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| 1 | Circulating microRNAs in patients with non-alcoholic fatty liver disease显示文摘AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. | Serkan Dogan Gokmen Zararsiz Sebnem Gursoy Kadri Guven Omer Ozbakir Munis Dundar Mehmet Yucesoy | 2014 | World Journal of Hepatology2014，6，8： | 13 |
| 2 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 3 | Epinephrine plus argon plasma or heater probe coagulation in ulcer bleeding显示文摘AIM:To compare the effectiveness of argon plasma coagulation (APC) and heater probe coagulation (HPC) in non-variceal upper gastrointestinal bleeding.METHODS:Eighty-five (18 female,67 male) patients admitted for acute gastrointestinal bleeding due to gastric or duodenal ulcer were included in the study.Upper endoscopy was performed and HPC or APC were chosen randomly to stop the bleeding.Initial hemostasis and rebleeding rates were primary and secondary end-points of the study.RESULTS:Initial hemostasis was achieved in 97.7% (42/43) and 81% (36/42) of the APC and HPC groups,respectively (P < 0.05).Rebleeding rates were 2.4% (1/42) and 8.3% (3/36) in the APC and HPC groups,respectively,at 4 wk (P > 0.05).CONCLUSION:APC is an effective hemostatic method in bleeding peptic ulcers.Larger multicenter trials are necessary to confirm these results. | Ahmet Karaman Mevlut Baskol Sebnem Gursoy Edip Torun Alper Yurci Banu Demet Ozel Kadri Guven Omer Ozbakir Mehmet Yucesoy | 2011 | World Journal of Gastroenterology2011，17，36： | 4 |
| 4 | Thyroid function tests in non-alcoholic cirrhotic patients with hepatic encephalopathy 显示文摘 | Guven K Keletimur F Yucesoy M | 1993 | Eur J Med1993，2，： | 1 |
| 5 | Performance of Chromagar candida and BIGGY agar for identification of yeast species显示文摘 | Yucesoy M Marol S | 2003 | Ann Clin Microbiol Antimicrob2003，292，1： | 1 |
| 6 | The effect of bee propolis on oral pathogens and human gingival fibroblasts 显示文摘 | Sonmez S Kirilmaz L Yucesoy M | 2005 | Journal of Ethnopharmacology2005，102，3： | 1 |
| 7 | Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers显示文摘 | Ates I Suzen HS Yucesoy B | 2008 | American Journal Of Industrial Medicine2008，51，10： | 1 |
| 8 | Increase in spinal canal area after inverse lamino plasty:ananatomical study显示文摘 | Yucesoy K Crawford NR | 2000 | Spine2000，25，： | 1 |
| 9 | IL-1beta gene polymorphisms influence hepatitis B vaccination显示文摘 | Yucesoy B Sleijffers A Kashon M | 2002 | Vaccine2002，20，2526： | 1 |
| 10 | Doppler sonogruphy in renal artery stenesis an evaluation of intrarenal and extrsrenal imaging parameters显示文摘 | Conkbayir I Yucesoy C Edyner T | 2003 | Clin Imaging2003，27，4： | 1 |
| 11 | Genetic susceptibility to progressive massive fibrosis in coal miners 显示文摘 | YUCESOY B JOHNSON V J KISSLING G E | 2008 | Eur Respir J2008，31，6： | 1 |
| 12 | Acute fatty liver of pregnancy complicated with disseminated intravascular coagulation and haemorrhage: a case report显示文摘 | Yucesoy G Ozkan SO Bodur H | 2005 | Int J Clin Pract Suppl2005，147，： | 1 |
| 13 | Conventional galactography and MR contrast galact-ography for diagnosing nipple dis- charge:preliminary results显示文摘 | Yucesoy C Ozturk E Ozer Y | 2008 | Korean Radiol2008，9，5： | 1 |
| 14 | Application of mid-infrared spectroscopy for the measurement of several quality parameters of alcoholic beverages, wine and raki 显示文摘 | OZTURK B YUCESOY D OZEN B | 2012 | Food Anal Methods2012，，5： | 1 |
| 15 | Influence of cytokine gene variations on immunization to childhood vaccine显示文摘 | Yucesoy B Johnson V J Fluharty K | 2009 | Vaccine2009，27，50： | 1 |
| 16 | Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis 显示文摘 | YUCESOY B VALLYATHAN V LANDSITTEL D P | 2001 | Toxicol Appl Pharmacol2001，172，1： | 1 |
| 17 | Prevalence, susceptibility profile and proteinase production of yeasts causing vulvovaginitis in Turkish women 显示文摘 | Ozcan SK Budak F Yucesoy G | 2006 | APMIS2006，114，2： | 1 |
| 18 | Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis显示文摘 | Yucesoy B Vallyathan V Landsittel DP | 2001 | Toxicol Appl Pharmacol2001，172，： | 1 |
| 19 | Effects of occupational lead and cadmium expose on some immunoregulatory cytokine in man显示文摘 | Yucesoy B Turhan A Ure M | 1997 | Toxicology1997，123，： | 1 |
| 20 | Lumbar intraradicular disc hemiatian:report of a rare and preoperatively unpredictable case and review of the literature显示文摘 | Yurtsever C Yucesoy K | 2006 | The Spine Journal2006，5，5： | 1 |
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