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| 1 | Role of surgery in colorectal cancer liver metastases显示文摘Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their disease.Surgical resection represents the only chance of long-term survival.The goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic parenchyma.Although resection remains the only chance of long-term survival,management strategies should be tailored for each case.For patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and cure.The use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical treatment.Despite current treatment options,many patients still experience a recurrence after hepatic resection.More active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after surgery.Local tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor lesions.Formulation of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary team.The aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis. | ?zgür Akgül Erdin? ?etinkaya ?iyar Ers?z Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，20： | 40 |
| 2 | Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department显示文摘BACKGROUND: Harmless acute pancreatitis score(HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width(RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department(ED).METHODS: Patients diagnosed with acute pancreatitis(K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography(CT) in the ED were not included in the study.RESULTS: Ultimately, 322 patients were included in the study. The median age of the patients was 53.1(IQR=36–64). Of the patients, 68.1%(n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3%(n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification(OR: 15; 95% CI: 3.5 to 64.4).CONCLUSIONS: HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classifi cation. | Bedia Gülen Ertan Sonmez Serpil Yaylaci Mustafa Serinken Cenker Eken Ali Dur Figen Tunali Turkdogan ?zgür S?güt | 2015 | World Journal of Emergency Medicine2015，6，1： | 13 |
| 3 | Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection显示文摘AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer. | özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 11 |
| 4 | Tribological Properties of CrN Coated H13 Grade Tool Steel显示文摘The characteristics of CrN coated martensitic H13 grade tool steels were studied.CrN coatings were deposited by the arc physical vapor deposition(PVD)before and after the pulse plasma nitriding of the samples.The PVD and plasma nitriding techniques were applied in relevant workshops by following the commercial practice parameters.Experimental results showed that CrN coating deposited on the nitrided surfaces exhibited superior scratch and wear resistances as compared to that deposited on the original martensitic surface. | Erdem Atar zgür Alpaslan zgür elik Hüseyin imenoglu | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 5 |
| 5 | Effect of sodium tungstate on visual evoked potentials in diabetic rats显示文摘AIM: To evaluate the effect of sodium tungstate on visual evoked potentials(VEPs) in diabetic rats.· METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin(50 mg/kg). Sodium tungstate [40 mg/(kg·d)]was administered for 12 wk and then VEPs were recorded.Additionally, thiobarbituric acid reactive substance(TBARS) levels were measured in brain tissues.·RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.· CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use. | Mehmet Bulut Bariszgür Dnmez Nihai ztürk Gksum Basaranlar Ceren Kencebay Manas Narin Derin Semir zdemir | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 6 | Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis显示文摘 | Hassan R Laszik ZG Lemer M | 2005 | Am J Clin Pathol2005，124，6： | 1 |
| 7 | Protective effect of ulinastatin aganist ischemia- reperfusion injury in rat small howel transplantation 显示文摘 | Zhang XQ Mei R Yuan ZG | 2004 | Transplant Proc2004，36，5： | 1 |
| 8 | The impact of hyperthermic chemotherapy on human gastric cancer cell lines:preliminary results显示文摘 | TANG R ZHU ZG QU Y | 2006 | Oncol Rep2006，16，3： | 1 |
| 9 | On pseudoparallel invariant submanifolds of contact metric manifolds显示文摘 | Sular S Cihanzgür C Murathan C | 2007 | Bull Transilv Univ Brasov Ser B(N S)2007，14，49： | 1 |
| 10 | Ganglioneuroma mimicking ovarian tumor: a report of a case and review of the ganglioneuromas显示文摘 | Murat Gültekin Polat Dursun Coskun Salman ?zgür ?zyüncü Arzu Saglam Türkan Kü?ükali Ali Ayhan | 2005 | Archives of Gynecology and Obstetrics2005，，1： | 1 |
| 11 | Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity显示文摘 | ?zgür Devrim Can ümide Demir ?zkay | 2012 | Phytother Res2012，，11： | 1 |
| 12 | Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML RARα independent manner显示文摘 | Wang ZG Rivi R Delva L | 1998 | Blood1998，92，： | 1 |
| 13 | Pseudoparallel anti-invariant submanifolds of Kenmotsu manifolds显示文摘 | Sular S Cihanzgür C Murathan C | 2010 | Hacettepe Journal of Mathematics and Statistics2010，39，4： | 1 |
| 14 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 15 | Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L):final results显示文摘 | Thomas MH Rema R Kama ZG | 2010 | Stroke2010，41，10： | 1 |
| 16 | Intrapleural hyperthermic perfusion chemotherapy in subjects with metastatic pleural malignancies显示文摘 | Ahmet Feridun I??k Maruf ?anl? Miray Y?lmaz Fatih Metero?lu ?ner Dikensoy Alper Sevin? Celaletdin Camc? Bülent Tun??zgür Levent Elbeyli | 2013 | Respiratory Medicine2013，，： | 1 |
| 17 | Forecasting volatility in oil prices with a class of nonlinear volatility models:smooth transition RBF and MLP neural networks augmented GARCH approach显示文摘In this study, the forecasting capabilities of a new class of nonlinear econometric models, namely, the LSTAR-LST-GARCH-RBF and MLP models are evaluated. The models are utilized to model and to forecast the daily returns of crude oil prices. Many financial time series are subjected to leptokurtic distribution, heavy tails, and nonlinear conditional volatility. This characteristic feature leads to deterioration in the forecast capabilities of traditional models such as the ARCH and GARCH models.According to the empirical findings, the oil prices and their daily returns could be classified as possessing nonlinearity in the conditional mean and conditional variance processes.Several model groups are evaluated:(i) the models proposed in the first group are the LSTAR-LST-GARCH models that are augmented with fractional integration and asymmetric power terms(FIGARCH, APGARCH, and FIAPGARCH);(ii) the models proposed in the second group are the LSTAR-LST-GARCH models further augmented with MLP and RBF type neural networks. The models are compared in terms of MSE, RMSE, and MAE criteria for in-sample and out-of-sample forecast capabilities. The results show that the LSTAR based and neural network augmented models provide important gains over the single-regime baseline GARCH models, followed by the LSTAR-LST-GARCH type models in terms of modeling and forecasting volatility in crude oil prices. | Melike Bildirici zgÖrü Ersin | 2015 | Petroleum Science2015，12，3： | 1 |
| 18 | Effect of diesel–microalgae biodiesel–butanol blends on performance and emissions of diesel engine显示文摘 | G?khan Tüccar Tayfun ?zgür Kadir Ayd?n | 2014 | Fuel2014，，： | 1 |
| 19 | Impaired natural killer (NK) cell activity in leptin receptor deficient mice:leptin as a critical regulator in NK cell development and activation 显示文摘 | Tian ZG Sun R Wei HM | 2002 | Biochem Biophys Res Commun2002，298，3： | 1 |
| 20 | Visual Acuity Comparison of Vitrectomy with and without Internal Limiting Membrane Removal in the Treatment of Diabetic Macular Edema显示文摘 | Mehmet Bahad?r Aylin Ertan ?zgür Merto?lu | 2005 | International Ophthalmology (-)2005，，1： | 1 |
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