YongQuan and FAN DaiMingKeywords stomach neoplasms gene clone nucleotides sequence analysis in situ hybridization polymerase chain reaction RNA, messenger | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 3 | Comparative study of rendezvous techniques in post-liver transplant biliary stricture显示文摘AIM:To investigate the usefulness of a new rendezvous technique for placing stents using the Kumpe(KMP) catheter in angulated or twisted biliary strictures.METHODS:The rendezvous technique was performed in patients with a biliary stricture after living donor liver transplantation(LDLT) who required the exchange of percutaneous transhepatic biliary drainage catheters for inside stents.The rendezvous technique was performed using a guidewire in 19 patients(guidewire group) and using a KMP catheter in another 19(KMP catheter group).We compared the two groups retrospectively.RESULTS:The baseline characteristics did not differ between the groups.The success rate for placing inside stents was 100% in both groups.A KMP catheter was easier to manipulate than a guidewire.The mean procedure time in the KMP catheter group(1012 s,range:301-2006 s) was shorter than that in the guidewire group(2037 s,range:251-6758 s,P = 0.022).The cumulative probabilities corresponding to the procedure time of the two groups were significantly different(P = 0.008).The factors related to procedure time were the rendezvous technique method,the number of inside stents,the operator,and balloon dilation of the stricture(P < 0.05).In a multivariate analysis,the rendezvous technique method was the only significant factor related to procedure time(P = 0.010).The procedural complications observed included one case of mild acute pancreatitis and one case of acute cholangitis in the guidewire group,and two cases of mild acute pancreatitis in the KMP catheter group.CONCLUSION:The rendezvous technique involving use of the KMP catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stricture that represents a viable alternative to the guidewire rendezvous technique. | Jae Hyuck Chang In Seok Lee Ho Jong Chun Jong Young Choi Seung Kyoo Yoon Dong Goo Kim Young Kyoung You Myung-Gyu Choi Sok Won Han | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 4 | Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells显示文摘Embryonic stem cells(ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers—namely super-enhancers(SEs), on which BRD4, a member of the bromodomain and extraterminal domain(BET) family is highly enriched—could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy. | Jung Hyun Im Seon In Hwang Jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon Hyuk-Jin Cha Hyung-Min Chung Hans R. Scholer Jung Keun Hyun DongWook Han | 2018 | Science Bulletin2018，63，8： | 2 |
| 5 | Prevalence of sleep disorders breathing in middle-aged Korean men and women显示文摘 | KIM J IN K YOU S | 2004 | J Respir Crit Care Med2004，170，： | 1 |
| 6 | D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function显示文摘 | Masato Sasaki Christiane B. Knobbe Momoe Itsumi Andrew J. Elia Isaac S. Harris Iok In Christine Chio Rob A. Cairns Susan McCracken Andrew Wakeham Jillian Haight Annick You Ten Bryan Snow Takeshi Ueda Satoshi Inoue Kazuo Yamamoto Myunggon Ko Anjana Rao Kat | 2012 | Genes & Development2012，，18： | 1 |
| 7 | Synthesis and Structure of 4-Nitrobenzaldehyde Thiosemicarbazone显示文摘SynthesisandStructureof4-NitrobenzaldehydeThiosemicarbazoneTianYu-Peng;DuanChun-Ying;LuZhong-Lin;YouXiao-Zeng(CoordinationChe... | Tian Yu-Peng Duan Chun-Ying Lu Zhong-Lin You Xiao-Zeng(Coordination Chemistry Institute, State Key Laboratory of Coordinatton Chemistry,Nanjing Univuersity, Centre for Advanced Studies in Science and Technology of Microstructure, Hanjing, 210093) Luo B | 1996 | Chinese Journal of Structural Chemistry1996，15，4： | 1 |
| 8 | Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block,and sudden death显示文摘 | Mungrue IN Gros R You X | 2002 | J Clin Invest2002，109，： | 1 |
| 9 | Production of chitooligosaceharides using an ultrafihration membrance reactor and their antibacterial activity显示文摘 | YOU - J IN J SE - KWON K | 2000 | Carbohydrate Polymers2000，，41： | 1 |
| 10 | The impor- tance of organic matter distribution and extract soil:Solution ratio on the desorption of heavy metals from soils显示文摘 | ~IN Y IMPELLITI'ERI C A YOU S J | 2002 | Science of the Total Environment2002，287，12： | 1 |
| 11 | Prevalence of sleep-disordered breathing in middle-aged Korean men and women显示文摘 | In K You S | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 12 | First-order kinetic gas generation model pa- rameters for wet landfills 显示文摘 | AYMAN A FAOUR DEBRA R REINHART HUAX- IN YOU | 2007 | Waste Management2007，27，7： | 1 |
| 13 | Single-port transumbilical laparoscopic appendectomy: 43 consecutive cases显示文摘 | Hyung Jin Kim Jae Im Lee Yoon Suk Lee In Kyu Lee Jung Hyun Park Sang Kuon Lee Won Kyung Kang Hyeon-Min Cho Young Kyuong You Seong Taek Oh | 2010 | Surgical Endoscopy2010，，11： | 1 |
| 14 | Prevalence of sleep-disordered breathing in middle-aged Korean men and women 显示文摘 | Kim J In K You S | 2004 | Am J Respair Crit Care Med2004，170，： | 1 |
| 15 | Leptin’s neuroprotective action in experimental transient ischemic damage of the gerbil hippocampus is linked to altered leptin receptor immunoreactivity显示文摘 | Bing Chun Yan Jung Hoon Choi Ki-Yeon Yoo Choong Hyun Lee In Koo Hwang Sang Guan You Il-Jun Kang Jong-Dai Kim Dae-joong Kim Young-Myeong Kim Moo-Ho Won | 2011 | Journal of the Neurological Sciences2011，，1： | 1 |
| 16 | Paxilline enhances TRAIL-mediated apoptosis of c-FLIP,survivin and DR5显示文摘 | You JK In YK Eun HK | 2011 | Experimental and Molecul-ar Medicine2011，43，1： | 1 |
| 17 | Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects显示文摘 | Young-Mi Jung Seon-Ha Lee Dong-Sub Lee Myung-Jin You In Kwon Chung Woo Hyun Cheon Young-Sam Kwon Young-Joon Lee Sae-Kwang Ku | 2011 | Nutrition Research2011，，5： | 1 |
| 18 | First-order kinetic gas generation model pa- rameters for wet landfills 显示文摘 | AYMAN A FAOUR DEBRA R REINHART HUAX- IN YOU | 2007 | Waste Management2007，27，7： | 1 |
| 19 | Prevalence of sleep-disordered breathing in middle-aged Korean men and women显示文摘 | Kim J In K You S | 2004 | Am J Respair Crit Care Med2004，170，10： | 1 |
| 20 | Single-port transumbilical laparoscopic appendectomy: 43 consecutive cases显示文摘 | Hyung Jin Kim Jae Im Lee Yoon Suk Lee In Kyu Lee Jung Hyun Park Sang Kuon Lee Won Kyung Kang Hyeon-Min Cho Young Kyuong You Seong Taek Oh | 2010 | Surgical Endoscopy2010，，11： | 1 |
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