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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 4 | Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study显示文摘BACKGROUND:Fatty liver is a common chronic liver disease worldwide.It is associated with an increasing morbidity in China in recent years.The aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty liver.METHODS:We investigated the clinical and laboratory data of 669 patients with fatty liver.Of the 669 patients,166 consumed alcohol more than 60 g per week for at least 2 years,and 503 did not have a history of long-term alcohol consumption.We further analyzed the relationship between alcohol consumption and clinical characteristics of these patients.RESULTS:The values of aspartate transaminase (AST),gammaglutamyl transpeptidase (GGT),and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P<0.05).In the patients without long-term alcohol consumption,the values of GGT and hemoglobin in patients with light alcohol consumption were significantly higher than those in non alcohol consumers (P<0.05).CONCLUSION:Alcohol consumption is associated with significantly increased values of AST,GGT,and hemoglobin in patients with fatty liver,suggesting their potential roles in hepatic steatosis. | International Health Care Center (Wang XF) and Department of Gastroenterology (Yue M),First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 5 |
| 5 | Competition between collective oblate rotation and non-collective prolate K isomerism in neutron-rich tungsten isotopes显示文摘Recent experiments open up the possibility to investigate oblate rotation-aligned states and prolate high-K isomers in neutron-rich tungsten isotopes.In the present work,we perform the projected-shell-model calculations for A ~ 190 tungsten nuclei.The 190 W results are compared with experimental data.The observed 8 + isomer is assigned as a two-quasiproton K π = 8 + configuration.Low-lying high-K four-quasiparticle states are predicted.Of particular interest is the prediction of the K π = 20 + state in 190,192 W,which may form a long-lived spin trap.In competition with the prolate high-K states,rotational alignment leads to near-yrast collective oblate rotation. | JIAO ChangFeng SHI Yue XU FuRong SUN Yang WALKER P M | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 5 |
| 6 | Microstructure and Wear Behaviour of Laser-Induced Thermite Reaction Al_2O_3 Ceramic Coatings on Pure Aluminum and AA7075 Aluminum Alloy显示文摘Wear-resistant laser-induced thermite reaction Al_2O_3 ceramic coatings can be fabricated on pure Al and AA7075 aluminum alloy by laser cladding(one-step method)and laser cladding followed by laser re-melting(two-step method)using mixed powders CuO-Al-SiO_2 in order to improve the wear properties of aluminum and aluminum alloy,respectively.The microstructure of the coatings was characterized by scanning electron microscopy(SEM)and X-ray diffraction(XRD).The wear resistance of the coatings was evaluated under dry sliding wear test condition at room temperature.Owing to the presence of hardα-Al_2O_3 andγ-Al_2O_3 phases,the coatings exhibited excellent wear resistance.In addition,the wear resistance of the coatings fabricated by two-step method is superior to that of the coatings fabricated by one-step method. | 黄开金 LIN Xin XIE Changsheng T M Yue | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，1： | 4 |
| 7 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 8 | Tracking visible boundary of objects using occlusion adaptive motion snake显示文摘 | FU Yue ERDEM A T TEKALP A M | 2000 | IEEE Transactions on Image Processing2000，9，12： | 1 |
| 9 | DNA translocation in inorganic nanotubes 显示文摘 | FAN R KARNIK R YUE M | 2005 | Nano Lett2005，5，： | 1 |
| 10 | Histone H2A has a novelvariant in fish oocytes 显示文摘 | Wu N Yue H M Chen B | 2009 | Biology of Reproduction2009，81，： | 1 |
| 11 | Identification of novel tumor markers in hepatitis C virus associated hepatocellular carcinoma显示文摘 | SMITH M W YUE Z N GEISS G K | | Cancer Res0，63，4： | 1 |
| 12 | Promoting Effect of Al on SO42-/MxOy(M=Zr,Ti,Fe) Catalysts显示文摘 | Hua W M Xia Y D Yue Y H | 2000 | Journal of Catalysis2000，196，1： | 1 |
| 13 | Biologically active phenols from Saussurea medusa显示文摘 | FAN C Q YUE J M | 2003 | Bioorg Med Chem2003，11，5： | 1 |
| 14 | Gel network structure of methylcellulose in water 显示文摘 | Li L Thangamathesvaran P M Yue C Y | 2001 | Langmuir2001，17，26： | 1 |
| 15 | The effect of excimer laser surface treatment on the pitting corrosion fatigue behaviour of alnminium alloy 7075 显示文摘 | Chan C P Yue T M Man H C | 2003 | Journal of Materials Science2003，15，12： | 1 |
| 16 | The developmental biology of feather follicles显示文摘 | Yu M Yue Z Wu P | 2004 | Int J Dev Boil2004，48，23： | 1 |
| 17 | Joint features and mechanical properties of friction stir lap welding assisted by external stationary shoulder显示文摘 | Li Z W Yue Y M Ji S D | 2016 | Materials and Design2016，90，15： | 1 |
| 18 | Efficient CO2 capturer derived from as-synthesized MCM-41 modified with amine显示文摘 | Yue M B Sun L B Cao Y | 2008 | Chem Eur J2008，14，11： | 1 |
| 19 | Refinement of actions for real-time concurrent systems with causal ambiguity 显示文摘 | Majster-Cederbaum M Wu J Yue H | 2006 | Acta Informatica2006，42，67： | 1 |
| 20 | Influence of He-Ne Laser Pretreatment on thermodynamic parameters and growth of Isatis indigotica 显示文摘 | Chen YP Yue M Wang XL | 2005 | Plant SC2005，168，： | 1 |
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