|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | B lymphocytes on the front line of autoimmunity显示文摘 | Youinou P Hillion S Jamin C | 2006 | Autoimmun Rev2006，5，3： | 1 |
| 3 | Human T cells induce their own regulation through activation of B cells 显示文摘 | Lemoine S Morva A Youinou P | 2011 | J Autoimmun2011，36，34： | 1 |
| 4 | Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32)显示文摘 | Conti P Youinou P Theoharides TC | 2007 | Autoimmune Rev2007，6，3： | 1 |
| 5 | Nanoimprint lithography for the fabrication of DNA electrophoresis chips 显示文摘 | PEPIN A YOUINOU P STUDER V | 2002 | Microelectronic Engineering2002，61，2： | 1 |
| 6 | Concentrations of BAFF correlate with autoantibody levels, clinical dis- case activity, and response to treatment in early rheuma- toid arthritis显示文摘 | Bosello S Youinou P Daridon C | 2008 | J Rheumatol2008，35，7： | 1 |
| 7 | The paradox of CD5^- expressing B cells in systemic lupus erythematosus 显示文摘 | Youinou P Renaudineau Y | 2007 | Autoimmun Rev2007，7，2： | 1 |
| 8 | Regulatory B cells in autoimmune diseases: how do they work? 显示文摘 | Lemoine S Morva A Youinou P | 2009 | Ann NY Acad Sci2009，1173，2： | 1 |
| 9 | Modulation of autoimmunity by the latest interleukins ( with special emphasis on IL-32 ) 显示文摘 | Conti P Youinou P Theoharides T C | 2007 | Autoimmun Rev2007，6，3： | 1 |
| 10 | Viruses contribute to the development of Sjogren's syndrome 显示文摘 | Youinou P Pers JO Saraux A | 2005 | Clin Expimmunol2005，141，7： | 1 |
| 11 | Disturbance of cytokine networks in Sjgren′s syndrome显示文摘 | YOUINOU P PERS J O | 2011 | Arthritis Res Ther2011，13，4： | 1 |
| 12 | B lymphocyte cytokines and rheumatic autoimmune disease 显示文摘 | Youinou P Triller TE Pers JO | 2009 | Arthritis Rheum2009，60，7： | 1 |
| 13 | The weight of interleukin-6 in B cell-relatedautoimmune disorders显示文摘 | Youinou P Jamin C | 2009 | J Autoimmun2009，32，34： | 1 |
| 14 | Regulatory B cells in autoim-mune diseases:how do they work?显示文摘 | Lemoine S Morva A Youinou P | 2009 | Ann N Y Acad Sci2009，1173，： | 1 |
| 15 | Modulation of autoim munity by the latest interleukins (with special emphasis on IL-32)显示文摘 | Conti P Youinou P Theoharides TC | 2007 | Autoimmun Rev2007，6，3： | 1 |
| 16 | B lymphocytes on the front line of autoimmunity 显示文摘 | Youinou P Hillion S Jamin C | 2006 | Autoimmun Rev2006，5，3： | 1 |
| 17 | Viruses contribute to the development of Sjogren's syndrome显示文摘 | Youinou P Pets JO Saraux A | 2005 | Clin Exp Immunol2005，141，1： | 1 |
| 18 | Latest update on the primary Sj6gren's syndrome显示文摘 | Youinou P Pers JO | 2012 | Presse Med2012，41，92： | 1 |
| 19 | Regulatory B cells in autoim- mune diseases: how do they work 显示文摘 | Lemoine S Morva A Youinou P | 2009 | Ann N Y Aead Sci2009，，1173： | 1 |
| 20 | At the crossroads between B lymphoproliferative syndromes to autoimmunediseases are CD5 positive B lymphocytes: a new hypothesis显示文摘 | Youinou P | 1999 | Bull Acad NatlMed1999，183，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员