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| 1 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 2 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 3 | Spontaneous complete regression of hepatic epithelioid haemangioendothelioma显示文摘 | Zaher K Otrock Aghiad Al-Kutoubi Mireille M Kattar Ghazi Zaatari Assaad Soweid | 2006 | Lancet Oncology2006，，5： | 2 |
| 4 | Re-operation for the Treatment of well Differentiated Thyroid Cancer:Necessity,Safety and Impaction on Further Management显示文摘 | El-Zohairy M Zaher A | 2004 | J Egypt Natl Canc Inst2004，16，3： | 1 |
| 5 | Effect of pulsed dye laser on intercellular adhesion molecule-1 ( ICAM-1 ) expression after treatment of psoriasis显示文摘 | Solimana M Zaher H EI Danasouri N | 2011 | Med- ical Laser Application2011，26，1： | 1 |
| 6 | Usefulness of neutrophil to lymphocyte ratioin predicting short- and long-term mortality after non-ST-elevation myocardialinfarclion显示文摘 | Azab B Zaher M Weiserbs KF | 2010 | Am J Cardiol2010，106，4： | 1 |
| 7 | Enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by Ti (IV) complexes of Cz-symmetrical chiral BINOL derivatives 显示文摘 | Gou S H Zaher M A Judeh | 2008 | Tetrahedron Letters2008，50，： | 1 |
| 8 | Comparative studies on alkylation of phenol with tertbutyl alcohol in the presence of liquid or solid catalysts in ionil liquids显示文摘 | SHEN Hao - yu Zaher M A CHI Bun - ching XIA Qing - hua | 2004 | Journal of molecular catalysis A: chemcal2004，212，： | 1 |
| 9 | Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after aon-ST-elevation myocardial infarction 显示文摘 | Azab B Zaher M Weiserbs KF | 2010 | Am J Cardiol2010，106，4： | 1 |
| 10 | Human stromal (mesenchymal) stem cells: basic biology and current clinical use for tissue regeneration 显示文摘 | Aldahmash A Zaher W A1-Nbaheen M | 2012 | Ann Saudi Med2012，32，： | 1 |
| 11 | Lupus miliaris disseminatus faciei-pathologic study of early, fully developed, and late lesions显示文摘 | Darouti M Zaher H | 1993 | Int J Dermatol1993，32，7： | 1 |
| 12 | Lupus miliaris disseminatus faciei-pathologic study of early,fullydeveloped,and late lesions显示文摘 | El Darouti M Zaher H | 1993 | Int J Dermatol1993，32，7： | 1 |
| 13 | Relation between anemia and blood levels of lead, copper, zinc and ironamong children 显示文摘 | Hegazy A A Zaher M M El-hafez M A A | 2010 | BMC Research Note2010，3，1： | 1 |
| 14 | Nonlinear control of permanent magnet stepper motors显示文摘 | Harb Ahmad M Zaher Ashraf A | 2004 | Communications in Nonlinear Science and Numerical Simulation2004，，1： | 1 |
| 15 | Usefulness of neutrophil to lymphocyte ratio in predicting short-and long-term mortality after non-ST-elevation myocardial infarction 显示文摘 | Azab B Zaher M Weiserhs KF | 2010 | Am J Cardiol2010，106，： | 1 |
| 16 | Low-dose broad-band UVAin morphea using a new method for evaluation 显示文摘 | El-Mofty M Zaher H Bosseila M | 2000 | PhotodermatolPhotoimmunol Photomed2000，16，： | 1 |
| 17 | Rubberized portland cement concrete显示文摘 | KHATIH and FOUAD M BAYOMY | 1999 | Journal of Materials in Civil Engineering1999，11，3： | 1 |
| 18 | Rubberized portland cement concrete显示文摘 | Khatib Zaher K Bayomy Fouad M | 1999 | Journal of Materials in Civil Engineering1999，，8： | 1 |
| 19 | Rubberized portland cement concrete显示文摘 | Khatib Zaher K Bayomy Fouad M | 1999 | Journal of Materials in Civil Engineering1999，11，3： | 1 |
| 20 | Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide显示文摘 | Manal E A Elhalwagy Darwish N S Zaher E M | 2008 | Pesticide Biochemistry and Physiology2008，91，2： | 1 |
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