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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 3 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 4 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘Acute kidney injury(AKI)in cirrhosis,including hepatorenal syndrome(HRS),is a common and serious complication in cirrhotic patients,leading to significant morbidity and mortality.AKI is separated into two categories,non-HRS AKI and HRS-AKI.The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease.The pathophysiology behind non-HRS-AKI and HRS is more complicated than once theorized and involves more processes than just splanchnic vasodilation.The common biomarkers clinicians use to assess kidney injury have significant limitations in cirrhosis patients;novel biomarkers being studied have shown promise but require further studies in clinical settings and animal models.The overall management of non-HRS AKI and HRS-AKI requires a systematic approach.Although pharmacological treatments have shown mortality benefit,the ideal HRS treatment option is liver transplantation with or without simultaneous kidney transplantation.Further research is required to optimize pharmacologic and nonpharmacologic approaches to treatment.This article reviews the current guidelines and recommendations of AKI in cirrhosis. | Kapil Gupta Abhishek Bhurwal Cindy Law Scott Ventre Carlos D Minacapelli Savan Kabaria You Li Christopher Tait Carolyn Catalano Vinod K Rustgi | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 5 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
| 6 | FoxO3a-dependent regulation of puma in response to cytokine/growth factor withdrawal显示文摘 | You H Pellegrini M Tsuchihara K | 2006 | J Exp Med2006，203，7： | 1 |
| 7 | A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells显示文摘 | He B You L Uematsu K | 2004 | Neoplasia2004，6，1： | 1 |
| 8 | Prevalence of sleep disorders breathing in middle-aged Korean men and women显示文摘 | KIM J IN K YOU S | 2004 | J Respir Crit Care Med2004，170，： | 1 |
| 9 | Total knee arthroplasty withoutpatellar resuifacing显示文摘 | Oh I S Kim M K You D S | 2006 | Int Orthop2006，30，5： | 1 |
| 10 | Characteristics of bursal T Lymphocytes induced by Infectious bursal disease virus显示文摘 | Kim I J You S K Kim H | | 0，，： | 1 |
| 11 | KAM-Type Theorem on Resonant Surfaces for Nearly Integrable Hamiltonian Systems显示文摘 | F. Cong T. Küpper Y. Li J. You | 2000 | Journal of Nonlinear Science2000，，1： | 1 |
| 12 | Design and experimental evaluation of synchronous machine without iron loss using double-sided Halbach magnetized PM rotor in high power FESS显示文摘 | Jang S M You D J Ko K J | 2008 | Magnetics IEEE Transactions on2008，44，11： | 1 |
| 13 | Directconverison of cellulose into polyols or H2 over P t/N a (H )-Z S M -5 显示文摘 | YOU S J BEAK I G KIM Y T JEONG K E CHAE H J KIM T W KIM C U KIM T J CHUNG Y M OH S H PARK E D | | Korean J Chem Eng0，28，3： | 1 |
| 14 | COUP-TFII is essential for radial and anteroposterior patterning of the stomach显示文摘 | Takamoto N You L R Moses K | 2005 | Development2005，132，9： | 1 |
| 15 | Analysis of nasal bone fractures;a six-year study of 503 patients显示文摘 | HWANG K YOU S H KIM S | 2006 | J Craniof Surg2006，17，： | 1 |
| 16 | Isocratic elution sys- tem for the determination of catechins, caffeine and gallic acid in green tea using HPLC显示文摘 | WANG Huafu HELLIWELL K YOU Xiaoqing | 2000 | Food Chemistry2000，68，1： | 1 |
| 17 | Finite element failure analysis of reinforced concrete T-girder显示文摘 | Song H W You D W Byun K J | 2002 | Engineering Structures2002，24，2： | 1 |
| 18 | Highly selective co-production of nitroeyclohexane and adipic acid from vapor phase catalytic nitrationxidation of eyclohexane with NOz显示文摘 | You K Y Jian J Xiao H J | 2012 | Catalysis Communications2012，28，： | 1 |
| 19 | Experimental and numerical investigation of convective drying of single coarse lignite particles显示文摘 | Zhang K You C F | 2010 | Energy & Fuels2010，，24： | 1 |
| 20 | Engineering microbial consortia: a new frontier in synthetic biology 显示文摘 | Brenner K You L Arnold FH | 2008 | Trends Biotechnol2008，26，9： | 1 |
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